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| 1 | Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany显示文摘AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET warrant our attention as well as intensive research on their tumorigenesis. | Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe | 2013 | World Journal of Gastroenterology2013，19，47： | 16 |
| 2 | Adult-to-adult right lobe living donor liver transplantation:Comparison of endoscopic retrograde cholangiography with standard T2-weighted magnetic resonance cholangiography for evaluation of donor biliary anatomy显示文摘AIM: To compare the value of endoscopic retrograde cholangiography (ERC) and standard T2-weighted magnetic resonance cholangiography (MRC) in the evaluation process as adult-to-adult right lobe living donor liver transplantation (LDLTx) demands a successful outcome, and exact knowledge of the biliary tree is implicated to avoid biliary complications, postoperatively.METHODS: After starting the LDLTx program, 18 liver transplant candidates were selected for LDLTx by a stepwise evaluation process. ERC and standard T2-weighted MRC were performed to evaluate the biliary system of the donor liver. The anatomical findings of ERC and MRC mapping were compared using the Ohkubo classification. RESULTS: ERC allowed mapping of the whole biliary system in 15/15 (100%) cases, including 14/15 (93.3%) with biliary variants while routine MRC was only accurate in 2/13 (15.4%) cases. MRC was limited in depicting the biliary system proximal of the hepatic bifurcation. Postoperative biliary complications occurred in 2 donors and 8 recipients. Biliary complications were associated with Ohkubo type C, E or G in 6/8 recipients, and 2/3 recipients with biliary leak received a graft with multiple (≥2) bile ducts. CONCLUSION: Pretransplant ERC is safe and superior over standard MRC for detection of biliary variations that occur with a high frequency. However, precise knowledge of biliary variants did not reduce the incidence of postoperative biliary complications. | Perdita Wietzke-Braun Felix Braun Dieter Müller Thomas Lorf Burckhardt Ringe Giuliano Ramadori | 2006 | World Journal of Gastroenterology2006，12，36： | 5 |
| 3 | p16^INK4A as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep smears显示文摘 | Murphy N Ring M Killalea AG | 2003 | J Clin Pathol2003，56，1： | 1 |
| 4 | Further characterization of the expression in liver and catalytic activity of CYP 26B显示文摘 | Ekins S VandenBranden M Ring BJ | 1998 | J Pharmacol Exp Ther1998，266，： | 1 |
| 5 | Novel efficient DOPObased flame-retardants for PWB relevant epoxy resins with high glass transition temperatures显示文摘 | Ciesielski M Sch(a)er A D(o)ring M | 2008 | Polym Advan Techn2008，19，6： | 1 |
| 6 | Interleukin-6 and tumour necrosis factor-αdifferentially regulate linc RNA transcripts in cells of the innate immune system in vivo in human subjects with rheumatoid arthritis显示文摘 | Müller N D觟ring F Klapper M | 2014 | Cytokine2014，68，1： | 1 |
| 7 | Hepatoeyte-nuclear-factor-lalpha(HNF-lalpha), GATA-4 and caudal-related homeodomain protein Cdx2 functionally interact to modulate intestinal gene transcription:Implication for the developmental regulation of the sucrase-isomaltase gene 显示文摘 | Boudreau F Rings E H Wering H M V | 2002 | Journal of Biological Chemistry2002，，31： | 1 |
| 8 | The human drug metabolizing cytochromes P450显示文摘 | Wrighton SA VandenBranden M Ring BJ | 1996 | J Pharmacokinet Biopharm1996，24，5： | 1 |
| 9 | Fractures of the radialhead 显示文摘 | Duckworth A D McQueen M M Ring D | 2013 | Bone Joint J2013，95，2： | 1 |
| 10 | Complete nueleotide sequence of the bovine beta - casein gene 显示文摘 | Bonsing J Ring J M Stewart A F | 1988 | Australian Journal of Biological Sciences1988，41，4： | 1 |
| 11 | Expression of tissue inhibitor of metalloproteinases TIMP-2 in human colorectal a predictor of tumour stage 显示文摘 | Ring P Johansson K Hoyhtya M | 1997 | Br J Cancer1997，76，6： | 1 |
| 12 | p16INK4A as a maker for cervical dyskaryosis:CIN and Cgin cervical biopsies and Thinprep smears显示文摘 | Murphy N Ring M Killalea AG | 2003 | J clin Pathol2003，56，1： | 1 |
| 13 | celalim of amylose显示文摘 | Miles M J Morri V J Ring S G | 1985 | Carbohydrate Research1985，135，2： | 1 |
| 14 | p16INK4A as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep smears显示文摘 | Murphy N Ring M Killalea AG | 2003 | Jclin Pathol2003，56，1： | 1 |
| 15 | Cardiac function in mild primary hyperparathyroidism and the outcome after parathyroidectomy显示文摘 | Farahnak P Ring M Caidahl K | | 0，，03： | 1 |
| 16 | p16IK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer显示文摘 | Murphy N Ring M Heffron CC | 2005 | Jclin Pathol2005，58，5： | 1 |
| 17 | Targeting of autoantigens to DEC205 +dendritic cells in vivo suppresses experimental allergic encephalomyelitis in mice 显示文摘 | Ring S Maas M Nettelbeck D M | 2013 | J Immunol2013，191，6： | 1 |
| 18 | Elbow dislocation with intra-articular fracture: the results of operative treatment without repair of the medial collateralligament显示文摘 | Forthman C Henket M Ring DC | 2007 | J Hand Surg Am2007，32，： | 1 |
| 19 | p16INK4A as a marker for cervical dyskaryosis:CIN and cGIN in cervical biopsies and ThinPrep smears显示文摘 | Murphy N Ring M Killalea AG | 2003 | J Clin Pathol2003，56，1： | 1 |
| 20 | Evaluation of liquid-based cytology in cervical screening of high-risk populations:a split study of colposcopy and genito-urinary medicine populations显示文摘 | Ring M Bolger N O'Donnell M | 2002 | Cytopathology2002，13，3： | 1 |
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