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| 1 | Melanoma:Molecular genetics,metastasis,targeted therapies,immunotherapies,and therapeutic resistance显示文摘Cutaneous melanoma is a common cancer and cases have steadily increased since the mid 70s.For some patients,early diagnosis and surgical removal of melanomas is lifesaving,while other patients typically turn to molecular targeted therapies and immunotherapies as treatment options.Easy sampling of melanomas allows the scientific community to identify the most prevalent mutations that initiate melanoma such as the BRAF,NRAS,and TERT genes,some of which can be therapeutically targeted.Though initially effective,many tumors acquire resistance to the targeted therapies demonstrating the need to investigate compensatory pathways.Immunotherapies represent an alternative to molecular targeted therapies.However,inter-tumoral immune cell populations dictate initial therapeutic response and even tumors that responded to treatment develop resistance in the long term.As the protocol for combination therapies develop,so will our scientific understanding of the many pathways at play in the progression of melanoma.The future direction of the field may be to find a molecule that connects all of the pathways.Meanwhile,noncoding RNAs have been shown to play important roles in melanoma development and progression.Studying noncoding RNAs may help us to understand how resistance e both primary and acquired e develops;ultimately allow us to harness the true potential of current therapies.This review will cover the basic structure of the skin,the mutations and pathways responsible for transforming melanocytes into melanomas,the process by which melanomas metastasize,targeted therapeutics,and the potential that noncoding RNAs have as a prognostic and treatment tool. | William Wagstaff Rimel N.Mwamba Karina Grullon Mikhayla Armstrong Piao Zhao Bryce Hendren-Santiago Kevin H.Qin Alexander J.Li Daniel A.Hu Andrew Youssef Russell R.Reid Hue H.Luu Le Shen Tong-Chuan He Rex C.Haydon | 2022 | Genes & Diseases2022，9，6： | 2 |
| 2 | Fate of rigid fixation in pediatric craniofacial surgery显示文摘 | Berryhill WE Rimell FL Ness J | 1999 | Otolaryngol Head Neck Surg1999，121，3： | 1 |
| 3 | Disability caused by minor head injury 显示文摘 | Rimel RW Giordani B Barth JT | 1981 | Neurosurgery1981，9，3： | 1 |
| 4 | Disability caused by minor head iniury显示文摘 | Rimel RW Giardani B Barth JT | 1981 | Neurosurgery1981，9，3： | 1 |
| 5 | The role of neoadjuvant chemotherapy in the management of patients with advanced stage ovarian cancer : survey results from members of the society of gynecologic oncolo- gists 显示文摘 | Dewdney SB Rimel B J Reinhart AJ | 2010 | Gynecol Oncol2010，119，1： | 1 |
| 6 | Cine magnetic resonance imaging for evaluation of focal tracheomalacia:innominate artery compression syndrome显示文摘 | Faust RA Rimell FL Remley KB | 2002 | Int J Pediatr Otorhinolaryngol2002，65，： | 1 |
| 7 | Injuries of the hard palate and the horizontal buttress of the midface显示文摘 | Rimell F Marentette LJ | 1993 | Otolaryngol Head Neck Surg1993，109，31： | 1 |
| 8 | Ethmoidal Ce- mento-ossifying Fibroma:The Transglabellar/Subcranial Ap- proach显示文摘 | Cox V S Rimell F L Marenttete L J | 1996 | Otolaryngol Head Neck Surg1996，114，2： | 1 |
| 9 | Tracheotomy in children with juvenile-onset recurrent respiratory papillomatosis:the Children′s Hospital of Pittsburgh experience显示文摘 | SHAPIRO A M RIMELL F L SHOEMAKER D | 1996 | Ann Otol Rhinol Laryngol1996，105，： | 1 |
| 10 | A new visual acuity test on touchpad for vision screening in children显示文摘AIM:To validate a visual acuity(VA)test application on touchpad in the screening of pediatric population by comparing VA results obtained with conventional tests.METHODS:A cohort of 101 patients,44 girls and 57 boys with a median of 6.5 years old(3-10 years of age),presenting for eye examinations in Ophthalmology Department(Strasbourg,France)between November 1st,2018,and February 1st,2019 were enrolled.Monocular and binocular VA testing was performed on the subject using both a standard test and the touchpad application(Monoyer,'E'or,Pigassou depending of children s capacities).Patients were excluded if they were physically or mentally unable to use the touchpad.The duration of each tests,the painfulness,the comprehension,the attention of children during the test and test’s preferences were also evaluated.RESULTS:There was a good linear correlation and intra-class correlation coefficient[ICC=0.50(0.34.0.64)for binocular acuity,0.74(0.64.0.82)for right eyes and 0.525(0.37.0.66)for left eye].The standard errors of measurement were very low(0.08.0.05.0.08 for binocular VA,right eyes VA and left eyes VA,respectively).There was no difference between two tests for right eye(P=0.126);left eye(P=0.098)and binocular acuity(P=0.085).Non inferiority was proved for all binocular[-0.06(-0.09.-0.03)],right eye[-0.04(-0.07.-0.01)]and left eye[-0.06(-0.09,-0.02)]VA.The sensitivity and specificity,which correspond to the ability for our app to detect amblyopia,were 92%and 80%respectively.CONCLUSION:Our touchpad application represents an efficient and valid test of VA in children with a high specificity to detect visual impairment. | Elsa Di Foggia Noémie Stoll Hélène Meunier Adam Rimelé Pascal Ance Pierre-Henri Moreau Claude Speeg-Schatz Arnaud Sauer | 2020 | International Journal of Ophthalmology(English edition)2020，13，9： | 1 |
| 11 | Cochlear implantation in infants less than 12 months of age显示文摘 | Valencia DM Rimell FL Friedman BJ | 2008 | Int J Pediatr Otorhinolaryngol2008，72，6： | 1 |
| 12 | Diagnosis and management of pediatric tracheal stenosis 显示文摘 | Rimell FL Stool SE | 1995 | Otolaryngol Clin North Am1995，28，4： | 1 |
| 13 | Absence of MGMT pro- moter methylation in endometrial cancer 显示文摘 | Rimel B J Huettner P Powell MA | 2009 | Gynecol Oncol2009，112，1： | 1 |
| 14 | Infectious com- plications in pediatric cochlear implants 显示文摘 | Hopfenspirger MT Levine SC Rimell FL | 2007 | Laryngo- scope2007，117，10： | 1 |
| 15 | Risk factors for subarachnoid hemorrhagez: A systematic review 显示文摘 | Teunissen LL Rimel GJ Algra A | 1996 | Stroke1996，27，： | 1 |
| 16 | Ethmoidal cemento-ossifying fibroma:the transglabellar/subcranial approach显示文摘 | COX V S RIMELL F L MARENTTETE L J | 1996 | Otolaryngol Head Neck Surg1996，114，： | 1 |
| 17 | Moderate head injury, completing the clinical spectrum of brain trauma 显示文摘 | RIMEL R W GIORDANI B BARTH J T | 1982 | Neurosurgery1982，11，3： | 1 |
| 18 | Magnetic resonance imaging of the pediatric airway 显示文摘 | Rimell FL Shapiro AM Meza MP | 1997 | Arch Otolaryngol Head Neck Surg1997，123，9： | 1 |
| 19 | Fate of rigid fixation in pediatric craniofacial surgery显示文摘 | Berryhill WE Rimell FL Ness J | 1999 | Otolaryngol Head Neck Surg1999，121，3： | 1 |
| 20 | Cochlear implantation in infants less than 12 months of age显示文摘 | Valencia DM Rimell FL Friedman BJ | 2008 | Int J Pediatr Otorhinolaryngol2008，72，6： | 1 |
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