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| 1 | Bedside ultrasound in the diagnosis of nonalcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease in the United States.While the American Association for the Study of Liver Diseases guidelines define NAFLD as hepatic steatosis detected either on histology or imaging without a secondary cause of abnormal hepatic fat accumulation,no imaging modality is recommended as standard of care for screening or diagnosis.Bedside ultrasound has been evaluated as a non-invasive method of diagnosing NAFLD with the presence of characteristic sonographic findings.Prior studies suggest characteristic sonographic findings for NAFLD include bright hepatic echoes,increased hepatorenal echogenicity,vascular blurring of portal or hepatic vein and subcutaneous tissue thickness.These sonographic characteristics have not been shown to aid bedside clinicians easily identify potential cases of NAFLD.While sonographic findings such as attenuation of image,diffuse echogenicity,uniform heterogeneous liver,thick subcutaneous depth,and enlarged liver filling of the entire field could be identifiedby clinicians from bedside ultrasound.The accessibility,ease of use,and low-side effect profile of ultrasound make bedside ultrasound an appealing imaging modality in the detection of hepatic steatosis.When used with appropriate clinical risk factors and steatosis involves greater than 33%of the liver,ultrasound can reliably diagnose NAFLD.Despite the ability of ultrasound in detecting moderate hepatic steatosis,it cannot replace liver biopsy in staging the degree of fibrosis.The purpose of this review is to examine the diagnostic accuracy,utility,and limitations of ultrasound in the diagnosis of NAFLD and its potential use by clinicians in routine practices. | Nancy Khov Amol Sharma Thomas R Riley | 2014 | World Journal of Gastroenterology2014，20，22： | 11 |
| 2 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 3 | 多重结局的多元Meta分析和多重治疗的网状Meta分析:原理、概念及实例显示文摘英国国家健康与临床优选研究所(NICE)等组织需要对现有研究获得的证据进行整合来指导决策,需要确定关于多重疗效及安全性结局的最佳治疗。但是,相关的研究不一定对所有关注的治疗或结局都进行了直接比较,多元Meta分析及网状Meta分析为如何确定最佳治疗这一问题提供了思路,该方法不仅考虑了直接证据,还利用了关联或间接的证据。本文中,研究者描述了这些方法学的重要概念及假设,并阐述关联及间接证据如何产生,同时通过图表说明这些证据在涉及多重结局和多重治疗的真实临床案例中如何使用。 | Richard D Riley Dan Jackson Georgia Salanti Danielle L Burke Malcolm Price Jamie Kirkham Ian R White 孙至佳(译) 张岩(译) 刘雪晴(译) 杨智荣(校) 孙凤(校) | 2018 | 英国医学杂志中文版2018，21，12： | 2 |
| 4 | Governing the surgical count through communication interactions: implications for patient safety显示文摘 | RILEY R MANIAS E POLGLASE A | 2006 | Qual Saf Health Care2006，15，5： | 1 |
| 5 | The production and phonotupos of wheat-rye chromosome addition lines显示文摘 | Riley R Chapman V | 1958 | Heredity1958，12，： | 1 |
| 6 | Observation of the autumn migration of the rice leaf roller Cnahalocrocis medinalis (Lepidoptera: Pyralidae) and other moths in eastern china 显示文摘 | Riley J R Reynolds D R Smith A D | 1995 | Bull Ent Res1995，85，： | 1 |
| 7 | Radiofrequency volumetrictissue reduction of the palate in subjects with sleep-disorderedbreathing显示文摘 | Powell N B Riley R W Troell R J | 1998 | Chest1998，113，： | 1 |
| 8 | Pal- atability of beef from steer and young bull car-casses as influenced by electrical stimulation, subcutaneous fat thickness and marbling 显示文摘 | RILEY R R SAVELL J W MURPHEY C E | 1983 | Journal of Animal Science1983，56，3： | 1 |
| 9 | Collecting and analyzing cord blood gases 显示文摘 | Riley R J Johnson JWC | 1993 | Clin Obstet Gynecol1993，36，1： | 1 |
| 10 | Expression of Sendai virus nucleocapsid protein in a baculovirus expression system and application to diagnostic assays for Sendai virus infection显示文摘 | Wan C H Riley M I Hook R R Jr | 1995 | J Clin Microbiol1995，33，： | 1 |
| 11 | Performance assessment of a nuclear waste repository: Upscaling coupled hydro-mechanical properties for far-field transport analysis 显示文摘 | Blum P Mackay R Riley M S Knight J L | 2005 | International Journal of Rock Mechanics and Mining Sciences2005，42，56： | 1 |
| 12 | Temporal changes in the prevalence of community-acquired anti- microbial-resistant urinary tract infection affected by Escherichia eoli clonal group composition显示文摘 | SMITH S P MANGES A R RILEY L W | 2008 | Clin In- feet Dis2008，46，： | 1 |
| 13 | Treatment of full-thickness abdominal and chest wall losses with split-thickness skin grafting显示文摘 | Barrett BM Jr Millard R Jr Riley WB Jr | | 0，，02： | 1 |
| 14 | The prognostic significance of the morning blood pressure 1 surge in clinical practice:a systematic re-view显示文摘 | Sheppard JP Hodgkinson J Riley R | 2015 | Am J Hypertens2015，28，1： | 1 |
| 15 | Haploid Angiosperms显示文摘 | Kimber G Riley R | 1963 | Botanical Review1963，29，： | 1 |
| 16 | Cytokines and the regulation of apoptosis in reproductive tissues: a review显示文摘 | Riley S C Antipatis C | 1999 | Am J Reprod Immunol1999，42，2： | 1 |
| 17 | A here dimensional osteochondral composite scaffold for articular cartilage repair显示文摘 | SHERWOOD J K RILEY S L PALAZZOLO R | 2002 | Biomaterials2002，23，： | 1 |
| 18 | Assessment of river health: Accounting for perturbation pathways in physical and ecological space显示文摘 | TOWNSEND C R RILEY R H | 1999 | Freshwater Biology1999，41，： | 1 |
| 19 | Late Jurassic macrosofossil assemblage from Jason Peninsula,Graham Land:evidence for a significant northward extension of the Latady Formation显示文摘 | RILEY T R CRAME J A THOMSON M R A | 1997 | Antartic Science1997，9，4： | 1 |
| 20 | Bone morpho- genetic protein-2: biology and applications 显示文摘 | RILEY E H LANE J M URIST M R | 1996 | Clin Orthop Relat Res1996，，39： | 1 |
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