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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Cardiac arrhythmias and cardiac arrest related to mushroom poisoning: A case report显示文摘BACKGROUND Mushroom exposure is a global health issue.The manifestations of mushroom poisoning (MP) may vary.Some species have been reported as rhabdomyolytic,hallucinogenic,or gastrointestinal poisons.Critical or even fatal MPs are mostly attributable to Amanita phalloides,with the development of severe liver or renal failure.Myocardial injury and even cases mimicking ST-segment elevation myocardial infarction (STEMI) have been previously reported,while cardiac arrhythmia or cardiac arrest is not commonly seen.CASE SUMMARY We report a 68-year-old woman with MP who suffered from delirium,seizure,long QT syndrome on electrocardiogram (ECG),severe cardiac arrhythmias of multiple origins,and cardiac arrest.She was intubated and put on blood perfusion.Her kidney and liver functions were intact;creatine kinase-MB was mildly elevated,and then fell within normal range during her hospital stay.We sent the mushrooms she left for translation elongation factor subunit 1α,ribosomal RNA gene sequence,and internal transcribed spacer sequence analyses.There were four kinds of mushrooms identified,two of which were found to be toxic.CONCLUSION This is the first time that we found cardiac toxicity caused by Panaeolus subbalteatus and Conocybe lactea,which were believed to be toxic to the liver,kidney,and brain.We suggest that intensive monitoring and ECG follow-up are essential to diagnose prolonged QT interval and different forms of tachycardia in MP patients,even without the development of severe liver or renal failure.The mechanisms need to be further investigated and clarified based on animal experiments and molecular signal pathways. | Shu Li Qing-Bian Ma Ci Tian Hong-Xia Ge Yang Liang Zhi-Guo Guo Cheng-Duo Zhang Bei Yao Jia-Ning Geng Fran Riley | 2019 | World Journal of Clinical Cases2019，7，16： | 4 |
| 3 | Investigations into the failure of dental magnets显示文摘 | Riley MA | 1999 | Int J Prosthodont1999，2，3： | 1 |
| 4 | MR imaging of anterior cruciate ligament injury:independent value of primary and secondary signs显示文摘 | Brandser EA Riley MA Berbaum KS | 1996 | AJR1996，167，1： | 1 |
| 5 | Magnets in prosthetic dentistry显示文摘 | Riley MA Walmsley AD Harris IR | 2001 | J Prosthet Dent2001，86，2： | 1 |
| 6 | MR imaging of anterior cruciate ligament injury:independent value of primary and secondary signs显示文摘 | Brandser EA Riley MA Berbaum KS | 1996 | AJR1996，167，1： | 1 |
| 7 | MR imaging of anterior cruciate ligament injury:independent value of primary and secondary signs显示文摘 | Brangser EA Riley MA Berbaum KS | 1996 | AJR1996，167，1： | 1 |
| 8 | Magnets in prosthetic dentistry 显示文摘 | Riley MA Walmsley AD Haris IR | 2001 | J Prosthet Dent2001，86，： | 1 |
| 9 | Magnets in prosthetic dentistry显示文摘 | Riley MA Walmsley AD Harris IR | 2001 | Prosthet Dent2001，86，2： | 1 |
| 10 | Magnets in prosthetic dentistry显示文摘 | Riley MA Walmsley AD Haris IR | 2001 | J Prosthet Dent2001，86，： | 1 |
| 11 | V-Src-induced modulation of the calpain-calpastatin proteolytic system regulates translation显示文摘 | Carragher NO Westhoff MA Riley D | 2002 | Mol Cell Biol2002，22，： | 1 |
| 12 | Magnets in prosthetic dentistry显示文摘 | Riley MA Walmsley AD Harris IR | 2001 | J Prosthet Dent2001，86，2： | 1 |
| 13 | MR imaging of ante- rior crueiate ligament injury: independent value of primary and secondary signs显示文摘 | Brandser EA Riley MA Berbaum KS | 1996 | A JR Am J Roentgenol1996，167，1： | 1 |
| 14 | Magnets in prosthetic dentistry显示文摘 | Riley MA Walmsley AD Harris IR | 2001 | J Prosthet Dent2001，86，2： | 1 |
| 15 | Stimulation of in vivo angiogenesis using dual growth factor-loaded crosslinked glycosarmn glycan hydrogels显示文摘 | Riley CM Fuegy PW Firpob MA | | 0，，： | 1 |
| 16 | Histamine H4 receptor an-tagonism diminishes existing airwayinflammation and dysfunctionvia modulation of Th2 cytokines显示文摘 | COWDEN JM RILEY JP MA JY | 2010 | Respir Res2010，11，： | 1 |
| 17 | Investigations into the failure of dental magnets显示文摘 | Riley MA Williams AJ Speight JD | 1999 | Int J Prosthodont1999，2，： | 1 |
| 18 | Magnets in prosthetic dentistry显示文摘 | Riley MA Walmsley AD Harris IR | 2001 | J Prosthet Dent2001，86，2： | 1 |
| 19 | Activation of cyclinD1-cdk4 and cdk4-derived phosphorylation of RB protein in diabetic mesangial hypertrophy 显示文摘 | Feliers D Frank MA Riley DJ | 2002 | Diabetes2002，51，11： | 1 |
| 20 | Amniotic fluid interleukin-6 and preterm delivery : a review 显示文摘 | EL-Bastawissi AY Williams MA Riley DE | 2000 | Obstet Gynecol2000，95，6： | 1 |
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