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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Thermal hypersensitivity in a subset of irritable bowel syndrome patients显示文摘AIM:To characterize thermal hypersensitivity in patients with constipation-and diarrhea-predominant irritable bowel syndrome (IBS).METHODS:Thermal pain sensitivity was tested among patients with diarrhea-predominant IBS (D-IBS) and constipation-predominant IBS (C-IBS) compared to healthy subjects.A total of 42 patients (29 female and 13 male;mean age 27.0±6.4 years) with D-IBS;24 patients (16 female and eight male;mean age 32.5±8.8 years) with C-IBS;and 52 control subjects (34 female and 18 male;mean age 27.3±8.0 years) participated in the study.Thermal stimuli were delivered using a Medoc Thermal Sensory Analyzer with a 3 cm × 3 cm surface area.Heat pain threshold (HPTh) and heat pain tolerance (HPTo) were assessed on the left ventral forearm and left calf using an ascending method of limits.The Functional Bowel Disease Severity Index (FBDSI) was also obtained for all subjects.RESULTS:Controls were less sensitive than C-IBS and D-IBS (both at P < 0.001) with no differences between C-IBS and D-IBS for HPTh and HPTo.Thermal hyperalgesia was present in both groups of IBS patients relative to controls,with IBS patients reporting significantly lower pain threshold and pain tolerance at both test sites.Cluster analysis revealed the presence of subgroups of IBS patients based on thermal hyperalgesia.One cluster (17% of the sample) showed a profile of heat pain sensitivity very similar to that of healthy controls;a second cluster (47% of the sample) showed moderate heat pain sensitivity;and a third cluster (36% of the sample) showed a very high degree of thermal hyperalgesia.CONCLUSION:A subset of IBS patients had thermal hypersensitivity compared to controls,who reported significantly lower HPTh and HPTo.All IBS patients had a higher score on the FBDSI than controls.Interestingly,the subset of IBS patients with high thermal sensitivity (36%) had the highest FBDSI score compared to the other two groups of IBS patients. | QiQi Zhou Roger B Fillingim Joseph L Riley Ⅲ G Nicholas Verne | 2009 | World Journal of Gastroenterology2009，15，26： | 2 |
| 3 | 多重结局的多元Meta分析和多重治疗的网状Meta分析:原理、概念及实例显示文摘英国国家健康与临床优选研究所(NICE)等组织需要对现有研究获得的证据进行整合来指导决策,需要确定关于多重疗效及安全性结局的最佳治疗。但是,相关的研究不一定对所有关注的治疗或结局都进行了直接比较,多元Meta分析及网状Meta分析为如何确定最佳治疗这一问题提供了思路,该方法不仅考虑了直接证据,还利用了关联或间接的证据。本文中,研究者描述了这些方法学的重要概念及假设,并阐述关联及间接证据如何产生,同时通过图表说明这些证据在涉及多重结局和多重治疗的真实临床案例中如何使用。 | Richard D Riley Dan Jackson Georgia Salanti Danielle L Burke Malcolm Price Jamie Kirkham Ian R White 孙至佳(译) 张岩(译) 刘雪晴(译) 杨智荣(校) 孙凤(校) | 2018 | 英国医学杂志中文版2018，21，12： | 2 |
| 4 | Sodium-assisted oxidation of reactionbonded silicon nitride显示文摘 | Mayer M Riley F L | 1978 | Mater Sci1978，13，： | 1 |
| 5 | PD-1 signaling in primary T cells显示文摘 | Riley J L | 2009 | Immunol Rev2009，229，： | 1 |
| 6 | The Seasat Scanning Multichannel Microwave Radiometer(SMMR):Radio-metric Calibration Algorithm Development and Perfo-rmance显示文摘 | SWANSON P RILEY A L | 1980 | IEEE Journal of Oceanic Engineering1980，5，2： | 1 |
| 7 | Genetically engineered bacteriocins and their potential as the next generation of antimierobials显示文摘 | GILLOR O NIGRO L M RILEY M A | 2005 | Current Pharmaceutical Design2005，11，： | 1 |
| 8 | CIMO Ligand (CD154) triggers ashort-term CD4+ T cell aetivition response that results in secretion of immunomodulatory cytokines and apoptosis显示文摘 | Blair P J Riley J L Harlan D M | 2000 | J Exp Med2000，191，4： | 1 |
| 9 | Decreased thin filament density and length in human atrophic soleus muscle fibers after spaceflight显示文摘 | Riley D A Bain J L Thompson J L | 2000 | J Appl Physiol2000，88，2： | 1 |
| 10 | Performance assessment of a nuclear waste repository: Upscaling coupled hydro-mechanical properties for far-field transport analysis 显示文摘 | Blum P Mackay R Riley M S Knight J L | 2005 | International Journal of Rock Mechanics and Mining Sciences2005，42，56： | 1 |
| 11 | Temporal changes in the prevalence of community-acquired anti- microbial-resistant urinary tract infection affected by Escherichia eoli clonal group composition显示文摘 | SMITH S P MANGES A R RILEY L W | 2008 | Clin In- feet Dis2008，46，： | 1 |
| 12 | Modeling the components of the brand显示文摘 | Chernatony L Riley F.D | | 0，，11： | 1 |
| 13 | Epidural hematoma after immobilization of a Hangman’s fracture:case report and review of the literature显示文摘 | Buchowski J M Riley L H | 2005 | Spine J2005，5，： | 1 |
| 14 | A here dimensional osteochondral composite scaffold for articular cartilage repair显示文摘 | SHERWOOD J K RILEY S L PALAZZOLO R | 2002 | Biomaterials2002，23，： | 1 |
| 15 | The polymerization of methylglyoxal显示文摘 | de V Moulds L Riley H L | 1938 | J Chem Soc1938，，： | 1 |
| 16 | In?uence of age on dynamics of rising from a chair 显示文摘 | IKEDA E R SCHENKMAN M L RILEY P O | 1991 | PhysicalTherapy1991，71，1： | 1 |
| 17 | Mechanical proper- ties of magnesispinel composites 显示文摘 | AKSEL C RAND B RILEY F L | 2002 | J Eur Ceram Soc2002，22，5： | 1 |
| 18 | Wildland fire e- missions, carbon, and climate: Seeing the forest and the trees A cross-scale assessment of wildfire and carbon dynamics in fire-prone, forested ecosystems 显示文摘 | Loehman A Reinhardt E Riley L | 2014 | Forest Ecology and Management2014，317，1： | 1 |
| 19 | Hemorrhagic colitis associated with a rare Escherichia coli serotype显示文摘 | RILEY L W REMIS R S HELGERSON S D | 1983 | New England Journal of Medicine1983，308，12： | 1 |
| 20 | Phosphorylation of the mitotie regulator protein Hecl by Nek2 kinase is essential for faithful chromosome segregation显示文摘 | Chen Y Riley DJ Zheng L | 2002 | J Biol Chem2002，277，49： | 1 |
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