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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 3 | Interinstitutional and intrainstitutional transmission of a strain of Acineto- bacter baumanniidetected by molecular analysis: compari- son of pulsed-field gel electrophoresis and repetitive se- quence-based polymerase chain reaction 显示文摘 | Saeed S Fakih M G Riederer K | 2006 | Infect Con- trol Hosp Epidemiol2006，27，9： | 1 |
| 4 | CYP4F2 is a vitamin K1 oxidase: an explanation for altered warfarin dose in carriers of the V433M variant显示文摘 | MCDDNALD MG RIEDER MJ NAKANO M | 2009 | Mol Pharmacol2009，75，6： | 1 |
| 5 | The Effect of Material Transfer in Relays Diagnosed by Force and/or Voltage Measurement显示文摘 | NEUHAUS A R RIEDER W F | 2004 | IEEE Transactions on Components and Packaging Technologies2004，27，1： | 1 |
| 6 | Visualization of risk structures for interactive planning of image guided radiofre quency ablation of liver tumors显示文摘 | Rieder C Schwier M Weihusen A | 2009 | Proc SHE2009，7261，： | 1 |
| 7 | Tumor necrosis factor-α(TNF-α)increase both in the brain and in the cerebrospinal fluid from parkinsonian patients显示文摘 | MOGI M HARADA M RIEDERER P | 1994 | Neurosci Lett1994，165，81： | 1 |
| 8 | The foot-and-mouth disease virus leader proteinase gene is not required for viral replication显示文摘 | Piccone M E Rieder E Mason P W | 1995 | J Virol1995，69，： | 1 |
| 9 | Innovation manage- ment: an overview and some best practices 显示文摘 | Riederer J P Baier M Graefe G | 2005 | The Cooperative Computing & Cooperation Laboratory Report2005，4，3： | 1 |
| 10 | The role of the ubiquitinproteasome system in Alzheimer, s disease显示文摘 | Riederer B M Leuba G Vemay A | 2011 | Exp Biol Med ( May-wood)2011，236，3： | 1 |
| 11 | Long-chain alkanediols,ketoaldehydes,ketoalcohols and ketoalkyl esters in the cuticular waxes of Osmunda regalis fronds显示文摘 | Jetter R Riederer M | 1999 | Phytochemistry1999，52，5： | 1 |
| 12 | Arsenic in iron disulfides in a brown coal from the North Bohemian Basin, Czech Republic显示文摘 | RIEDER M CRELLING J C SUSTAI O | 2007 | International Journal of Coal Geology2007，71，： | 1 |
| 13 | Tumor necrosis factor-alpha(TNF- alpha) increases both in the brain and in the cerebrospinal fluid from Parkinson's patients显示文摘 | Mogi M Harada M Riederer P | 1994 | Neurosci Lett1994，165，： | 1 |
| 14 | Effect of VKORC 1 haplo- types on transcriptional regula'tion and warfarin dose 显示文摘 | Rieder M J Reiner AP Gage BF | 2005 | N Engl J Med2005，352，22： | 1 |
| 15 | Synthetic aperture focusing of ultrasonic inspection data to enhance the probability of detection of defects in strongly attenuating materi- als显示文摘 | SPIES M RIEDER H | 2010 | NDTIE Int2010，，43： | 1 |
| 16 | Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium 显示文摘 | Carlson CS Eberle MA Rieder M J | 2004 | Am J Hum Genet2004，74，1： | 1 |
| 17 | In plant contamination modelingand simulation of organic chemical processes显示文摘 | RIEDERER M TRAPP S MC FARLANE J C | 1994 | Boca Raton1994，，： | 1 |
| 18 | Tumor necrosis factor-alpha increases both in the brain and in the cerebrospinal fluid from parkin sonian patients显示文摘 | Mogi M Harada M Riederer P | 1994 | Neurosci Lett1994，165，： | 1 |
| 19 | The effect of material transfer in relays diagnosed by force and/or voltage measurement显示文摘 | Hammerschmidt M Neuhaus A R Rieder W F | 2004 | IEEE Transactions on Components and Packaging Technologied2004，27，1： | 1 |
| 20 | Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium 显示文摘 | CARLSON S C EBERLE M A RIEDER M J | 2004 | Am J Hum Genet2004，74，1： | 1 |
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