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69篇 您的检索式:作者名="Riddle S"
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1In vivo radiometric analysis of glucose uptake and distribution in mouse bone显示文摘Bone formation and remodeling occurs throughout life and requires the sustained activity of osteoblasts and osteoclasts,particularly during periods of rapid bone growth.Despite increasing evidence linking bone cell activity to global energy homeostasis,little is known about the relative energy requirements or substrate utilization of bone cells.In these studies,we measured the uptake and distribution of glucose in the skeleton in vivo using positron-emitting^(18)F-fluorodeoxyglucose([^(18)F]-FDG) and non-invasive,high-resolution positron emission tomography/computed tomography(PET/CT) imaging and ex vivo autoradiography.Assessment of [^(18)F]-FDG uptake demonstrated that relative to other tissues bone accumulated a significant fraction of the total dose of the glucose analog.Skeletal accumulation was greatest in young mice undergoing the rapid bone formation that characterizes early development.PET/CT imaging revealed that [^(18)F]-FDG uptake was greatest in the epiphyseal and metaphyseal regions of long bones,which accords with the increased osteoblast numbers and activity at this skeletal site.Insulin administration significantly increased skeletal accumulation of [^(18)F]-FDG,while uptake was reduced in mice lacking the insulin receptor specifically in osteoblasts or fed a high-fat diet.Our results indicated that the skeleton is a site of significant glucose uptake and that its consumption by bone cells is subject to regulation by insulin and disturbances in whole-body metabolism.Meredith L Zoch Diane S Abou Thomas L Clemens Daniel LJ Thorek Ryan C Riddle 2016Bone Research2016,4,1:9
2Maturation-dependent vulnerability of perinatal white matter in premature birth 显示文摘Back S A Riddle A McClure M M 2007Stroke2007,38,2:1
3Focused ion beam milling:A practical method for preparing cast Al-Si alloy samples for transmission electron microscopy 显示文摘SHANKAR S RIDDLE Y MAKHLOUF M M 2003Metallurgical and Materials Transactions A2003,34,3:1
4An external landmark for the anterior commissure 显示文摘ADAMS J GROSS N RIDDLE S 1999Laryngoscope1999,109,7:1
5Structural basis for the specificity of ubiquitin C-terminal hydrolases 显示文摘JOHNSTON S C RIDDLE S M COHEN R E 2000EMBO J2000,18,14:1
6Hypoxia induces hexokinase II gene expression in human lung cell line A549 显示文摘Riddle SR Ahmad A Ahmad S 2000Am J Physiol Lung Cell Mol Physiol2000,278,2:1
7Experiment and theory highlight role of native state topolopy in SH3 folding显示文摘RIDDLE D S GRANTCHAROVA V P SANTIAGO J V 1999Nat Struct Biol1999,6,11:1
8Hypoxia induces hexokinase 2 gene expression in human lung cell line A549显示文摘Riddle SR Ahmad A Ahmad S 2000Am J Physiol Lung Cell Mol Physiol2000,,:1
9Efficacy of glyphosate and five surfactants for controlling giant salvinia显示文摘Fairchild J F Allert A L Riddle J S 2002J Aquat Plant Manage2002,40,:1
10Effects of contaminants in the Antarctic environment-potential of the gammarid amphipod crustacean Paramorea walkeri as a biological indicator for Antarctic ecosystems based on toxicity and bioacccumulation of copper and cadmium 显示文摘Duquesne S Riddle M Schulz R 2000Aquatic Toxicology2000,49,:1
11Successful treatment with injected hyaluronic acid in a patient with lip asymmetry after surgical correction of cleft lip显示文摘SCHWE1GER E S RIDDLE C C TONKOVI-CAPIN V 2008Dermatol Surg2008,34,5:1
12Notes on economic plants 显示文摘Outlaw W H Zhang S Q Riddle K A 2002Economic Botany2002,56,2:1
13Nucleation mechanism of the eutectic phases in aluminum-silicon hypoeutectic alloys 显示文摘Shankar S Riddle Y W MakhloufM M 2004Aeta Materialia2004,52,15:1
14Measurement of optic disc size and rim area with spectral-domain OCT and scan- ning laser ophthalmoscopy显示文摘Moghimi S Hosseini H Riddle J 2012Invest Ophthalmol Vis Sci2012,53,8:1
15Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition显示文摘Fulzele K Riddle RC DiGirolamo DJ Cao X Wan C Chen D Faugere MC Aja S Hussain MA Brüning JC Clemens TL 0,,2:1
16Effect of adjunctive loperamide in combination with antibiotics on treatment outcomes in traveler’s diarrhea:a systematic review and meta-analysis显示文摘Riddle MS Arnold S Tribble DR 2008Clin Infect Dis2008,47,8:1
17Characterisation of the dilute HCI extraction method for the identification of metal contamination in Antarctic marine sedi- ments显示文摘Snape I Scouller R C Stark S C Stark J Riddle M J 2004Chemosphere2004,57,6:1
18Estimating the Capacity of Freight Transportation Systems: A Model and Its Application in Transport Planning and Logistics显示文摘MORLOK E K RIDDLE S P 1999Transportation Research Record1999,,1653:1
19Measurement of optic disc size and rim area with spectral-domain OCT and scanning laser ophthalmoscopy显示文摘Moghimi S Hosseini H Riddle J 2012Invest Ophthalmol Vis Sci2012,53,8:1
20Sensory control of dauer larva formation in Caenorhabditis elegans 显示文摘ALBERT P S BROWN S J RIDDLE D L 1981Journal of Comparative Neurology1981,198,3:1
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