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| 1 | 镁合金表面耐蚀改性技术显示文摘镁及镁合金是一种极具发展潜力的轻质结构材料,但镁合金的耐蚀性较差,因此进行适当的表面处理以提高镁合金的耐蚀性能已成为目前研究的热点。微弧氧化、激光表面处理、离子注入、物理气相沉积(PVD)及等离子体注入沉积(IBAD)是近年来兴起的镁合金表面耐蚀强化新技术,这几种技术在处理镁合金耐蚀性方面已取得了一定的成果。综述了目前国内外应用这几种方法提高镁合金耐蚀性方面的研究现状,并展望了其应用前景。 | 韦春贝 张春霞 田修波 杨士勤 Ricky Fu Paul K.Chu | 2004 | 轻合金加工技术2004，32，6： | 18 |
| 2 | IDO1 in cancer: a Gemini of immune checkpoints显示文摘Indoleamine 2,3-dioxygenase 1(IDO1)is a rate-limiting metabolic enzyme that converts the essential amino acid tryptophan(Trp)into downstream catabolites known as kynurenines.Coincidently,numerous studies have demonstrated that IDO1 is highly expressed in multiple types of human cancer.Preclinical studies have further introduced an interesting paradox:while single-agent treatment with IDO1 enzyme inhibitor has a negligible effect on decreasing the established cancer burden,approaches combining select therapies with IDO1 blockade tend to yield a synergistic benefit against tumor growth and/or animal subject survival.Given the high expression of IDO1 among multiple cancer types along with the lack of monotherapeutic efficacy,these data suggest that there is a more complex mechanism of action than previously appreciated.Similar to the dual faces of the astrological Gemini,we highlight the multiple roles of IDO1 and review its canonical association with IDO1-dependent tryptophan metabolism,as well as documented evidence confirming the dispensability of enzyme activity for its immunosuppressive effects.The gene transcript levels for IDO1 highlight its strong association with T-cell infiltration,but the lack of a universal prognostic significance among all cancer subtypes.Finally,ongoing clinical trials are discussed with consideration of IDO1-targeting strategies that enhance the efficacy of immunotherapy for cancer patients。 | Lijie Zhai Erik Ladomersky Alicia Lenzen Brenda Nguyen Ricky Patel Kristen L Lauing Meijing Wu Derek A Wainwright | 2018 | Cellular & Molecular Immunology2018，15，5： | 17 |
| 3 | The role of vascular endothelial growth factor in ossification显示文摘Osteogenesis and angiogenesis are two closely correlated processes during bone growth,development,remodelling and repair. Vascular endothelial growth factor (VEGF) is an essential mediator during the process of angiogenesis. Based on an extensive literature search,which was carried out using the PubMed database and the Keywords of osteogenesis, VEGF, endochondral ossification and intramembranous ossification, this manuscript reviews the role of VEGF in ossification, with emphasis on its effect in endochondral and intramembranous ossification. Osteogenesis and angiogenesis are closely correlated processes. VEGF acts as an essential mediator during these processes. It not only functions in bone angiogenesis but also in various aspects of bone development. | Yan-Qi Yang Ying-Ying Tan Ricky Wong Alex Wenden Lin-Kun Zhang A bakr M Rabie | 2012 | International Journal of Oral Science2012，4，2： | 14 |
| 4 | 高功率脉冲磁控溅射的阶段性放电特征显示文摘本文从放电靶电流出发,采用一种新的研究方法,即将靶电流分解为多个代表具体放电特性的特征参数,全面而系统的研究了不同的工作气压条件下,靶电流各特征参数随靶电压的增加而进行的演化.结果发现高功率脉冲磁控溅射技术(HPPMS)放电靶电流在靶电压由低向高增加的过程中,出现靶电流峰值和平台值的交替变化,体现出明显的阶段性放电特征,且不同的放电阶段在不同气压下出现一定的移动,会在测量范围内出现某些放电阶段的缺失.本文还通过等离子体发射光谱对HPPMS放电靶前等离子体测量发现五个不同的放电阶段分别主要对应氩原子、铬原子、氩离子、铬离子和氩、铬高价离子的放电,但不同的放电条件下相邻的阶段会出现一定程度的交叠. | 吴忠振 田修波 李春伟 Ricky K.Y.Fu 潘锋 朱剑豪 | 2014 | 物理学报2014，63，17： | 12 |
| 5 | Factors associated with incomplete small bowel capsule endoscopy studies显示文摘AIM:To identify patient risk factors associated with incomplete small bowel capsule endoscopy(CE) studies.METHODS:Data from all CE procedures performed at St.Paul's Hospital in Vancouver,British Columbia,Canada,between December 2001 and June 2008 were collected and analyzed on a retrospective basis.Data collection for complete and incomplete CE study groups included patient demographics as well as a number of potential risk factors for incomplete CE including indication for the procedure,hospitalization,diabetes mellitus with or without end organ damage,limitations in mobility,renal insufficiency,past history of bowel obstruction,abdominal surgery,abdominal radiation therapy and opiate use.Risk factors were analyzed using a univariable and multivariable logistic regression model.RESULTS:From a total of 535 CE procedures performed,158 were incomplete(29.5%).The univariable analysis showed that CE procedures performed for overt gastrointestinal bleeding(P = 0.002),and for patients with a prior history of abdominal surgery(P = 0.023) or bowel obstruction(P = 0.023) were significantly associated with incomplete CE studies.Patients on opiate medications(P = 0.094) as well as hospitalized patients(P = 0.054) were not statistically significant,but did show a trend towards incomplete CE.The multivariable analysis showed that independent risk factors for an incomplete CE procedure include prior history of bowel obstruction [odds ratios(OR) 2.77,P = 0.02,95% confidence intervals(CI):1.17-6.56] and procedures performed for gastrointestinal bleeding(Occult OR 2.04,P = 0.037,95% CI:1.04-4.02 and Overt OR 2.69,P = 0.002,95% CI:1.44-5.05).Patients with a prior history of abdominal surgery(OR 1.46,P = 0.068,95% CI:0.97-2.19),those taking opiate medications(OR 1.54,P = 0.15,95% CI:0.86-2.76) and hospitalized patients(OR 1.82,P = 0.124,95% CI:0.85-3.93) showed a trend towards statistical significance.CONCLUSION:We have identified a number of risk factors for incomplete CE procedures that can be used to risk-stratify patients and guide interventions to improve completion rates. | Mitchell M Lee Andrew Jacques Eric Lam Ricky Kwok Pardis Lakzadeh Ajit Sandhar Brandon Segal Sigrid Svarta Joanna Law Robert Enns | 2010 | World Journal of Gastroenterology2010，16，42： | 10 |
| 6 | 等离子体浸没离子注入(PIII)过程中初始离子阵鞘层尺度内各物理量的时空演化显示文摘等离子体浸没离子注入(PIII)是用于材料表面改性的一种较新的、廉价的、非视线的技术。靶体被浸没在等离子体中,等离子体中的离子在靶体负脉冲偏压的作用下注入靶体而实现材料的表面改性。为了描述等离子体浸没离子注入过程,我们引用了一维粒子模型(PIC)对其进行了数值模拟,该模型通过求解空间电势的Poisson方程,电子的Bolzmann分布以及离子在网格中受力运动的Newton运动方程来完成。本文重点研究了一个初始离子阵鞘层内电势、离子浓度、离子注入靶体的速度和动能以及离子流密度的时空演化规律。 | 黄永宪 田修波 杨士勤 黄志俊 Ricky Fu Paul K.Chu | 2005 | 真空科学与技术学报2005，25，2： | 10 |
| 7 | Functional Characterization and RNAi-Mediated Suppression Reveals Roles for Hexose Transporters in Sugar Accumulation by Tomato Fruit显示文摘Hexoses 积累到高集中(200 ? 公里) 在西红柿的存储实质房间水果。Hexoses 作为进口韧皮部的蔗糖的水解作用产品从水果 apoplasm 被采购。三 hexose transporters (LeHT1, LeHT2, LeHT3 ) ,在水果存储实质房间表示了,可以由这些房间贡献 hexose 举起。他们的全身的序列的分析证明所有三 transporters 属于 monosaccharide transporters 的 STP 亚科本地化到血浆膜。LeHT1 的 Heterologous 表示(并且以前 LeHT2,齿轮等, 2000 ) ,然而并非 LeHT3,救了 hexose 损害运输的酵母异种当在葡萄糖上涨了时或象唯一的碳来源果糖。生物化学地, LeHT1,同样到 LeHT2,与高亲密关系的 glucose/H+ symporter 一致的展出运输性质。显著地, LeHT1 和 LeHT2 也与水果纸巾的与那些同量的明显的 Km 价值作为低亲密关系的 fructose/H+ symporters 工作了。在所有 LeHT 基因由的水果表示层次的实质的减小(8090%)调停 RNAi 击倒在水果 hexose 累积引起了 55% 减少。相反,由来源叶子的 photoassimilate 生产和到水果的韧皮部运输能力由 transporter 是未受影响的击倒。一起,这些调查结果证明 LeHTs 玩在在西红柿水果开发期间驾驶 hexoses 的累积进存储实质房间给角色调音。 | David W. McCurdy Stephen Dibley Ricky Cahyanegara Antony Martin John W. Patrick | 2010 | Molecular Plant2010，3，6： | 7 |
| 8 | 脉冲偏压上升沿特性对等离子体浸没离子注入鞘层扩展动力学的影响显示文摘等离子体浸没离子注入(PIII)是用于材料表面改性的一种廉价高效、非视线的技术.采用等离子体粒子模型,通过假设电子密度服从Boltzmann分布,求解Poisson方程和Newton方程,跟踪离子在等离子体鞘层中的运动形态及特性并进行统计分析,研究了不同上升速率和形状的6种波形上升沿对鞘层时空演化、离子注入能量和剂量的影响.结果表明,在PIII过程中,脉冲上升沿影响了等离子体鞘层的扩展,且不同波形诱导的鞘层厚度间存在最大差值.电场强度在鞘层的外边缘区域存在陡降区,离子的运动为非匀加速过程.可以通过调整脉冲波形上升沿特性实现离子注入能量和剂量的优化,数值仿真可以有效地为电源设计和工艺优化提供依据. | 黄永宪 田修波 杨士勤 Fu Ricky Chu K.Paul | 2007 | 物理学报2007，56，8： | 7 |
| 9 | Contents of four active components in different commercial crude drugs and preparations of Danshen (Salvia miltiorrhiza)显示文摘AIM:To detect the contents of four active components of Salvia miltiorrhiza in various commercially available danshen crude drugs and preparations.METHODS:Commercially available danshen crude drugs from different sources,as well as danshen pills and intravenous injection preparations containing danshen alone or in combination with other herbs were collected.The composition of these danshen samples was analyzed using HPLC.Specifically,the amounts of magnesium tanshinoate B(MTB),danshensu,isotanshinone IIA,and cryptotanshinone were determined.In some of these samples,the content of MTB was further confirmed by liquid chromatography-tandem mass spectrometer (LC-MS)/MS method.RESULTS:There were great variations in the amount of the four active ingredients in the commercially available danshen crude drugs and drug preparations in this study.The amount of MTB was the highest among the four components measured in the crude drugs.However,the amounts of MTB in all danshen preparations were much lower than those in crude drugs.The 2 lipophilic components,isotanshinone IIA and cryptotanshinone,were very low or not detectable in both injection and oral preparations.CONCLUSION:MTB can be used to standardize the various forms of danshen crude drugs and drug preparations from different sources.In view of the variation in the amounts of MTB and other components,improvement in the production methods of danshen preparations is essential to ensure consistent amount of its active ingredients and reproducible pharmacological actions. | Susan Wai Sum LEUNG Yaw Loong SIOW Ricky Ying Keung MAN | 2002 | Acta Pharmacologica Sinica2002，23，12： | 6 |
| 10 | Tuning Superhydrophobic Materials with Negative Surface Energy Domains显示文摘Hydrophobic/superhydrophobic materials with intrinsic water repellence are highly desirable in engineering fields including antiicing in aerocrafts,antidrag and anticorrosion in ships,and antifog and self-cleaning in optical lenses,screen,mirrors,and windows.However,superhydrophobic material should have small surface energy(SE)and a micro/nanosurface structure which can reduce solid-liquid contact significantly.The low SE is generally found in organic materials with inferior mechanical properties that is undesirable in engineering.Intriguingly,previous theoretical calculations have predicted a negative SE forθ-alumina(θ-Al_(2)O_(3)),which inspires us to use it as a superhydrophobic material.Here,we report the experimental evidence of the small/negative SE ofθ-Al_(2)O_(3) and aθ-Al_(2)O_(3)-based superhydrophobic coating prepared by one-step scalable plasma arcing oxidation.The superhydrophobic coating has complete ceramic and desired micro/nanostructure and therefore exhibits excellent aging resistance,wear resistance,corrosion resistance,high-temperature tolerance,and burning resistance.Owing to the rarity of the small/negative SE in inorganic materials,the concept to reduce SE byθ-Al_(2)O_(3) may foster a blowout to develop robust superhydrophobicity by complete inorganic materials. | Zhongzhen Wu Liangliang Liu Shunning Li Shunping Ji Pinghu Chen Suihan Cui Zhengyong Ma Yuchang Weng Qian Huang Zhongcan Wu Hao Wu Yuan Lin Ricky KYFu Hai Lin Xiubo Tian Paul KChu Feng Pan | 2019 | Research2019，，1： | 6 |
| 11 | 高压耦合高功率脉冲磁控溅射的增强放电效应显示文摘等离子体源离子注入与沉积技术作为一种可生产高结合力、高致密度涂层的真空镀膜技术,具有广阔的应用前景,尤其适用于高载荷工况下服役的功能涂层制备.该技术中金属等离子体源是关键,而现有的脉冲阴极弧源结构复杂,且由于伴随'金属液滴'而需要增加过滤装置.本文研究了另一种简单结构的金属等离子体源备选一高功率脉冲磁控溅射源(HPPMS)的放电特性,采用等离子体发射光谱仪探索了不同的耦合高压对HPPMS放电靶电流特性和等离子体特性的作用.发现耦合高压对HPPMS放电有明显的促进作用,相同靶电压下的放电强度大幅增加,相对于金属放电,耦合高压对气体放电的促进作用更加明显,但在自溅射为主的高压放电阶段对金属放电的促进作用明显增强.讨论了耦合高压对HPPMS放电的增强机制,发现耦合高压自辉光放电、耦合高压和HPPMS电压构成双向负压形成的空心阴极效应,以及耦合高压鞘层改善的双极扩散效应都对HPPMS放电的增强有明显作用. | 吴忠振 田修波 潘锋 Ricky K.Y.Fu 朱剑豪 | 2014 | 物理学报2014，63，18： | 5 |
| 12 | 凹模内腔等离子体离子注入数值仿真—(Ⅰ)脉冲宽度效应显示文摘模具表面改性日益受到人们重视。本文采用二维Particle-in-cell/Monte Carlo Collision模型对等离子体浸没离子注入处理凹模型腔内表面的鞘层动力学及均匀性进行了研究。考察了电压脉宽对鞘层中电势分布、离子的运动状态以及型腔内表面离子注入剂量、能量和角度的空间分布的影响。结果表明随着电压脉宽的增加,凹模型腔内表面的注入剂量不均匀性增加,同时注入到内表面的高能离子数目也增加。脉冲宽度变化对注入角度影响不大,离子以接近垂直的入射角度注入到型腔底部,而在侧壁上离子注入角度接近45°。当脉冲宽度较大时,发现少部分注入到侧壁上的离子以一定角度从下往上注入到样品表面,这是由于碰撞效应造成的。从能量和剂量的角度,存在一个合适的脉冲宽度,过大的脉宽会引起剂量不均匀性增加,同时离子注入能量也会下降。 | 汪志健 田修波 王蓬 巩春志 杨士勤 Ricky Fu | 2010 | 真空科学与技术学报2010，30，6： | 4 |
| 13 | Preparation and investigation of Pd doped Cu catalysts for selective hydrogenation of acetylene显示文摘A series of PdCu bimetallic catalysts with low Cu and Pd loadings and different Cu:Pd atomic ratios were prepared by conventionally sequential impregnation(CSD)and modified sequential impregnation(MSI)of Cu and Pd for selective hydrogenation of acetylene.Characterization indicates that the supported copper(I)nitrate in the PdCu bimetallic catalysts prepared by MSI can be directly reduced to Cu metal particles due to the hydrogen spillover from Pd to Cu(NO3)2 crystals.In addition,for the catalysts prepared by MSI,Pd atoms can form PdCu alloy on the surface of metal particles,however,for the catalysts prepared by CSI,Pd tends to migrate and exist below the surface layer of Cu.Reaction results indicate that compared with CSI,the MSI method enables samples to possess preferable stability as well as comparable reaction activity.This should be due to the MSI method in favor of the formation of PdCu alloy on the surface of metal particles.Moreover,even Pd loading is super low,<0.045 wt-%in this study,by through adjusting Cu loading to an appropriate value,attractive reactivity and selectivity still can be achieved. | Xinxiang Cao Tengteng Lyu Wentao Xie Arash Mirjalili Adelaide Bradicich Ricky Huitema Ben W.-L.Jang Jong K.Keum Karren More Changjun Liu Xiaoliang Yan | 2020 | Frontiers of Chemical Science and Engineering2020，14，4： | 4 |
| 14 | Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion显示文摘Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEC). Recent evidence suggests that LSEC coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI. | Yuri L Boteon Richard Laing Hynek Mergental Gary M Reynolds Darius F Mirza Simon C Afford Ricky H Bhogal | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 15 | 凹模内腔等离子体离子注入数值仿真——(Ⅱ)工作气压的影响显示文摘模具表面改性对提高模具使用寿命和生产率有着十分重要的意义。本文采用二维Particle-in-cell/Monte Carlo colli-sion模型对不同气压下等离子体离子注入处理凹模型腔内表面的鞘层动力学进行研究。考察了气压变化对电势分布、离子运动状态及凹模型腔内表面离子注入剂量、能量和角度分布的影响。计算结果表明随着气压的上升,凹模周围的鞘层厚度变薄;随气压上升,凹模型腔底部和顶部端面离子注入剂量和平均注入能量下降,在型腔侧壁上,离子注入剂量和平均注入能量先上升后下降。注入到型腔侧壁和凹模顶部端面上的离子平均注入角度随气压上升而趋向于垂直入射,型腔底部平均注入角度随气压上升略有增大。研究结果表明通过引入一定的碰撞(变化气压)来改善剂量和能量的均匀性是可行的。 | 汪志健 王蓬 巩春志 杨士勤 田修波 Ricky Fu | 2010 | 真空科学与技术学报2010，30，6： | 4 |
| 16 | NoSQL的模式显示文摘过去一两年,一些用于存储大规模数据的数据存储机制逐渐成形,它们与RDBMS模型相去甚远,被统称为NoSQL。提炼出各种NoSQL方案背后共通的技术原理,有助于更深刻地理解它们对应用程序设计的内在影响。 | Ricky Ho | 2010 | 程序员2010，，1： | 4 |
| 17 | 边缘骨性Ⅲ类错手术与非手术效果的对比分析显示文摘目的:比较边缘骨性Ⅲ类错正颌手术与正畸掩饰治疗(拔牙)后的效果差异。方法:对两组骨性Ⅲ类手术边缘病例治疗前后的X线头颅侧位片进行对比分析,其中手术治疗组12例,单纯正畸组13例,所有病例治疗前ANB角都>-5°。结果:手术组治疗的主要变化是下颌骨前齿槽区的后移及下切牙的直立,正畸组的主要变化是下切牙的后倾及后移。两组治疗后的X线头影测量值经Mann-Whitney U检验显示ANB角,上下颌骨长度比(M/M ratio),NAPog角,下切牙倾斜角(∠L1/ML),上下切牙交角(∠U1/L1)有显著性差异,而标志软组织凹陷度的Holdaway角和Z角没有差异。结论:对于骨性Ⅲ类手术边缘错而言,选择合适的病例,手术与正畸掩饰治疗都可以获得可接受的咬合和美观效果。 | 辜岷 A-Bakr M.Rabie Ricky W.K.Wong | 2009 | 口腔医学研究2009，25，5： | 4 |
| 18 | 方管内表面等离子体离子注入动力学GPU-PIC仿真显示文摘内表面改性近年日益受到人们重视。本文采用基于Graphic Processing Unit(GPU)的Particle-in-cell(PIC)模型对方形管内表面的离子注入动力学过程进行数值仿真研究。结果表明在注入过程中,辅助地电极周围形成离子空穴,随时间延长,离子空穴发生交联并不断扩展,直至所有离子注入到方管内壁。离子空穴的形成和扩展使得在管内部形成离子密度波,密度波的传播速度随时间增加。由于等离子体鞘层的不均匀重叠使得管内的初始鞘层厚度分布不均,其中位于拐角附近的鞘层较厚,从而又导致了方管内壁周向上的注入剂量和能量分布存在不均匀性,内壁平面附近位置的注入剂量和注入能量均相对较大,而拐角附近的离子注入剂量和能量最小。本文采用GPU加速PIC的算法取得了高达90的加速比,极大缩短了等离子体粒子模拟的计算时间。 | 汪志健 田修波 巩春志 杨士勤 Ricky Fu | 2011 | 真空科学与技术学报2011，31，4： | 3 |
| 19 | 等离子体浸没离子注入绝缘材料的研究显示文摘等离子体浸没离子注入是一种新形式的离子注入技术,是利用负偏压工件周围形成的等离子体鞘层进行离子加速、进而获得离子注入。等离子体注入的前提条件是工件导电,因此对于绝缘材料的等离子体注入可能存在问题。本文从理论和实际处理的角度论证了绝缘材料等离子体注入的可能性、可操作性,并给出了一些实际例证。 | 田修波 杨士勤 Ricky K Y Fu Paul K Chu | 2006 | 核技术2006，29，5： | 3 |
| 20 | Intelligent resource allocation in mobile blockchain for privacy and security transactions:a deep reinforcement learning based approach显示文摘In order to protect the privacy and data security of mobile devices during the transactions in the industrial Internet of Things(IIoT),we propose a mobile edge computing(MEC)-based mobile blockchain framework by considering the limited bandwidth and computing power of small base stations(SBSs).First,we formulate a joint bandwidth and computing resource allocation problem to maximize the long-term utility of all mobile devices,and take into account the mobility of devices as well as the blockchain throughput.We decompose the formulated problem into two subproblems to decrease the dimension of action space.Then,we propose a deep reinforcement learning additional particle swarm optimization(DRPO)algorithm to solve the two subproblems,in which a particle swarm optimization algorithm is leveraged to avoid the unnecessary search of a deep deterministic policy gradient approach.Simulation results demonstrate the effectiveness of our method from various aspects. | Zhaolong NING Shouming SUN Xiaojie WANG Lei GUO Guoyin WANG Xinbo GAO Ricky YKKWOK | 2021 | Science China(Information Sciences)2021，64，6： | 3 |
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