5篇
您的检索式：作者名="Rezende AS"
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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Neck lymph node metastases to the posterior triangle apex:evaluation of clinical and histopathological risk factors显示文摘 | Chone CT Crespo AN Rezende AS | 2000 | Head Neck2000，22，6： | 1 |
| 3 | Effects of systemic administration of ciliary neurotrophie factor on Bax and Bcl-2 proteins in the lumbar spinal cord of neonatal rats after sciatic nerve transection 显示文摘 | Rezende AC Vieira AS Rogdrio F | 2008 | Braz J Med Biol Res2008，41，11： | 1 |
| 4 | Effects of systemic administration of ciliary neurotrophic factor on Bax and Bcl-2 proteins in the lumbar spinal cord of neonatal rats after sciatic nerve transection 显示文摘 | Rezende AC Vieira AS Rogerio F | 2008 | Braz J Med Biol Res2008，41，11： | 1 |
| 5 | Occurrence of compli-cations and survival rates in elderly with neurological disor- ders undergoing enteral nutrition therapy显示文摘 | Martins AS Rezende NA Torres HO | 2012 | Rev Assoc Med Bras2012，58，6： | 1 |
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