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| 1 | Current status and perspectives of immune-based therapiesfor hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is a frequent cancer with a high mortality.For early stage cancer there are potentially curative treatments including local ablation,resection and liver transplantation.However,for more advanced stage disease,there is no optimal treatment available.Even in the case of a'curative'treatment,recurrence or development of a new cancer in the precancerous liver is common.Thus,there is an urgent need for novel and effective(adjuvant)therapies to treat HCC and to prevent recurrence after local treatment in patients with HCC.The unique immune response in the liver favors tolerance,which remains a genuine challenge for conventional immunotherapy in patients with HCC.However,even in this'immunotolerant'organ,spontaneous immune responses against tumor antigens have been detected,although they are insufficient to achieve significant tumor death.Local ablation therapy leads to immunogenic tumor cell death by inducing the release of massive amounts of antigens,which enhances spontaneous immune response.New immune therapies such as dendritic cell vaccination and immune checkpoint inhibition are under investigation.Immunotherapy for cancer has made huge progress in the last few years and clinical trials examining the use of immunotherapy to treat hepatocellular carcinoma have shown some success.In this review,we discuss the current status of and offer some perspectives on immunotherapy for hepatocellular carcinoma,which could change disease progression in the near future. | Maridi Aerts DaphnéBenteyn Hans Van Vlierberghe Kris Thielemans Hendrik Reynaert | 2016 | World Journal of Gastroenterology2016，22，1： | 24 |
| 2 | SU8 etch mask for patterning PDMS and its application to flexible fluidic microactuators显示文摘Over the past few decades,polydimethylsiloxane(PDMS)has become the material of choice for a variety of microsystem applications,including microfluidics,imprint lithography,and soft microrobotics.For most of these applications,PDMS is processed by replication molding;however,new applications would greatly benefit from the ability to pattern PDMS films using lithography and etching.Metal hardmasks,in conjunction with reactive ion etching(RIE),have been reported as a method for patterning PDMS;however,this approach suffers from a high surface roughness because of metal redeposition and limited etch thickness due to poor etch selectivity.We found that a combination of LOR and SU8 photoresists enables the patterning of thick PDMS layers by RIE without redeposition problems.We demonstrate the ability to etch 1.5-μm pillars in PDMS with a selectivity of 3.4.Furthermore,we use this process to lithographically process flexible fluidic microactuators without any manual transfer or cutting step.The actuator achieves a bidirectional rotation of 50°at a pressure of 200 kPa.This process provides a unique opportunity to scale down these actuators as well as other PDMS-based devices. | Benjamin Gorissen Chris Van Hoof Dominiek Reynaerts Michael De Volder | 2016 | Microsystems & Nanoengineering2016，2，1： | 3 |
| 3 | Quorum signal mol ecules as biosurfactants affecting swarming in Rhizobium etli 显示文摘 | Daniels R Reynaert S Hoekstra H | 2006 | PNAS2006，103，14： | 1 |
| 4 | Expression of somatostatin receptors in normal and cirrhotic human liver and in hepatocellular carcinoma 显示文摘 | Reynaert H Rombouts K Vandermonde A | 2004 | Gut2004，53，8： | 1 |
| 5 | Somatostatin sup- presses endothelin-l-induced rat hepatic steUate cell con- traction via somatostatin receptor subtype 1 显示文摘 | Reynaert H Vaeyens F Qin H | 2001 | Gastroen- terology2001，121，： | 1 |
| 6 | Engineered genes for fertility control and their application in hybrid seed production 显示文摘 | Reynaerts A De Sutter G | 1993 | Scientia Horticultuae1993，55，2： | 1 |
| 7 | Regulation of sinusoidal perfusion in portal hypertension 显示文摘 | Reynaert H Urbain D Geerts A | 2008 | Anat Ree ( Hoboken )2008，291，6： | 1 |
| 8 | American option pricing with imprecise risk-neutral probabilities 显示文摘 | Muzzioli S Reynaerts H | 2007 | International Journal of Approximate Reasoning2007，10，： | 1 |
| 9 | The quantitative measure- ment of DNA hybridization from renaturation rates 显示文摘 | De Ley J Cattoir H Reynaerts A | 1970 | Euro- pean Journal of Biochemistry1970，12，1： | 1 |
| 10 | Systemic and local inflammation in asthma and chronic obstructive pulmonary disease:is there a connection显示文摘 | Wouters EF Reynaert NL Dentener MA Vemooy JH | | 0，，： | 1 |
| 11 | Assembly of microsystems显示文摘 | VAN BRUSSEL H PEIRS J REYNAERTS D | 2000 | Annals of the CIRP2000，49，2： | 1 |
| 12 | Development of an axial microturbine for a portable gas turbine generator 显示文摘 | PEIRS J REYNAERTS D VERPLAETSEN F A | 2003 | J Micromechanics and Microen-gineering2003，13，： | 1 |
| 13 | Design aspects of shape memory actuators显示文摘 | Reynaerts D | 2000 | Mechatronics2000，，8： | 1 |
| 14 | Hepatic stellate cells:role in microcirculation and pathophysiology of portal hypertension显示文摘 | Reynaert H Thompson M G Thomas T | 2002 | Gut2002，50，4： | 1 |
| 15 | Regulation of sinusoidal perfusion in portal hypertension显示文摘 | Reynaert H Urbain D Geerts A | | 0，，： | 1 |
| 16 | Current thempertie strategiea in severe acute pancreatitis显示文摘 | Reynaert MS Dugemier TH Kestens PJ | 1990 | Intensive care Med1990，16，： | 1 |
| 17 | Hepatic stellate cells:role in microcir-culation and pathophysiology of portal hypertension显示文摘 | Reynaert H Thompson M G Thomas T | 2002 | Gut2002，50，4： | 1 |
| 18 | Three dimensional silicon microcomponents manufactured by micro electro discharge machining显示文摘 | Reynaerts Dominiek Brussel Hendrik Van | | SPIE0，3224，： | 1 |
| 19 | Hepatic stellate cells:role in microcirculation and pathophysiology of portal hypertension显示文摘 | Reynaert H Thompson MG Thomas T | | 0，，： | 1 |
| 20 | Novel approach for the Monte Carlo calculation of free-air chamber correction factors 显示文摘 | Mainegra-Hing E Reynaert N Kawrakow I | 2008 | Medical Physics2008，35，8： | 1 |
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