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| 1 | Transcriptional cofactors Ski and SnoN are major regulatorsof the TGF-β/Smad signaling pathway in health and disease显示文摘The transforming growth factor-β(TGF-β)family plays major pleiotropic roles by regulating many physiological processes in development and tissue homeostasis.The TGF-βsignaling pathway outcome relies on the control of the spatial and temporal expression of>500 genes,which depend on the functions of the Smad protein along with those of diverse modulators of this signaling pathway,such as transcriptional factors and cofactors.Ski(Sloan-Kettering Institute)and SnoN(Ski novel)are Smadinteracting proteins that negatively regulate the TGF-βsignaling pathway by disrupting the formation of R-Smad/Smad4 complexes,as well as by inhibiting Smad association with the p300/CBP coactivators.The Ski and SnoN transcriptional cofactors recruit diverse corepressors and histone deacetylases to repress gene transcription.The TGF-β/Smad pathway and coregulators Ski and SnoN clearly regulate each other through several positive and negative feedback mechanisms.Thus,these cross-regulatory processes finely modify the TGF-βsignaling outcome as they control the magnitude and duration of the TGF-βsignals.As a result,any alteration in these regulatory mechanisms may lead to disease development.Therefore,the design of targeted therapies to exert tight control of the levels of negative modulators of the TGF-βpathway,such as Ski and SnoN,is critical to restore cell homeostasis under the specific pathological conditions in which these cofactors are deregulated,such as fibrosis and cancer. | Angeles C.Tecalco-Cruz Diana G.Rios-Lopez Genaro Vazquez-Victorio Reyna E.Rosales-Alvarez Marina Macias-Silva | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 9 |
| 2 | Bioorthogonal chemistry:a covalent strategy for the study of biological systems显示文摘The development of genetically encoded,wavelength-tunable fluorescent proteins has provided a powerful imaging tool to the study of protein dynamics and functions in cellular and organismal biology.However,many biological functions are not directly encoded in the protein primary sequence,e.g.,dynamic regulation afforded by protein posttranslational modifications such as phosphorylation.To meet this challenge,an emerging field of bioorthogonal chemistry has promised to offer a versatile strategy to selectively label a biomolecule of interest and track their dynamic regulations in its native habitat.This strategy has been successfully applied to the studies of all classes of biomolecules in living systems,including proteins,nucleic acids,carbohydrates,and lipids.Whereas the incorporation of a bioorthogonal reporter site-selectively into a biomolecule through either genetic or metabolic approaches has been well established,the development of bioorthogonal reactions that allow fast ligation of exogenous chemical probes with the bioorthogonal reporter in living systems remains in its early stage.Here,we review the recent development of bioorthogonal reactions and their applications in various biological systems,with a detailed discussion about our own work―the development of the tetrazole-based,photoinducible 1,3-dipolar cycloaddition reaction. | LIM Reyna K.V. | 2010 | Science China Chemistry2010，53，1： | 2 |
| 3 | Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction显示文摘In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases.However,it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state.Here,we describe a versatile in vivo gene knock-in methodology that enables the targeting of a broad range of mutations and cell types through the insertion of a minigene at an intron of the target gene locus using an intracellularly linearized single homology arm donor.As a proof-of-concept,we focused on a mouse model of prematureaging caused by a dominant point mutation,which is difficult to repair using existing in vivo genome-editing tools.Systemic treatment using our new method ameliorated aging-associated phenotypes and extended animal lifespan,thus highlighting the potential of this methodology for a broad range of in vivo genome-editing applications. | Keiichiro Suzuki Mako Yamamoto Reyna Hernandez-Benitez Zhe Li Christopher Wei Rupa Devi Soligalla Emi Aizawa Fumiyuki Hatanaka Masakazu Kurita Pradeep Reddy Alejandro Ocampo Tomoaki Hishida Masahiro Sakurai Amy NNemeth Estrella Nunez Delicado Josep MCampistol Pierre Magistretti Pedro Guillen Concepcion Rodriguez Esteban Jianhui Gong Yilin Yuan Ying Gu Guang-Hui Liu Carlos Lopez-Otin Jun Wu Kun Zhang Juan Carlos Izpisua Belmonte | 2019 | Cell Research2019，29，10： | 2 |
| 4 | αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model显示文摘Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular organisms.Their regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with age.During aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016). | Paloma Martinez-Redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto Masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang Maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol Isabel Guillen-Vicente Elena Rodriguez-Inigo Juan Manuel Lopez-Alcorocho Marta Guillen-Vicente George Church Pradeep Reddy Pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte | 2020 | Protein & Cell2020，11，3： | 2 |
| 5 | Order-Chaos Transition of Tw o Trapped Ions显示文摘 | Devoe R G Reyna L | 1988 | Physical Review Letters1988，61，： | 1 |
| 6 | The prevalence and features of the polycystic ovary syndrome in an unselected population 显示文摘 | Azziz R Woods KS Reyna R | 2004 | J Clin Endocrinol Metab2004，89，6： | 1 |
| 7 | The different faces of shared autoimmunity显示文摘 | Rodrtguez - Reyna TS Alarern - Segovia D | 2006 | Autoimmun Rev2006，5，2： | 1 |
| 8 | The prevalence and features of the polycystic ovary syndrome in an unselected population 显示文摘 | Azziz R Woods KS Reyna R | 2004 | J Clin Endocrinol Metab2004，89，6： | 1 |
| 9 | Developmental Reversals in False Memory: Effects of Emotional Valence and Arousal显示文摘 | Brainerd C J Holliday R E Reyna V F | 2010 | Journal of Experimental Child Psychology2010，107，2： | 1 |
| 10 | The prevalence andfeatures of the polycystic ovaiy syndrome in an unselectedpopulation显示文摘 | Azziz R Woods KS Reyna R | 2004 | J Clin Endocrinol MeTab2004，89，6： | 1 |
| 11 | Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects显示文摘 | Reyna SM Ghosh S Tantiwong P | | 0，，10： | 1 |
| 12 | Fuzzy processing in transitivity development显示文摘 | Valerie F. Reyna Charles J. Brainerd | 1990 | Annals of Operations Research1990，，1： | 1 |
| 13 | Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection显示文摘 | Reyna N S Yang Y | | 0，，： | 1 |
| 14 | Cost and Utilization Impact of a Clinical Pathway for Patients Undergoing Pancreaticoduodenectomy显示文摘 | Geoffrey A. Porter MD Peter W. T. Pisters MD Carol Mansyur MA Annette Bisanz MPH Kim Reyna MBA Pam Stanford RN Jeffrey E. Lee MD Douglas B. Evans MD | 2000 | Annals of Surgical Oncology2000，，7： | 1 |
| 15 | Transforming growth factor- stimulates L- Arginine Transport and Metabolism in vascular smooth Muscle cells:Role in polyamine and collagen synthesis显示文摘 | Liao L Reynas Y | 2001 | Circulation2001，103，8： | 1 |
| 16 | Two different water shutoff applications in a poorly consolidated sandstone reservoir with strong waterdrive显示文摘 | Prado M Paleneia J Reyna M | 2005 | SPE 93060--MS2005，，： | 1 |
| 17 | Severe cutaneous reaction to photodynamic therapy with blue light显示文摘 | Moore MM Reyna C Hope RH | | 0，，09： | 1 |
| 18 | A descriptive study of bottle-feeding opportuni ties in preterm infants显示文摘 | Pickler RH Reyna BA | 2003 | Adv Neonatal Care2003，3，3： | 1 |
| 19 | Ertapenem versus ceftriaxone followed by appropriate oral therapy for treatment of complicated urinary tract infections in adults: results of a prospective, randomized, double-blind multicenter study 显示文摘 | Burdmann EA Reyna OG | 2002 | Antimicrob Agents Chemother2002，46，9： | 1 |
| 20 | Developmental Reversals in False Memory:Now You See Them, Now You Don't! 显示文摘 | Holliday R E Brainerd C J Reyna V F | 2011 | Developmental Psychology2011，47，2： | 1 |
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