| 1 | Area under the curve of methotrexate and creatinine clearance are outcome - determining factors in primary CNS lymphomas显示文摘Although high-dose methotrexate(HD-MTX)is the most effective drug against primary CNS lymphomas(PCNSL),outcome-de-termining variables related to its administration schedule have not been defined.The impact on toxicity and outcome of the area under thecurve(AUC(MTX)),dose intensity(DI(MTX))and infusion rate(IR(MTX))of MTX and plsamatic creatinine clearance(CL(crea))was investigated in a retrospective series of 45 PCNSL patients treated with three different HD-MTX-basedcombinations.Anticon-vulsants were administered in 31 pts(69%).Age>60 years,anticonvulsant therapy,slow IR(MTX)( | FerreriAJ GuerraE RegazziM PasiniF AmbrosettiA PivnikA GubkinA CalderoniA SpinaM BrandesA FerrareseF RognoneA GoviS Dell’OroS LocatelliM VillaE ReniM | 2004 | 中国神经肿瘤杂志2004，2，1： | 9 |
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