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| 1 | Oxidative stress and stress signaling: menace of diabetic cardiomyopathy显示文摘心血管的疾病是在糖尿病的人口的最普通的死因并且当前是在美国和另外的工业化国家的死亡的领先的原因之一。与心血管的疾病联系的护理开销正在蹒跚,到达在 2003 的超过 3500 亿美元。为心血管的疾病的风险因素包括高脂肪 / 胆固醇的层次,酒精中毒,吸烟,遗传,环境因素和高血压,它通常被用来计量一个个人心血管的疾病的风险并且在治疗期间追踪他们的进步。最最近,这些因素在心血管的疾病的早预防变得重要。氧化应力,在由内长的抗氧化剂的反应的氧种类生产和故障之间的不平衡,在象充血心力衰竭和联系糖尿病的心机能障碍(糖尿病的心肌症) 那样的心血管的疾病的发作和前进被含有。抗氧化剂治疗在阻止糖尿病的心复杂并发症的发展显示出诺言。这评论在糖尿病的心肌症在氧化压力理论和抗氧化剂治疗集中于最近的进展,与表明假设被涉及的小径的压力上的一个重音。许多表明小径的这些压力导致反应的氧种类的激活,在糖尿病的心肌症的发展和前进的主要播放器。 | Loren E WOLD Asli F CEYLAN-ISIK Jun REN | 2005 | Acta Pharmacologica Sinica2005，26，8： | 23 |
| 2 | Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology显示文摘AIM: To examine the vitamin D status in patients with alcoholic cirrhosis compared to those with primary biliary cirrhosis. METHODS: Our retrospective case series comprised 89 patients with alcoholic cirrhosis and 34 patients with primary biliary cirrhosis who visited our outpatient clinic in 2005 and underwent a serum vitamin D status assessment. RESULTS: Among the patients with alcoholic cirrhosis, 85% had serum vitamin D levels below 50 nmol/L and 55% had levels below 25 nmol/L, as compared to 60% and 16% of the patients with primary biliary cirrhosis, respectively (P < 0.001). In both groups, serum vitamin D levels decreased with increasing liver disease severity, as determined by the Child-Pugh score. CONCLUSION: Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology, with lower levels of vitamin D in alcoholic cirrhosis than in primary biliary cirrhosis. | Mikkel Malham SΦren Peter JΦrgensen Peter Ott JΦrgen Agnholt Hendrik Vilstrup Mette Borre Jens F Dahlerup | 2011 | World Journal of Gastroenterology2011，17，7： | 15 |
| 3 | bFGF and heparin but not laminin are necessary factors in the mediums that affect NSCs differentiation into cholinergic neurons显示文摘 | Ren W Guo Q Yang Y Chen F | 2006 | 中国生物学文摘2006，20，5： | 10 |
| 4 | Dynamic magnetic resonance defecography in 10 asymptomatic volunteers显示文摘AIM: Evaluation of the wide range of normal findings in asymptomatic women undergoing dynamic magnetic resonance (MR) defecography. METHODS: MR defecography of 10 healthy female volunteers (median age: 31 years) without previous pregnancies or history of surgery were evaluated. The rectum was filled with 180 mL gadolinium ultrasound gel mixture. MR defecography was performed in the supine position. The pelvic floor was visualized with a dynamic T2-weighted sagittal plane where all relevant pelvic floor organs were acquired during defecation. The volunteers were instructed to relax and then to perform straining maneuvers to empty the rectum. The pubococcygeal line (PCGL) was used as the line of reference. The movement of pelvic floor organs was measured as the vertical distance to this reference line. Data were recorded in the resting position as well as during the defecation process with maximal straining. Examinations were performed and evaluated by two experienced abdominal radiologists without knowledge of patient history. RESULTS: Average position of the anorectal junction was located at -5.3 mm at rest and -29.9 mm during straining. The anorectal angle widened significantly from 93° at rest to 109° during defecation. A rectocele was diagnosed in eight out of 10 volunteers showing an average diameter of 25.9 mm. The bladder base was located at a position of +23 mm at rest and descended to -8.1 mm during defecation in relation to the PCGL. The bladder base moved below the PCGL in six out of 10 volunteers, which was formally defined as a cystocele. The uterocervical junction was located at an average level of +43.1 mm at rest and at +7.9 mm during straining. The uterocervical junction of three volunteers fell below the PCGL; described formally as uterocervical prolapse. CONCLUSION: Based on the range of standard values in asymptomatic volunteers, MR defecography values for pathological changes have to be re-evaluated. | Andreas G Schreyer Christian Paetzel Alois Fürst Lena M Dendl Elisabeth Hutzel René Müller-Wille Philipp Wiggermann Stephan Schleder Christian Stroszczynski Patrick Hoffstetter | 2012 | World Journal of Gastroenterology2012，18，46： | 7 |
| 5 | Nomogram for predicting transmural bowel infarction in patients with acute superior mesenteric venous thrombosis显示文摘BACKGROUND The prognosis of acute mesenteric ischemia(AMI)caused by superior mesenteric venous thrombosis(SMVT)remains undetermined and early detection of transmural bowel infarction(TBI)is crucial.The predisposition to develop TBI is of clinical concern,which can lead to fatal sepsis with hemodynamic instability and multi-organ failure.Early resection of necrotic bowel could improve the prognosis of AMI,however,accurate prediction of TBI remains a challenge for clinicians.When determining the eligibility for explorative laparotomy,the underlying risk factors for bowel infarction should be fully evaluated.AIM To develop and externally validate a nomogram for prediction of TBI in patients with acute SMVT.METHODS Consecutive data from 207 acute SMVT patients at the Wuhan Tongji Hospital and 89 patients at the Guangzhou Nanfang Hospital between July 2005 and December 2018 were included in this study.They were grouped as training and external validation cohort.The 207 cases(training cohort)from Tongji Hospital were divided into TBI and reversible intestinal ischemia groups based on the final therapeutic outcomes.Univariate and multivariate logistic regression analyses were conducted to identify independent risk factors for TBI using the training data,and a nomogram was subsequently developed.The performance of the nomogram was evaluated with respect to discrimination,calibration,and clinical usefulness in the training and external validation cohort.RESULTS Univariate and multivariate logistic regression analyses identified the following independent prognostic factors associated with TBI in the training cohort:The decreased bowel wall enhancement(OR=6.37,P<0.001),rebound tenderness(OR=7.14,P<0.001),serum lactate levels>2 mmol/L(OR=3.14,P=0.009)and previous history of deep venous thrombosis(OR=6.37,P<0.001).Incorporating these four factors,the nomogram achieved good calibration in the training set[area under the receiver operator characteristic curve(AUC)0.860;95%CI:0.771-0.925]and the external validation set(AUC 0.851;95%CI:0.796-0.897).The positive and negative predictive values(95%CIs)of the nomogram were calculated,resulting in positive predictive values of 54.55%(40.07%-68.29%)and 53.85%(43.66%-63.72%)and negative predictive values of 93.33%(82.14%-97.71%)and 92.24%(85.91%-95.86%)for the training and validation cohorts,respectively.Based on the nomogram,patients who had a Nomo-score of more than 90 were considered to have high risk for TBI.Decision curve analysis indicated that the nomogram was clinically useful.CONCLUSION The nomogram achieved an optimal prediction of TBI in patients with AMI.Using the model,the risk for an individual patient inclined to TBI can be assessed,thus providing a rational therapeutic choice. | Meng Jiang Chang-Li Li Chun-Qiu Pan Wen-Zhi Lv Yu-Fei Ren Xin-Wu Cui Christoph F Dietrich | 2020 | World Journal of Gastroenterology2020，26，26： | 4 |
| 6 | Role of ultrasound in colorectal diseases显示文摘Ultrasound is an undervalued non-invasive examination in the diagnosis of colonic diseases. It has been replaced by the considerably more expensive magnetic resonance imaging and computed tomography, despite the fact that, as first examination, it can usefully supplement the diagnostic process. Transabdominal ultrasound can provide quick information about bowel status and help in the choice of adequate further examinations and treatment. Ultrasonography,as a screening imaging modality in asymptomatic patients can identify several colonic diseases such as diverticulosis, inflammatory bowel disease or cancer. In addition, it is widely available, cheap, non-invasive technique without the use of ionizing radiation, therefore it is safe to use in childhood or during pregnancy, and can be repeated at any time. New ultrasound techniques such as elastography, contrast enhanced and Doppler ultrasound, miniprobes rectal and transperineal ultrasonography have broadened the indication. It gives an overview of the methodology of various ultrasound examinations, presents the morphology of normal bowel wall and the typical changes in different colonic diseases. We will pay particular attention to rectal and transperineal ultrasound because of their outstanding significance in the diagnosis of rectal and perineal disorders. This article seeks to overview the diagnostic impact and correct indications of bowel ultrasound. | Renáta Bor Anna Fábián Zoltán Szepes | 2016 | World Journal of Gastroenterology2016，22，43： | 4 |
| 7 | Synthesis of large arrays of well-aligned carbon nanotube on glass 显示文摘 | Ren Z F Huang Z P Xu J W | 1998 | Science1998，282，： | 2 |
| 8 | Immunisation against PCV2 structural protein by DNA vaccination of mice显示文摘 | Ren S K Annette M B Tine H F | 2004 | Vaccine2004，22，： | 1 |
| 9 | Sliding wear behavior of copper alloy contact wire against copper-based strip for high-speed electrified railways 显示文摘 | Jia S G Liu P Ren F Z | 2007 | Wear2007，262，78： | 1 |
| 10 | Esophageal imaging and strategies for avoiding injury during left atrial ablation for atrial fibrillation显示文摘 | REN J F LIN D MARCHLINSKI F E | 2006 | Heart Rhythm2006，3，： | 1 |
| 11 | Hemagglutinins in fungus extracts and their blood group specificity显示文摘 | Ren Y Tamiko N | 1996 | Experimental and Clinical Immunogenetics1996，12，4： | 1 |
| 12 | Effect of thermal treatments on third-order nonlinear optical properties of hollow Cu nanoclusters显示文摘 | Wang Y H Jiang C Z Ren F | 2006 | Physica E2006，，33： | 1 |
| 13 | Quantification of rib COL1A2 gene expression in healthy and fluorosed Inner Mongolia cashmere goats显示文摘 | Li W T Yang L F Ren Y C | 2007 | Fluoride2007，40，1： | 1 |
| 14 | A coupled regional air-sea model,its performance and climate drift in simulation of the East Asia summer monsoon in 1998显示文摘 | REN X J QIAN Y F | 2005 | Int J Climatol2005，25，： | 1 |
| 15 | Comprehensive understanding on the formation of highly ordered mesoporous tungsten oxides by X-ray diffraction and Raman spectroscopy显示文摘 | Zhou L Ren Q J Zhou X F | 2008 | Microporous and MesoporousMaterials2008，109，13： | 1 |
| 16 | Vertical vibration of pile in vibration-induced excess pore pressure field显示文摘 | NOGAMI T REN F CHEN J MASON A | 1997 | Journal of Geotechnical and Geoenvironmental Engineering1997，123，5： | 1 |
| 17 | Large piezoelectric effect in Pb-free ceramics显示文摘 | LIU W F REN X B | 2009 | Phys Rev Lett2009，103，25： | 1 |
| 18 | Electrical characteristics of proton-irradiated Sc2O3 passivated AlGaN/GaN high electron mobility transistors显示文摘 | Luo B Jihyun Kim Ren F et al | 2003 | Appl Phys Lett2003，82，93： | 1 |
| 19 | Spectral sensitization of the heterogeneous photocatalytic oxidation of hydroquinone in aqueous solutions at phthalocyanine - coated titanium dioxide powders显示文摘 | Fu - Ren F Fan Allen J Bard | 1979 | J Am Chem Soc1979，101，20： | 1 |
| 20 | Improved morphology for ohmic contacts to AlGaN/GaN high electron mobility transistors using WSix or W-based metallization显示文摘 | LUO B REN F FITCH R C | 2003 | Appl Phys Lett2003，82，22： | 1 |
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