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| 1 | Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan显示文摘AIM: To evaluate the effects of OGG1(Ser326Cys, 11657A/G, and Arg154His) and APE1(Asp148Glu, and T-656G) polymorphisms on colorectal cancer(CRC) risk.METHODS: We enrolled 727 cases newly diagnosed with colorectal adenocarcinoma and 736 age- and sex-matched healthy controls from a medical center in Taiwan. Genomic DNA isolated from the buffy coat was used for genotyping through polymerase chain reaction. Unconditional logistic regressions were used for calculating ORs and 95%CIs to determine the association between the genetic polymorphisms and CRC risk. Haplotype frequencies were estimated using PHASE software. Moreover, stratification analyses onthe basis of sex, age at diagnosis, and tumor subsite and stage were performed.RESULTS: The CRC risk was higher in patients with the OGG1 326Ser/Cys + Cys/Cys genotype(OR = 1.38, 95%CI: 1.03-1.85, P = 0.030), particularly high in patients with stage Ⅲ + Ⅳ cancer(OR = 1.48, 95%CI: 1.03-2.13) compared with patients with the Ser/Ser genotype. In addition, OGG1 11657 G allele carriers had a 41% reduced CRC risk among stage 0-Ⅱ patients(OR = 0.59, 95%CI: 0.35-0.98). The CRC risk was significantly higher among females with the APE1 Glu allele(OR = 1.41, 95%CI: 1.02-1.96). The APE1 148Glu/-656 G haplotype was also associated with a significant CRC risk in females(OR = 1.36, 95%CI: 1.03-1.78).CONCLUSION: OGG1 and APE1 polymorphisms are associated with stage- and sex-specific risk of CRC in the Taiwan Residents population. | Ching-Yu Lai Ling-Ling Hsieh Reiping Tang Regina M Santella Chung Rong Chang-Chieh Chih-Ching Yeh | 2016 | World Journal of Gastroenterology2016，22，12： | 7 |
| 2 | Evaluation of contrast-enhanced computed tomographic colonography in detection of local recurrent colorectal cancer显示文摘瞄准:评估诊断精确性,敏感,在检测颜色的本地复发的提高对比的计算 tomographic colonography 的特性表面的癌症。方法:从 2000 年 1 月到 2004 年 12 月, 434 个病人在以后潜在地药品为侵略颜色的切除术表面的癌症被跟随在上面为从 20 ~ 55 瞬间的经期。为复发显示出充分临床的证据的 434 个病人中的八十个在最后后续期间渲染表面的癌症在这研究被注册。每个病人在一样的天经历了提高对比的计算 tomographic colonography 和结肠镜检查。任何损害,活体检视,在 colonoscopic 期间鉴别检查,立即的复杂并发症和过程的持续时间被记录。提高对比的计算 tomographic colonography 的结果被结肠镜检查,发现的 surgical,和临床的后续比作那些评估。结果:提高对比的计算 tomographic colonography 在检测本地周期性的颜色有 100% , 83% 的特性和 94% 的全面精确性的敏感表面的癌症。结论:常规结肠镜检查和提高对比的 tomographic colonography 能在检测颜色的本地复发补充对方表面的癌症。 | Yau-Tong You Chung-Rong Chang Chien Jeng-Yi Wang Koon-Kwan Ng Jinn-Shiun Chen Reiping Tang Jy-Ming Chiang Chien-Yuh Yeh Pao-Shiu Hsieh | 2006 | World Journal of Gastroenterology2006，12，1： | 7 |
| 3 | Role of body mass index in colon cancer patients in Taiwan显示文摘AIM:To determine the effect of body mass index(BMI) on the characteristics and overall outcome of colon cancer in Taiwan.METHODS:From January 1995 to July 2003,2138 patients with colon cancer were enrolled in this study.BMI categories(in kg/m 2) were established according to the classification of the Department of Health of Taiwan.Postoperative morbidities and mortality,and survival analysis including overall survival(OS),diseasefree survival(DFS),and cancer-specific survival(CSS) were compared across the BMI categories.RESULTS:There were 164(7.7%) underweight(BMI < 18.5 kg/m 2),1109(51.9%) normal-weight(BMI = 18.5-23.9 kg/m 2),550(25.7%) overweight(BMI = 24.0-26.9 kg/m 2),and 315(14.7%) obese(BMI ≥27 kg/m 2) patients.Being female,apparently anemic,hypoalbuminemic,and having body weight loss was more likely among underweight patients than among the other patients(P < 0.001).Underweight patients had higher mortality rate(P = 0.007) and lower OS(P < 0.001) and DFS(P = 0.002) than the other patients.OS and DFS did not differ significantly between normal-weight,overweight,and obese patients,while CSS did not differ significantly with the BMI category.CONCLUSION:In Taiwan,BMI does not significantly affect colon-CSS.Underweight patients had a higher rate of surgical mortality and a worse OS and DFS than the other patients.Obesity does not predict a worse survival. | Chih-Chien Chin Yi-Hung Kuo Chien-Yuh Yeh Jinn-Shiun Chen Reiping Tang Chung-Rong Changchien Jeng-Yi Wang Wen-Shih Huang | 2012 | World Journal of Gastroenterology2012，18，31： | 4 |
| 4 | Vegetable/fruit, smoking, glutathione S-transferase polymorphisms and risk for colorectal cancer in Taiwan显示文摘AIM: To investigate the colorectal cancer risk associated with polymorphic GSTM1, GSTT1 and GSTP1 and the effect of diet and smoking.METHODS: With consents, genotypes of the genes were determined using PCR methods for 727 cases and 736sex and age-matched healthy controls recruited at a medical center in the Northern Taiwan. Nurses who were blind to the study hypothesis conducted interviews with study participants for the information of socio-demographic variables, diet and smoking.RESULTS: There was no significant association between GSTM1 genotypes and the disease. Men, not women, with GSTT1 null genotype were at significant risk of colorectal cancer, but limited to rectal tumor, and in men aged 60 years and less. The corresponding association with the GSTP1 with G allele compared to GSTP1 A/A genotype was at borderline significance. Compared to men with GSTT1 present and GSTP1 A/A combined, men with both GSTT1 null and GSTP1 with G allele genotypes were at significant risk (odds ratio (OR) = 1.91, 95% confidence interval (CI) = 1.21-3.02), also limited to the rectal tumor and younger men. The beneficial effects of vegetable/fruit intake on colorectal cancer were much higher for men with GSTT1 present (OR = 0.32, 95%CI = 0.20-0.50) or GSTP1 A/A genotypes (OR = 0.40, 95%CI = 0.25-0.64).These effects remained significant for women. But, the greatest protective effect from vegetable/fruit intake for women was observed in those with GSTT1 null or GSTP1 with G allele genotypes. In addition, non-smoking men benefitted significantly from combined effect of higher vegetable/fruit intake and GSTT1 present or GSTP1 A/A genotypes with OR = 0.17 and 0.21 respectively.CONCLUSION: This study suggests that the GSTT1 gene can modulate the colorectal cancer risk and vegetable/fruit-related colorectal cancer risk, particularly in men of no smoking history. | Chih-Ching Yeh Ling-Ling Hsieh Reiping Tang Chung Rong Chang-Chieh Fung-Chang Sung | 2005 | World Journal of Gastroenterology2005，11，10： | 4 |
| 5 | Primary colorectal lymphoma显示文摘 | Chung-Wei Fan M.D. Dr. Chung Rong Changchien M.D. Jeng-Yi Wang M.D. Jinn-Shiun Chen M.D. Kuan-Cheng Hsu M.D. Reiping Tang M.D. Jy-Ming Chiang M.D | 2000 | Diseases of the Colon & Rectum2000，，9： | 2 |
| 6 | Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan显示文摘 | Chih-Ching Yeh Fung-Chang Sung Reiping Tang Chung Rong Chang-Chieh Ling-Ling Hsieh | 2007 | Journal of Biomedical Science2007，，2： | 2 |
| 7 | Standards for Internet-Based Experimentiong显示文摘 | Reips U D | 2002 | Experimental Psychology2002，49，4： | 1 |
| 8 | High strength microalloyed CMn ( V - Nb - Ti ) and CMn (V-Nb) pipeline steels processed thrnugh CSP thin- slab technology: microstructure, precipitation and mechanical properties 显示文摘 | REIP C P SHANMUGAM S MISRA R D K | 2006 | Materials Science and Engi- neering: A2006，424，12： | 1 |
| 9 | Risk Factors for Lymph Node Metastasis in pT1 and pT2 Rectal Cancer: A Single-Institute Experience in 943 Patients and Literature Review显示文摘 | Hao-Cheng Chang MD Shih-Chiang Huang MD Jinn-Shiun Chen MD Reiping Tang MD Chung Rong Changchien MD Jy-Ming Chiang MD Chien-Yuh Yeh MD Pao-Shiu Hsieh MD Wen-Sy Tsai MD Hsin-Yuan Hung MD Jeng-Fu You MD | 2012 | Annals of Surgical Oncology2012，，8： | 1 |
| 10 | Clinical significance of signet ring cell rectal carcinoma显示文摘 | Jinn-Shiun Chen Pao-Shiu Hsieh Shin-Yuan Hung Reiping Tang Wen-Sy Tsai Chung-Rong Changchien Paul-Yann Lin Jeng-Yi Wang Chien-Yuh Yeh | 2004 | International Journal of Colorectal Disease2004，，2： | 1 |
| 11 | Favorable Influence of Age on Tumor Characteristics of Sporadic Colorectal Adenocarcinoma显示文摘 | Jy-Ming Chiang M.D. Min-Chi Chen Ph.D. Chung Rong Changchien M.D. Jinn-Shiun Chen M.D. Reiping Tang M.D. Jeng-Yi Wang M.D. Chien-Yuh Yeh M.D. Chung-Wei Fan M.D. Wen-Sy Tsai M.D | 2003 | Diseases of the Colon & Rectum2003，，7： | 1 |
| 12 | Interval - level measurement with visual analogue scales in Internet - based research: VAS Generato 显示文摘 | Reips UD Funke F | 2008 | Behav Res Methods2008，40，7： | 1 |
| 13 | 3-D Simulation of hot forming and microstructure evolution显示文摘 | Grass H Krempaszky C Reip T | | 0，，： | 1 |
| 14 | Interval-level measurement with visual analogue scales in Internet-based research: VAS Generator 显示文摘 | Reips UD Funke F | 2008 | Behav Res Methods2008，40，3： | 1 |
| 15 | Polymorphisms of the XRCC1,XRCC3 and XPD genes, and colorectal cancer risk:a case-control study in Taiwan 显示文摘 | Chih-Ching Yeh Fung-Chang Sung Reiping Tang | 2005 | BMC Cancer2005，5，1： | 1 |
| 16 | High strength microalloyed CMn (V Nb-Ti) and CMn (V-Nb) pipeline steels processed through CSP thin slab technology: mierostructure, precipitation and mechanical properties 显示文摘 | REIP C P SHANMUGAM S MISRA R D K | 2006 | Materials Science and Engineering: A2006，424，12： | 1 |
| 17 | The Web Experimental Psychology Labriive years of data collection on the Internet显示文摘 | Reips U D | 2001 | Behavior Research Meth-ods Instruments & Computers2001，33，2： | 1 |
| 18 | Frequent and rapid emer gence of mutated pre- C sequences in HBV from e-antigen posi rive carriers who seroconvert to anti-HBe during interferon treatment显示文摘 | Gunther S Meisel H Reip A | 1992 | Virology1992，187，27： | 1 |
| 19 | Standards for Internet-based experimenting显示文摘 | Reips U D | 2002 | Experimental Psychology2002，49，： | 1 |
| 20 | Big data: big gaps of knowledge in the field of Internet Science显示文摘 | Snijders C Matzat U Reips U D | 2012 | International Journal of Internet Science2012，7，1： | 1 |
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