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| 1 | Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis显示文摘AIM:To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy.METHODS: An open label multicenter study was carried out in 39 patients with active ulcerative colitis (CAI6-8) despite continuous use of steroids (a minimum total dose of 400 mg prednisone within the last 4 wk).Patients received a total of five aphereses using a granulocyte adsorptive technique (Adacolumn(R), Otsuka Pharmaceutical Europe, UK). Assessments at wk 6 and during follow-up until 4 mo comprised clinical (CAI) and endoscopic (EI) activity index, histology, quality of life(IBDQ), and laboratory tests.RESULTS: Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 (37.1%) patients achieved clinical remission and 10/35 (28.6%) patients had endoscopic remission (CAI<4, EI<4). Quality of life (IBDQ) increased significantly (24 points, P<0.01)at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia.CONCLUSION: In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent. | Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia Morgenstern Joachim M(o|¨)ssner Stephan Schreiber Maurizio Vecchi Alberto Malesci Max Reinshagen Robert L(o|¨)fberg | 2005 | World Journal of Gastroenterology2005，11，44： | 4 |
| 2 | 炎症性肠病治疗策略:逐步升级抑或逐步降阶疗法?显示文摘关于炎症性肠病(IBD)的治疗,国际指南推荐对溃疡性结肠炎(UC)及克罗恩病(CD)患者使用逐步升级(bottom—up)的治疗方法。逐步升级疗法是根据患者病变范围及严重程度,治疗从采用5-氨基水杨酸制剂和(或)布地奈德、或肾上腺糖皮质激素(简称激素)开始,对激素依赖或激素抵抗的慢性-活动性患者下一步应用免疫抑制剂硫唑嘌呤治疗。对免疫抑制剂无效者,则予以生物学制剂肿瘤坏死因子(TNF)-α单克隆抗体(单抗)治疗。 | Reinshagen M 胡品津(译) 陈白莉(译) | 2008 | 中华消化杂志2008，28，12： | 2 |
| 3 | Aktualisierte Leitlinie zur Diagnostik und Therapie der Colitis ulcerosa 2011 – Ergebnisse einer Evidenzbasierten Konsensuskonferenz显示文摘 | A. Dignass J. Prei? D. Aust F. Autschbach A. Ballauff G. Barretton B. Bokemeyer S. Fichtner-Feigl S. Hagel K. Herrlinger G. Jantschek A. Kroesen W. Kruis T. Kucharzik J. Langhorst M. Reinshagen G. Rogler D. Schleiermacher C. Schmidt S. Schreiber H. Schulz | 2011 | Z Gastroenterol2011，，09： | 2 |
| 4 | Nerve growth factor secretion in cultured enteric gila cells is modulated by proinflammatory cytokines 显示文摘 | yon Boyen GB Steinkamp M Reinshagen M | 2006 | J Neuroendocrinol2006，18，11： | 1 |
| 5 | Glial-derived neurotrophic factor regulates apoptosis in colonic epithelial cells显示文摘 | Martin Steinkamp Irmlind Geerling Thomas Seufferlein Georg von Boyen Bernhard Egger Johannes Grossmann Leopold Ludwig Guido Adler Max Reinshagen | 2003 | Gastroenterology2003，，： | 1 |
| 6 | Helium pneumoperitoneum reduces tumor recurrence after curative laparoseopic liver resection in rats in a tumor-bearing small animal model显示文摘 | Sehmedling M Schwalbach P Reinshagen S | 2003 | Surg Endosc2003，17，6： | 1 |
| 7 | Right-versus left-sided congenital diaphragmatic hernia:Postnatal outcome at a specialized tertiary care center显示文摘 | Schaible T Kohl T Reinshagen K | | 0，，01： | 1 |
| 8 | Increased expres sion of epidermal growth factor-receptor in an experimental model of colitis in rats显示文摘 | Reinshagen M Zeeh JM | 2000 | Scand J Gastroenterol2000，35，11： | 1 |
| 9 | Proinflammatory cytokines in- crease glial fibrillary acidic protein expression inenteric glia 显示文摘 | von Boyen GBT Steinkamp M Reinshagen M | 2004 | Gut2004，53，9： | 1 |
| 10 | Helium pneumoperitoneum reduces tumor recurrence after curative laparoscopic liver resection in rats in a tumor-bearing small animal model显示文摘 | Schmeding M Schwalbach P Reinshagen S | 2003 | Surg Endosc2003，17，6： | 1 |
| 11 | MRI of the abdomen with oral contrast agents for the diagnosis of inflammatory Small bowel disease显示文摘 | Nussle K Reinshagen M | 2002 | Abdom Imaging2002，27，4： | 1 |
| 12 | Protective effect of epidermal growth factor in an experimental model of colitis in rats显示文摘 | Reinshagen M Hoffmann P | 1994 | Gastroenterology1994，107，1： | 1 |
| 13 | Nerve Growth Factor and Its High-Affinity Receptor in Chronic Pancreatitis显示文摘 | Helmut Friess Zhao-Wen Zhu Fabio F. di Mola Christoph Kulli Hans U. Graber ?ke Andren-Sandberg Arthur Zimmermann Murray Korc Max Reinshagen Markus W. Büchler | 1999 | Annals of Surgery1999，，5： | 1 |
| 14 | 6-thioguanine nucleo- tide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease:results from a randomized, controlled, open trial 显示文摘 | Reinshagen M Schtitz E Armstrong VW | 2007 | Clin Chem2007，53，7： | 1 |
| 15 | Proinflammatory cytokines increase glial fibrillary acidic protein expression in enteric glia显示文摘 | Von Boyen GB TCSteinkamp M Reinshagen M | 2004 | Gut2004，53，2： | 1 |
| 16 | C alcitonin gene related peptide mediates the protective effect of sensory nerves in a model of colonic injury显示文摘 | Reinshagen M Flamig G Ernst S | 1998 | J Pharmacol Exp Ther1998，286，2： | 1 |
| 17 | Sonographic measurement of thickened bowel wall segments as a quantitativeparameter for activity in inflammatory bowel disease.显示文摘 | D. Mayer M. Reinshagen R. Mason R. Muche C. von Tirpitz D. Eckelt G. Adler K. Beckh W. Kratzer | 2000 | Z Gastroenterol2000，，04： | 1 |
| 18 | Lactose intolerance in active Crohn's disease : clinical value of duodenal lactase analysis 显示文摘 | von Tirpitz C Adler G Reinshagen M | 2002 | J Clin Gastroenterol2002，34，1： | 1 |
| 19 | Diagnostic imaging in Crohn’s disease: comparison of magnetic resonance imaging and conventional imaging methods显示文摘 | A. Rieber D. Wruk S. Potthast K. Nüssle M. Reinshagen G. Adler H.-J. Brambs | 2000 | International Journal of Colorectal Disease2000，，3： | 1 |
| 20 | S3-Leitlinie ?Diagnostik und Therapie des Morbus Crohn”显示文摘 | J Hoffmann J Prei? F Autschbach H Buhr W H?user K Herrlinger W H?hne S Koletzko C Krieglstein W Kruis H Matthes G Moser M Reinshagen G Rogler S Schreiber A Schreyer B Sido B Siegmund A Stallmach B Bokemeyer E Stange M Zeitz | 2008 | Z Gastroenterol2008，，09： | 1 |
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