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4篇 您的检索式:作者名="Reinald Fischer"
    题名 作者 年代 出处 被引量
1Genotype-dependent activation or repression of HBV enhancer Ⅱ by transcription factor COUP-TF1显示文摘AIM: To study the expression of HBV enhancer Ⅱ by transcription factor COUP-TF1. METHODS: In order to study the regulation of HBV variants in the vicinity of the NRRE we cloned luciferase constructs containing the HBV enhancer Ⅱ from variants and from HBV genotypes A and D and cotransfected them together with expression vectors for COUP-TF1 into HepG2 cells. RESULTS: Our fi ndings show that enhancer Ⅱ of HBV genotype A is also repressed by COUP-TF1. In contrast, two different enhancer Ⅱ constructs of HBV genotype D were activated by COUP-TF1. The activation was independent of the NRRE because a natural variant with a deletion of nt 1763-1770 was still activated by COUP- TF1. CONCLUSION: Regulation of transcription of the HBV genome seems to differ among HBV genomes derived from different genotypes. These differences in transcriptional control among HBV genotypes may be the molecular basis for differences in the clinical course among HBV genotypes.Silke F Fischer Katja Schmidt Nicola Fiedler Dieter Glebe Christian Schüttler Jianguang Sun Wolfram H Gerlich Reinald Repp Stephan Schaefer 2006World Journal of Gastroenterology2006,12,37:2
2A new set of nickelacyclic carboxylates ('nickelalactones') containing pyridine as supporting ligand:Synthesis,structures and application in C-C and C-S linkage reactions显示文摘Jens Langer Reinald Fischer Helmar G(o)rls 2004Journal of Organometallic Chemistry2004,689,:1
3A key step in the formation of acrylic acid from CO2 and ethylene:The transformation of a nickelalactone into a nickel-acrylate complex显示文摘Reinald Fischer Jens Langer Astrid Malassa 2006Chem Commun2006,,:1
4A new set of nickelacyclic carboxylates ('nickelalactones') containing pyridine as supporting ligand: synthesis, structures and application in C-C- and C-S- linkage reactions 显示文摘Jens Langer Reinald Fischer Helmar G6rls 2004Journal of Organometallic Chemistry2004,689,:1
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