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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes显示文摘 | Reijonen H Mallone R Heninger AK | 2004 | Diabetes2004，53，8： | 1 |
| 3 | Use of HLA class Ⅱ tetramers in tracking antigenspecific T cells and mapping T-cell epitopes 显示文摘 | Reijonen H Kwok WW | 2003 | Methods2003，29，： | 1 |
| 4 | Genetic markers, humoral autoimmunity, and predliction of type 1 diabetes in siblings of affected chidren显示文摘 | Kulmala P Savola K Reijonen H | 2000 | Diabetes2000，49，1： | 1 |
| 5 | Histology of injected autologous fascia in the paralyzed canine vocal fold显示文摘 | REIJONEN P LEIVO L NEVALAINEN T | 2001 | Laryngoscope2001，111，： | 1 |
| 6 | Allergen-specific immunogiobulin E antibodies in wheezing infants: the risk for asthma in later childhood显示文摘 | Kotaniemi - Syrjanen A Reijonen TM Romppanen J | 2003 | Pediatrics2003，111，3： | 1 |
| 7 | Genetic markers, humoral autoimmunity, and prediction of type 1 diabetes in siblings of affected显示文摘 | Kulmala P Savola K Reijonen H | 2000 | Diabetes2000，49，： | 1 |
| 8 | Rhinovirus-induced wheezing in infancy--the first sign of childhood asthma显示文摘 | Kotaniemi-Syrjanen A Vainionpaa R Reijonen TM | 2003 | J Allergy Clin Immunol2003，111，1： | 1 |
| 9 | Rhinovirus-induced wheezing in infancy-the first sign of childhood asthma显示文摘 | Kotaniemi-Syrjanen A Vainionpaa R Reijonen TM | 2003 | J Allergy Clin Immunol2003，111，1： | 1 |
| 10 | Compact neutron source development ant LBNL显示文摘 | Tak Pui Lou Bryan Tolmachoff | 2002 | Applied Radiation and Isotopes2002，，： | 1 |
| 11 | Predictors of asthma three years after hospital admission for wheezing in infancy显示文摘 | Reijonen TM Kotaniemi-Syrj(a)nen A Korhonen K | 2000 | Pediatrics2000，106，6： | 1 |
| 12 | Perceptions of success and its effect on small firm performance显示文摘 | Reijonen H and Komppula R | 2007 | Journal of Small Business and Enterprise Development2007，14，4： | 1 |
| 13 | Recurrence of autoimmunity in pancreas transplant patients:research update显示文摘 | Pugliese A Reijonen HK Nepom J Burke GW 3rd | | 0，，： | 1 |
| 14 | Inhibition of endo-plasmic reticulum stress counteracts neuronal cell death and pro-tein aggregation caused by N-terminal mutant huntingtin proteins显示文摘 | Reijonen S Putkonen N N rrem lle A | 2008 | Exp Cell Res2008，314，5： | 1 |
| 15 | Neutron generators developed at LBNL for homeland security and imaging applications显示文摘 | Reijonen J | 2007 | Nuclear Instruments and Methods in Physics Research B2007，261，： | 1 |
| 16 | Detection of GAD65-specific T-cells by major histocompatibility complex class Ⅱ tetramers in type 1 diabetic patients and at-risk subjects显示文摘 | Reijonen H Novak E J Kochik S Heninger A Liu AW Kwok WW | | 0，，： | 1 |
| 17 | Anti-inflammatory therapy reduces wheezing after bronchiolitis显示文摘 | Reijonen T Korppi M Kuikka L | 1996 | Arch Pediatr Adolesc Med1996，150，： | 1 |
| 18 | Histology of injection autologous fascia in the paralyzed vocal fold显示文摘 | Reijonen P Leivo L Nevalainen T | 2001 | Laryngoscope2001，111，： | 1 |
| 19 | Rhinovirusin- duced wheezing in infancy-the first sign of childhood asthma 显示文摘 | Kotaniemi-Syrjanen A Vainionpaa R Reijonen TM | 2003 | J Allergy Clin Immuno12003，111，1： | 1 |
| 20 | D-D neutron generator development at LBNL显示文摘 | REIJONEN J GICQUEL F HAHTO S K | 2005 | Applied Radiation and Isotopes2005，63，： | 1 |
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