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| 1 | A long-form α-neurotoxin from cobra venom produces potent opioid-independent analgesia显示文摘Aim:In light of the antinociceptive activity of the short-chain neurotoxin,cobrotoxin,and other acetylcholine antagonists,the antinociceptive activity andmechanisms of cobratoxin(CTX),a long-chain postsynaptic α-neurotoxin,wasinvestigated in rodent pain models.Methods:CTX was administered intraperito-neally(30,45,68 μg/kg),intra-cerebral ventricularly(4.5 μg/kg)or microinjectedinto periaqueductal gray(PAG;4.5 μg/kg).The antinociceptive action was testedusing the hot-plate and acetic acid writhing tests m mice and rats.The involve-ment of the cholinergic system and opioid system in CTX-induced analgesia wasexamined by pretreatment of animals with atropine(0.5 mg/kg,im;or 10 mg/kg,ip)or naloxone(1 and 5 mg/kg,ip).The effect of CTX on motor activity was testedusing the Animex test.Results:CTX exhibited a dose-dependent analgesic ac-tion in mice as determined by both the hot-plate and acetic acid writhing tests.The peak effect of analgesia was seen 3 h after administration.In the mouse aceticacid writhing test,the intra-cerebral ventricular administration of CTX at 4.5 μg/kg(1/12th of a systemic dose)produced marked analgesic effects.Microinjection ofCTX(4.5 μgkg)into the PAG region did not elicit an analgesic action in rats in thehot-plate test.Atropine at 0.5 mg/kg(im)and naloxone at 1 and 5 mg/kg(ip)bothfailed to block the analgesic effects of CTX,but atropine at 10 mg/kg(ip)didantagonize the analgesia mediated by CTX in the mouse acetic acid writhing test.Acetylsalicylic acid(300 mg/kg)did not enhance the analgesic effects of CTX.Atthe highest effective dose of 68 μg/kg the neurotoxin did not change the sponta-neous mobility of mice.Conclusion:CTX has analgesic effects,which are medi-ated in the central nervous system though not through the PAG.The centralcholinergic system but not opioid system appears to be involved in theantinociceptive action of CTX. | Zhi-xin CHEN Hui-ling ZHANG Zhen-lun GU Bo-wen CHEN Rong HAN Paul F REID Laurence N RAYMOND Zheng-hong QIN | 2006 | Acta Pharmacologica Sinica2006，27，4： | 7 |
| 2 | Suppression of complete Freund's adjuvant-induced adjuvant arthritis by cobratoxin显示文摘 | Yan-li LIU Hai-ming LIN Rong ZOU Jun-chao WU Rong HAN Laurence N RAYMOND Paul F REID Zheng-hong QIN | 2009 | Acta Pharmacologica Sinica2009，30，2： | 6 |
| 3 | Involvement of cholinergic system in suppression ot formalin-induced inflammatory pain by cobratoxin显示文摘瞄准: 调查 cobratoxin (CTX ) 的止痛效果,长链的 α从泰国眼镜蛇恶意的神经毒素,在导致福尔马林的煽动性的疼痛的一个老鼠模型。 | Gao-na SHI Yan-li LIU Hai-ming LIN Shi-lin YANG Yu-lin Feng Paul F REID Zheng-hong QIN | 2011 | Acta Pharmacologica Sinica2011，32，10： | 6 |
| 4 | Phase Ⅱ trial of the histone deacetylaseinhibitor pivaloyloxymethyl butyrate (Pivanex AN-9) in advanced non-small cell lung cancer 显示文摘 | REID T VALONE F LIPERA W | 2004 | Lung Can2004，45，3： | 1 |
| 5 | Machine vision-based guidance system for an agricultural small-grain harvester显示文摘 | BensonE R Reid J F Zhang Q | 2003 | Transactions of the ASAE2003，46，4： | 1 |
| 6 | Overvoltage protection of shunt-capacitor banks using MOV arresters显示文摘 | Granaghan M F Reid W E Law S W | 1984 | IEEE Trans on Power Apparatus and System1984，103，8： | 1 |
| 7 | Big data: Distilling meaning from data 显示文摘 | Frankel F Reid R | 2008 | Nature2008，455，7209： | 1 |
| 8 | New therapcutic opportunities in epilepsy: A genetic perspective 显示文摘 | Reid C A Jackson G D Berkovic S F | 2010 | Pharmacol Ther2010，1289，2： | 1 |
| 9 | Neurological evaluation of toxic axonopathies in rats: acrylamide and 2,5-hexanedione显示文摘 | LOPACHIN R M ROSS J F REID M L | 2002 | Neurotoxicology2002，23，1： | 1 |
| 10 | Further study discounts role for singlet oxygen in fungal degradation of lignin model compounds显示文摘 | KIRK T K NAKATSUBO F REID I D | 1983 | Biochemical and Biophysical Research Communications1983，111，1： | 1 |
| 11 | Overvoltage pro-tection of shunt-capacitor banks using MOV arresters显示文摘 | Granaghan M F Reid W E Law S W et a1 | 1984 | IEEETransactions on Power Apparatus and System1984，103，8： | 1 |
| 12 | Mechanisms of human inherited epilepsies 显示文摘 | Reid C A Berkovic S F Petrou S | 2009 | Prog Neurobiol2009，87，1： | 1 |
| 13 | Corn kernel breakage classification by machine vision using a neural network classifier显示文摘 | Liao K Paulsen M R Reid J F | 1994 | Transactions of the ASAE1994，36，6： | 1 |
| 14 | Agricultural automatic guidance research in north america 显示文摘 | REID J F ZHANG Q NOGUCHI N | 2000 | Computers and Electronics in Agriculture2000，25，12： | 1 |
| 15 | Stereo vision three-dimensional terrain maps for precision agriculture显示文摘 | Rovira-Mhs F Zhang Q Reid F | 2008 | Computers and Electronics in Agriculture2008，60，2： | 1 |
| 16 | Bacillus thuringiensis-toxin resistance management: Stable isotope assessment o{ alternate host use by Helicoverpa zea 显示文摘 | Gould F Blair N Reid M | 2002 | Proceeding of the National A- cademy of Sciences of the United states of America2002，99，16： | 1 |
| 17 | Corn kernel breakageclassification by machine vision using a neural network classi- fier显示文摘 | Liao K Paulsen M R Reid J F | 1994 | Transactions of the ASAE1994，36，6： | 1 |
| 18 | The use of the splitHopkinson pressure bar techniques in high strain rate mate-rials testing显示文摘 | Al-Mousawi M M Reid S R Deans W F | 1997 | Proceedings of the Institution of MechanicalEngineers Part C:Journal of Mechanical Engineering Sci-ence1997，211，4： | 1 |
| 19 | Patients'perspectives of the doctor patient relationship and information giving across a range of literacy levels 显示文摘 | Shaw A Ibrahim S Reid F | 2009 | Patient Educ Couns2009，75，1： | 1 |
| 20 | Infectivity of a bulgarian and an American strain of Steinernema carpocapsae against codling moth显示文摘 | Vega F E Lacey L A Reid A P | | 0，，： | 1 |
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