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| 1 | 有效的继续医学教育活动:提高医生实践水平改善患者临床疗效显示文摘政府、公众和医疗机构都认为,医疗卫生人员有义务和责任保持自己的医疗水平,提高患者的医疗保健服务质量。美国国家医学研究所(the Institute of Medicine)、美国毕业后医学教育认证委员会(the Accreditation Council for Graduate Medical Education)和美国医学专科委员会(the American Board of Medical Specialties)规定了医疗卫生人员的必备技能,如患者诊疗、医学知识、以实践为基础的学习、改善人际交往和沟通能力、专业性和以系统为基础的实践等。并建议各医学院校的教学课程、医院的住院医师培训项目以及继续医学教育活动都应围绕医疗卫生人员的这些必备技能来设计教学内容。 | Regnier K Kopelow M Lane D Alden E | 2012 | 中国继续医学教育2012，4，2： | 15 |
| 2 | Empirical estimates of regional carbon budgets imply reduced global soil heterotrophic respiration显示文摘Resolving regional carbon budgets is critical for informing land-based mitigation policy.For nine regions covering nearly the whole globe,we collected inventory estimates of carbon-stock changes complemented by satellite estimates of biomass changes where inventory data are missing.The net land–atmospheric carbon exchange(NEE)was calculated by taking the sum of the carbon-stock change and lateral carbon fluxes from crop and wood trade,and riverine-carbon export to the ocean.Summing up NEE from all regions,we obtained a global‘bottom-up'NEE for net land anthropogenic CO_(2)uptake of–2.2±0.6 Pg C yr^(-1)consistent with the independent top-down NEE from the global atmospheric carbon budget during 2000–2009.This estimate is so far the most comprehensive global bottom-up carbon budget accounting,which set up an important milestone for global carbon-cycle studies.By decomposing NEE into component fluxes,we found that global soil heterotrophic respiration amounts to a source of CO_(2)of 39 Pg C yr^(-1)with an interquartile of 33–46 Pg C yr^(-1)—a much smaller portion of net primary productivity than previously reported. | Philippe Ciais Yitong Yao Thomas Gasser Alessandro Baccini Yilong Wang Ronny Lauerwald Shushi Peng Ana Bastos Wei Li Peter A.Raymond Josep G.Canadell Glen P.Peters Rob J.Andres Jinfeng Chang Chao Yue A.Johannes Dolman Vanessa Haverd Jens Hartmann Goulven Laruelle Alexandra G.Konings Anthony W.King Yi Liu Sebastiaan Luyssaert Fabienne Maignan Prabir K.Patra Anna Peregon Pierre Regnier Julia Pongratz Benjamin Poulter Anatoly Shvidenko Riccardo Valentini Rong Wang Grégoire Broquet Yi Yin Jakob Zscheischler Bertrand Guenet Daniel SGoll Ashley-P.Ballantyne Hui Yang Chunjing Qiu Dan Zhu | 2021 | National Science Review2021，8，2： | 3 |
| 3 | 低剂量白细胞介素-2在11种自身免疫疾病中的免疫学和临床疗效:单中心开放临床试验显示文摘背景调节性T(Tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明Treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活Tregs细胞,因此ld-IL2具有广泛的治疗潜力。目的我们通过一项临床试验观察ld-IL2治疗11种自身免疫性疾病中1种的效果,旨在评估ld-IL2的治疗潜力并选择疾病,以用于进一步的临床开发。方法本研究为前瞻开放性Ⅰ~Ⅱa期临床观察,入选了46例轻中度患者,诊断分别为类风湿关节炎、强直性脊柱炎、系统性红斑狼疮、牛皮癣、白塞病、肉芽肿性多血管炎、大动脉炎、克罗恩病、溃疡性结肠炎、自身免疫性肝炎或硬化性胆管炎。所有患者都接受了ld-IL2(100万IU/天)5天,然后每两周注射一次,维持6个月。所有患者均接受了深入的免疫监测和临床评估。结果在任何疾病类型以及任何合并药物治疗的患者中,ld-IL2都显示出了良好的耐受性。通过经典的免疫表型分析和广泛的免疫表型分析发现所有患者的Tregs细胞均被特异性地扩增激活,而效应T细胞没有被活化,提示ld-IL2具有临床疗效的前景。结论本研究中所采用的IL-2剂量和治疗方案可以选择性地激活和扩增Tregs细胞,并且对于不同的疾病种类以及不同的合并用药都是安全的。这一临床疗效以及初步结果可以为ld-IL2在各种自身免疫和自身炎症性疾病中开展Ⅱ期临床试验观察疗效提供了依据。试验注册号NCT01988506. | Michelle Rosenzwajg Roberta Lorenzon Patrice Cacoub Hang Phuong Pham Fabien Pitoiset Karim El Soufi Claire RIbet Claude Bernard Selim Aractingi Beatrice Banneville Laurent Beaugerie Francis Berenbaum Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Arsfene Mekinian Elodie Regnier David Saadoun Joe-Elie Salem Jeremie Sellam Philippe Seksik Anne Daguenel-Nguyen Valene Doppler Jeremie Mariau Eric Vicaut David Klatzmann 杨新蕾(译) 张卓莉(校) | 2019 | 英国医学杂志中文版2019，22，2： | 2 |
| 4 | Evaporation rates of oil components显示文摘 | Regnier Z R Scott B F | 1975 | Environmental Science & Technology1975，9，5： | 1 |
| 5 | Distributed method for inveres kinematies of all serial manipulators 显示文摘 | REGNIER S OUEZDOU F B BIDAUD P | 1997 | Mechanism and Machine Theory1997，32，7： | 1 |
| 6 | Quantitive proteomics strategy involving the selection of peptides containing both cysteine and histidine from tryptic digests of cell lysates显示文摘 | Wang S Zhang X Regnier FJ | 2002 | J Chromatogr A2002，949，： | 1 |
| 7 | Quantitative analysis of an- aerobic oxidation of methane ( AOM ) in marine sediments : A modeling perspective显示文摘 | Regnier P Dale A W Arndt S | 2011 | Earth-Science Reviews2011，106，12： | 1 |
| 8 | Interactions of intergenic microRNAs with mRNAs of genes involved in carcinogenesis 显示文摘 | Issabekova A Berillo O Regnier M | 2012 | Bioinformation2012，8，11： | 1 |
| 9 | Prognostic significance of blood lactate and lactate clearance in trauma patients显示文摘 | Regnier MA Raux M Le MY | 2012 | Anesthesiology2012，117，6： | 1 |
| 10 | Tension de vapeur de l'ethane entre 80 et 135 K显示文摘 | REGNIER J | 1972 | J Chim Phys1972，69，： | 1 |
| 11 | Population pharmacokinetics of marbofloxacin in aqueous humor after intravenous administration in dogs 显示文摘 | REGNIER A CONCORDET D SCHNEIDER M | 2003 | Am J Vet Res2003，64，7： | 1 |
| 12 | Regulation of contraction in striated muscle显示文摘 | GORDON A M HOMSHER E REGNIER M | 2000 | Physiological Reviews2000，80，2： | 1 |
| 13 | Reactivity of Langerhans cells in human reconstructed epidermis to known allergens and UV radiation 显示文摘 | Facy V Flouret V Regnier M | 2005 | Toxicol In Vitro2005，19，： | 1 |
| 14 | Heat-and cold-stress suppresses in vivo and in vitro cellular immune responses of chickens显示文摘 | Regnier J A Kelley K W | 1981 | Am J Vet Res1981，42，2： | 1 |
| 15 | Identification and characterization of an 1KB kinase 显示文摘 | Regnier C H Song H Y Gao X | 1997 | Cell1997，90，： | 1 |
| 16 | Neonalal extracorporeal life support : Impact of new therapies on survival 显示文摘 | Fliman PJ de Regnier RA Kinsella JP | 2006 | J Pediatr2006，148，5： | 1 |
| 17 | Low-dose radiation-induced attenuation at infrared wavelengths for P-doped,Ge-doped and pure silica-core optical fibres显示文摘 | Regnier E Flammer I Girard S | 2007 | IEEE Trans on Nucl Sci2007，54，4： | 1 |
| 18 | The in vitro displacement of adsorbed model antigens from aluminiurn-containing adjuvants by interstitial proteins显示文摘 | Heimlich JM Regnier FE White JL | 1999 | Vaccine1999，17，22： | 1 |
| 19 | Stoichiometric displacement of solvent by nonpolar solutes in reverse-phase liquid chromatography显示文摘 | GENG X D REGNIER F E | 1985 | J Chromatogr1985，332，： | 1 |
| 20 | 显示文摘 | BURKE B J REGNIER F E | 2001 | Electrophoresis2001，22，： | 1 |
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