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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | A method for the determination of nitrification rates in oligotrophicmarine seawater by gas chromatography/mass spectrometry显示文摘 | CLARK D R REES A P JOINT I | 2007 | Mar Chem2007，103，： | 1 |
| 3 | Characterization of polysac- charide structure and interactions by circular dichroism: Order - disorder transition in the calcium alginate system 显示文摘 | Morris E R Rees D A Thom D | 1973 | Journal of the Chemical Society - Chemical Communication1973，7，： | 1 |
| 4 | Filtration increases the correlation between water extractable organic carbon and soil microbial activity显示文摘 | REES R M PARKER J P | 2005 | Soil Biology & Biochemistry2005，37，： | 1 |
| 5 | Cross-reactivity of IgE antibodies to allergens显示文摘 | Aalberse RC Akkerdaas J Van Ree R | 2001 | Allergy2001，56，6： | 1 |
| 6 | Allergy, parasites, and the hygiene hypothesis显示文摘 | Yazdanbakhsh M Kremsner PG van Ree R | 2002 | Science2002，19，： | 1 |
| 7 | Prolonged reductions in placental blood flow and cerebral oxygen delivery in preterm fetal sheep exposed to endotoxin: Possible factors in white matter injury after acute infectioni 显示文摘 | Dalitz P Harding R Rees S | 2003 | J Soc Gynecol Invest2003，10，5： | 1 |
| 8 | Functional magnetic resonance imaging of the human brain: data acquisition and analysis显示文摘 | Turner R Howseman A Rees G E J osephs O Friston K | 1998 | Exp Brain Res1998，123，12： | 1 |
| 9 | Young people and physical activity: a systematic review matching their views to effective interventions 显示文摘 | Rees R Kavanagh J Harden A | 2006 | Health Educ Res2006，21，6： | 1 |
| 10 | The biological basis of injury and neuroprotection in the fetal and neonatal brain 显示文摘 | Rees S Harding R Walker D | 2011 | Int J Dev Neurosci2011，29，6： | 1 |
| 11 | Long-term treatment of intestinal helminths increases mite skin-test reactivity in gabonese schoolchildren显示文摘 | Van den Biggelaar AH Rodrigues LC van Ree R | 2004 | J Infect Dis2004，189，： | 1 |
| 12 | Graphene-based biosensor using transport properties 显示文摘 | Chowdhury R Adhikari S Rees P Wilks S P Scarpa F | 2011 | Physical Review B2011，83，04： | 1 |
| 13 | Extended and compact extragalactic radio sources: interpretation and theory 显示文摘 | Blandford R D Rees M J | 1978 | Physica Scripta1978，17，3： | 1 |
| 14 | Behavioral activation treat- ments for depression in adults : A meta - analysis and review 显示文摘 | Mazzucchelli T G Kane R T Rees C S | 2009 | Clin Psycho12009，16，2： | 1 |
| 15 | Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo显示文摘 | Moncada S Rees DD Schulz R | 1991 | Proc Natl Acad Sci USA1991，88，6： | 1 |
| 16 | Macrofaunal recovery following TBT ban: Long-term recovery of subtidal macrofaunal communities in relation to declining levels of TBT contamination显示文摘 | SMITH R BOLAM S G REES H L | 2008 | Environmental Monitoring and Assessment2008，136，： | 1 |
| 17 | Wheat yield progress associated with higher stomata conductance and photosyn-thetic rate,and cooler canopies显示文摘 | Fischer R A Rees D Sayre K D | 1998 | Crop Science1998，38，6： | 1 |
| 18 | Wheat yield progress associated with higher stomatal conductance and photosynthetic rate,and cooler canopies显示文摘 | Fischer R A Rees D Sayre K D | 1998 | Crop Sci1998，38，： | 1 |
| 19 | Acupuncture of chronic headache disorders in primary care: randomised controlled trial and economic analysis 显示文摘 | Vickers A J Rees RW Zollman CE McCarney R Smith CM Ellis N | 2004 | Health Technol Assess2004，8，48： | 1 |
| 20 | Bcl-2 transgene expression can protect neurons against developmental and induced cell Death显示文摘 | Farlie PG Dringen R Rees SM | 1995 | Proc Natl Acaol Sci USA1995，92，： | 1 |
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