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| 1 | 利拉鲁肽与格列美脲在单药治疗2型糖尿病中的比较(LEAD-3 Mono):一项随机、双盲、平行分组、52周的Ⅲ期临床试验显示文摘背景 2型糖尿病新的治疗策略,需要针对胰岛素-葡萄糖的相互作用,且同时要降低体重增加和发生低血糖的风险。本文作者旨在调查利拉鲁肽单药治疗2型糖尿病的安全性与有效性。
方法 采用双盲、双模拟、治疗一对照、平行分组的研究,746例早期2型糖尿病患者被随机分配到1次/d利拉鲁肽组[1.2mg(n=251)或1.8mg(n=247)]或格列美脲8mg组(n=248),分别治疗52周。主要结局指标为糖化血红蛋白(HbA1c)的改变程度。采用意向性治疗进行分析。该试验在ClinicalTrials.gov网站的注册编码为NTC00294723.
结果52周时,格列美脲组HbA,。下降了0.51%(s=1.20),而利拉鲁肽1.2mg组下降了0.84%(s=1.23)(差值为-0.33.95%CI-0.53~-0.13;P=0.0014),利拉鲁肽1.8mg组下降了1.14%(S=1.24)(差值为-062,95%CI-0.83—-0.42;P〈0.0001)。利拉鲁肽1.2mg组和1.8mg组各有5例和1例患者因呕吐停止治疗,而格列美脲组未出现这种情况。
结论 利拉鲁肽作为2型糖尿病的初始治疗药物安全有效,与格列美脲相比更能降低HbA1c以及体重、血压和低血糖的发生率。 | Alan Garber Robert Henry Robert Rather Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvero-Alvarez Paula M Hale, Milan Zdravkovic Bruce Bode 邓斌(译) | 2009 | 世界临床医学2009，，6： | 5 |
| 2 | Asymptomatic Paget's disease of bone presenting with complete atrioventricular block显示文摘 | A. Rauoof Malik Nazir A. Lone Hilal A. Rather Vicar M Jan Javid A. Malik Khursheed A. Khan S. Jalal | 2008 | Chinese Medical Journal2008，，22： | 3 |
| 3 | C4d staining of perioperative renal transplant biopsies显示文摘 | Haas M Rather LE Montgomery RA | 2002 | Transplantation2002，74，5： | 1 |
| 4 | Electrochemical synthesis of nicotinic acid from 3-picoline显示文摘 | Gupta P N Rather G M | 1988 | J Indian Chem Soc1988，65，9： | 1 |
| 5 | The relationship of urethral caruncle to carcinoma of urethra 显示文摘 | Rather M Schneiderman C | 1948 | Can Med Assoc J1948，58，4： | 1 |
| 6 | Fewer than 12 lymph nodes can be expected in a surgical specimen after high-dose chemoradiation therapy for rectal cancer显示文摘 | M(a)rks JH Valsdottir EB Rather AA | 2010 | Dis Colon Rectum2010，53，7： | 1 |
| 7 | Acuate myocardial infarction in the elderly:Differences by age显示文摘 | Mehta R H Rather S S Radford M J | 2001 | J Am Coll Cardiol2001，38，： | 1 |
| 8 | Electroniv motion in DNA显示文摘 | Rather M | 1999 | Nature1999，397，： | 1 |
| 9 | Electrochemical synthesis of nicotinic acid from β-picoline显示文摘 | Rather G M | 1988 | J Indian Chem Soc,1988，65，9： | 1 |
| 10 | Nodl mediates cytoplasmic sensing of combinations of extracellular bacteria 显示文摘 | Rather AJ Aguilar JL Shchepetov M | 2007 | Cell Microbiol2007，9，5： | 1 |
| 11 | Mixed micellization and interfacial properties of dodecyhrimethylammouium bromide and tetraethy|eneglycol mono - n - dodecyl ether in absence and presence of sodium propiouate显示文摘 | Dar A A Chatterjee B Rather G M | 2006 | J Colloid lntesrace Scl2006，298，1： | 1 |
| 12 | Mixed micelle formation and solubilization behavior toward polycyclic aromatic hydrocarbons of binary and teman: cationic-nonionic surfactant mixtures显示文摘 | Dar A A Rather G M Das A R | 2007 | J Phys Chem B2007，111，12： | 1 |
| 13 | Effect of surfac treat mixing on partitioning of model hydrophobic drug, naproxen, between aqueous and micellar phases显示文摘 | Bhat P A Rather G M Dar A A | 2009 | J Plays Chem B2009，113，： | 1 |
| 14 | Adimission glucose and mortality in eldly patient hospitalized with acute myocardial infarction;implications for patients with and without recognized dia betes显示文摘 | Kosiborod M Rather S S Inzucchi S E | 2005 | Circulation2005，111，： | 1 |
| 15 | Effect of sodium butanoate and sodium hexanoate on micelle formation of modal cationic-notrionic and anionic- nonionic suffactant mixtures显示文摘 | Jan M Dar A A Rather G M | 2009 | Colloids and Surfaces A: Physicochem Eng Aspects2009，335，： | 1 |
| 16 | Design and con- structian of molecular assemblies with large second-or- der optical nonlinearities quantum chemical aspect 显示文摘 | Kanis D R Rather M A Marks T | 1994 | J Chem Rev1994，94，： | 1 |
| 17 | Squamous cell carcinoma显示文摘 | Hawrot A Alam M Rather D | 2003 | Curr Probl Dermatol2003，15，3： | 1 |
| 18 | Molecular rectifiers显示文摘 | Aviram A Rather M A | 1974 | Chem Phys Lett1974，29，： | 1 |
| 19 | 显示文摘 | YALIRAKI S N KEMP M RATHER MARK A | 1999 | J Am Chem Soc1999，121，： | 1 |
| 20 | Direct detection of Bacillus cereus and its enterotoxigenic genes in meat and meat products by polymerase chain reaction 显示文摘 | Rather M A Aulakh R S Gill J P S | 2011 | Journal of Advanced Veterinary Research2011，，1： | 1 |
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