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| 1 | First case report of exacerbated ulcerative colitis after anti-interleukin-6R salvage therapy显示文摘We present the case of a 53-year-old woman with long-standing ulcerative colitis and severe, steroid-dependent disease course unresponsive to treatment with azathioprine, methotrexate, anti-TNF antibodies(infliximab, adalimumab) and tacrolimus, who refused colectomy as a therapeutic option. As the pro-inflammatory cytokine interleukin-6(IL-6) had been identified as a crucial regulator in the immunopathogenesis of inflammatory bowel diseases, we treated the patient with biweekly intravenous infusions of an anti-IL-6R antibody(tocilizumab) for 12 wk. However, no clinical improvement of disease activity was noted. In fact, endoscopic, histological and endomicroscopic assessment demonstrated exacerbation of mucosal inflammation and ulcer formation upon anti-IL-6R therapy. Mechanistic studies revealed that tocilizumab treatment failed to suppress intestinal IL-6 production, impaired epithelial barrier function and induced production of pro-inflammatory cytokines such as TNF, IL-21 and IFN-γ. Inhibition of IL-6 by tocilizumab had no clinical benefit in this patient with intractable ulcerative colitis and even led to exacerbation of mucosal inflammation. Our findings suggest that anti-IL-6R antibody therapy may leadto aggravation of anti-TNF resistant ulcerative colitis. When targeting IL-6, the differential responsiveness of target cells has to be taken into account, as IL-6 on the one side promotes acute and chronic mucosal inflammation via soluble IL-6R signaling but on the other side also strongly contributes to epithelial cell survival via membrane bound IL-6R signaling. | Raja Atreya Ulrike Billmeier Timo Rath Jonas Mudter Michael Vieth Helmut Neumann Markus F Neurath | 2015 | World Journal of Gastroenterology2015，21，45： | 5 |
| 2 | 高速水冷淬火过程中残余压应力的形成显示文摘据文献报道,快速水冷淬火可在试样表面形成残余压应力(RSs)从而显著提高其疲劳极限,这种技术被称为'强烈淬火'。德国热处理协会'淬火'技术委员会发起了一个旨在精确研究上述问题的研究项目。本文重点介绍马氏体相变对残余应力形成的影响。为了在圆柱试样表面得到残余压应力,需要确定合适的工艺窗口。在此窗口中,淬火冷却速度要求足够快,以致于在圆柱体内达到最大温度梯度之前,表面温度已经低于Ms。 | J Rath T Liibben F Hoffmann H-W Zoch 顾剑锋 | 2013 | 热处理2013，28，2： | 3 |
| 3 | Comparison of Hemospray~? and Endoclot? for the treatment of gastrointestinal bleeding显示文摘BACKGROUND Gastrointestinal(GI) bleeding is a common indication for endoscopy. For refractory cases, hemostatic powders(HP) represent 'touch-free' agents.AIM To analyze short term(ST-within 72 h-) and long-term(LT-within 30 d-) success for achieving hemostasis with HP and to directly compare the two agents Hemospray(HS) and Endoclot(EC).METHODS HP was applied in 154 consecutive patients(mean age 67 years) with GI bleeding.Patients were followed up for 1 mo(mean follow-up: 3.2 mo).RESULTS Majority of applications were in upper GI tract(89%) with following bleeding sources: peptic ulcer disease(35%), esophageal varices(7%), tumor bleeding(11.7%), reflux esophagitis(8.7%), diffuse bleeding and erosions(15.3%). Overall ST success was achieved in 125 patients(81%) and LT success in 81 patients(67%). Re-bleeding occurred in 27% of all patients. In 72 patients(47%), HP was applied as a salvage hemostatic therapy, here ST and LT success were 81% and64%, with re-bleeding in 32%. As a primary hemostatic therapy, ST and LT success were 82% and 69%, with re-bleeding occurring in 22%. HS was more frequently applied for upper GI bleeding(P = 0.04)CONCLUSION Both HP allow for effective hemostasis with no differences in ST, LT success and re-bleeding. | Francesco Vitali Andreas Naegel Raja Atreya Steffen Zopf Clemens Neufert Juergen Siebler Markus F Neurath Timo Rath | 2019 | World Journal of Gastroenterology2019，25，13： | 2 |
| 4 | Heterogeneous growth of microcrystalline silicon germanium显示文摘 | Rath Jatindra K Tichelaar F D Schropp Ruud E I | 2002 | Solar Energy Materials & Solar Cells2002，74，14： | 1 |
| 5 | Polarographic determination of nitrate in vegetables显示文摘 | Ximenes M I N Rath S Reyes F G R | 2000 | Talanta2000，51，1： | 1 |
| 6 | Changes in hepatic hemodynamics due to primary liver tumours显示文摘 | Jakab F Rath Z Schmal F | 1996 | HPB Surg1996，9，4： | 1 |
| 7 | Correlation of cellstrain in single osteocytes with intracellular calcium,but not intra-cellular nitric oxide,in response to fluid flow 显示文摘 | RATH A L BONEWALD L F LING J | 2010 | J Biomech2010，43，8： | 1 |
| 8 | Anthocyanin/ polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis显示文摘 | Spormann T M Albert F W Rath T | 2008 | Cancer epidemiology biomarkers & pre- vention2008，17，12： | 1 |
| 9 | Industrial Fluorosis显示文摘 | Franke J Rath F Runge H | 1975 | FLUORIDE1975，8，2： | 1 |
| 10 | Study of the inital stages of drug release from a degradable matrix of poly (d,l--lactide -co-glycolide) 显示文摘 | Frank A Rath S K Boey F | 2004 | Biomaterials2004，25，： | 1 |
| 11 | An investigation of feeding level effects on digestibility in cattle for diets based on grass silage and high fibre concentrates at two forage: concentrate ratios显示文摘 | Mulligan F J Caffrey P J Rath M | 2002 | Livestock Production Science2002，77，23： | 1 |
| 12 | Industrial Fluorosis 显示文摘 | Franke J Rath F Runge H | 1975 | Fluoride1975，8，2： | 1 |
| 13 | Cationic UV cure kinetics for multifunctional epoxies显示文摘 | Boey F Rath S K Ng A K | | 0，，02： | 1 |
| 14 | Kinetic study of thecuring behavior of bismaleimide modified with diallylbi-sphenol A显示文摘 | Xiong Y Boey F Y C Rath S K | 2003 | Journal of Applied Polymer Science2003，，8： | 1 |
| 15 | Kinesins and cancer显示文摘 | Rath O Kozielski F | 2012 | Nat Rev Can- cer2012，12，8： | 1 |
| 16 | Cationic UV cure kinetics for muhifunctional epoxies 显示文摘 | Boey F Rath S K Ng A K | 2002 | Journal of Applied Polymer Science2002，86，2： | 1 |
| 17 | A combined experimental and computer simulation study of HWCVD nip microcrystalline silicon solar cells显示文摘 | Strengers J J H Rubinelli F A Rath J K | 2006 | Thin Solid Films2006，501，： | 1 |
| 18 | Preparation and Structure of New Homochiral Diazaphosphole Ligands and their Platinum( Ⅱ) Chloride Complexes显示文摘 | ASCONCELOS I C F ANDERSON G K RATH N P | 1998 | Tetrahedron:Asymmetry1998，9，： | 1 |
| 19 | Retrograde inspection vs standard forward view for the detection of colorectal adenomas during colonoscopy: A back-to-back randomized clinical trial显示文摘BACKGROUND The adenoma detection rate(ADR)is inversely associated with the incidence of interval colorectal cancer and serves as a benchmark quality criterion during screening colonoscopy.However,adenoma miss rates reach up to 26%and studies have shown that a second inspection of the right colon in retroflected view(RFV)can increase ADR.AIM To assess whether inspection of the whole colon in RFV compared to standard forward view(SFV)can increase ADR.METHODS Patients presenting for screening or surveillance colonoscopy were invited to participate in this randomized controlled trial and randomized into two arms.In RFV arm colonoscopy was initially performed with SFV,followed by a second inspection of the whole colon in RFV.In the SFV arm first withdrawal was performed with SFV,followed by a second inspection of the whole colon again with SFV.Number,size and morphology of polyps found during first and second inspection in each colonic segment were recorded and all polyps were removed and sent for histopathology in separate containers.RESULTS Two hundred and five patients were randomly assigned to the RFV(n=101)and SFV(n=104)arm.In the RFV arm,both polyp detection rate(PDR)and ADR were increased under second inspection in RFV(PDR 1st SFV:39.8%,PDR 2nd RFV:46.6%;ADR 1st SFV:35.2%,ADR 2nd RFV:42%).Likewise,in the SFV arm,PDR and ADR were increased under second inspection(PDR 1st SFV:37.5%,PDR 2nd SFV:46.6%;ADR 1st SFV:34.1%,ADR 2nd SFV:44.3%)with no significant differences in ADR and PDR between the SFV and RFV arm.Mean number of adenomas per patient(APP)was increased in the RFV and SFV(APP RFV arm:1st SFV:1.71;2nd RFV:2.38;APP SFV arm:1st SFV:1.83,2nd SFV:2.2).The majority of adenomas additionally found during second inspection in RFV or in SFV were located in the transverse and left-sided colon and were>5 mm in size.CONCLUSION Second inspection of the whole colon leads to increased adenoma detection with no differences between SFV and RFV.Hence,increased detection is most likely a feature of the second inspection itself but not of the inspection mode. | Timo Rath Lukas Pfeifer Clemens Neufert Andreas Kremer Moritz Leppkes Arthur Hoffman Markus F Neurath Steffen Zopf | 2020 | World Journal of Gastroenterology2020，26，16： | 1 |
| 20 | Tools for developing a quality management program: proactive tools( process mapping, value stream mapping, fault tree analysis, and failure mode and effects analysis )显示文摘 | Rath F | 2008 | Int J Radiat Oncol Biol Phys2008，711，： | 1 |
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