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| 1 | Stem cell-derived exosomes-an emerging tool for myocardial regeneration显示文摘Cardiovascular diseases(CVDs) continue to represent the number one cause of death and disability in industrialized countries. The most severe form of CVD is acute myocardial infarction(AMI), a devastating disease associated with high mortality and disability. In a substantial proportion of patients who survive AMI, loss of functional cardiomyocytes as a result of ischaemic injury leads to ventricular failure, resulting in significant alteration to quality of life and increased mortality. Therefore, many attempts have been made in recent years to identify new tools for the regeneration of functional cardiomyocytes. Regenerative therapy currently represents the ultimate goal for restoring the function of damaged myocardium by stimulating the regeneration of the infarcted tissue or by providing cellsthat can generate new myocardial tissue to replace the damaged tissue. Stem cells(SCs) have been proposed as a viable therapy option in these cases. However, despite the great enthusiasm at the beginning of the SC era, justified by promising initial results, this therapy has failed to demonstrate a significant benefit in large clinical trials. One interesting finding of SC studies is that exosomes released by mesenchymal SCs(MSCs) are able to enhance the viability of cardiomyocytes after ischaemia/reperfusion injury, suggesting that the beneficial effects of MSCs in the recovery of functional myocardium could be related to their capacity to secrete exosomes. Ten years ago, it was discovered that exosomes have the unique property of transferring miRNA between cells, acting as miRNA nanocarriers. Therefore, exosomebased therapy has recently been proposed as an emerging tool for cardiac regeneration as an alternative to SC therapy in the post-infarction period. This review aims to discuss the emerging role of exosomes in developing innovative therapies for cardiac regeneration as well as their potential role as candidate biomarkers or for developing new diagnostic tools. | Erzsebet Lazar Theodora Benedek Szilamer Korodi Nora Rat Jocelyn Lo Imre Benedek | 2018 | World Journal of Stem Cells2018，10，8： | 12 |
| 2 | Effects of Dangshen on isolated gastric muscle strips in rats显示文摘EfectsofDangshenonisolatedgastricmusclestripsinratsZHENGTianZhen1,LIWei1,QUSongYi1,MAYongMing1,DINGYongHui2andWEIYuLing... | ZHENG TianZhen1, LI Wei1, QU SongYi1, MA YongMing1, DING YongHui2 and WEI YuLing2Subject heading Dangshen stomach muscle, smooth muscle contraction receptors, cholinergic rats | 1998 | World Journal of Gastroenterology1998，4，4： | 8 |
| 3 | Intussusception in adults: an unusual and challenging condition for surgeons显示文摘 | Nazif Erkan Mehmet Hac?yanl? Mehmet Y?ld?r?m Hasan Sayhan Enver Vardar Alper F?rat Polat | 2005 | International Journal of Colorectal Disease2005，，5： | 3 |
| 4 | 一种遍及世界的以城市墙壁为画布的原生艺术显示文摘 | Blek Le Rat | 2006 | 美术之友2006，，4： | 2 |
| 5 | Causes cortical brain slices during hypoxia and ischemic: role of ion channels and membrane damage显示文摘 | PHILIP E BICKER M BONN of calcium accumulation in rat C M | 1994 | Brain Res1994，665，2： | 1 |
| 6 | Increased ambulatory arterial stiffness index is associated with target organ damage in primary hypertension显示文摘 | LEONCINI G RAT TO E VIAZZI F | 2006 | Hypertension2006，48，： | 1 |
| 7 | Pa- rameters controlling liquid plasma spraying: solu- tions, sols, or suspensions 显示文摘 | Fauchais P Etchart-Salas R Rat V | 2008 | Journal of Thermal Spray Technology2008，17，1： | 1 |
| 8 | Conformation of tri-and tetra-substituted 2-fluorocyclohexanones:proton non-equivalence F-H and F-C coupling constants,conformational dependence of ^3JFH and ^4JFH显示文摘 | Solladié-Cavallo A Jierry L Bouérat L | 2002 | Tetrahedron2002，58，： | 1 |
| 9 | Phylogenetic analysis of the vertebrate glycoprotein hormone family including new sequences of sturgeon (Acipenser baeri) β subunits of the two gonadotropins and the thyroid-stimulating hormone显示文摘 | Quérat B Sellouk A Salmon C | | 0，，01： | 1 |
| 10 | Phenomena Involved in Suspension Plasma Spraying~ Part i: Suspension Injection and Behavior 显示文摘 | Fazilleau J Delbos C Rat V | 2006 | Plasma Chem Plasma Process2006，26，2： | 1 |
| 11 | Satisfaction with care after total hip or knee replacement predicts self- perceived health status after surgery 显示文摘 | Baumann C Rat AC Osnowycz G | 2009 | BMC Musculoskelet Disord2009，10，： | 1 |
| 12 | Hydrothermal synthesis of zeolite NaX on porous ceramic supports 显示文摘 | Bondareva G V Rat'ko A I Azarov S M | 2003 | Inorganic Materials2003，39，6： | 1 |
| 13 | Living radical polymerization with reversible additional fragmentation chain transfer using dithiocarbonates as chain transfer agents 显示文摘 | MAYADUNNE RAT RIZZARDO E | 1999 | Macromolecules1999，32，： | 1 |
| 14 | Operating parameters for suspension and solution plasma- spray coatings显示文摘 | Fauchais P Rat V Coudert J F | 2008 | Surface and Coatings Technolo- gy2008，202，18： | 1 |
| 15 | Living polymers by the use of trithioearbonates as reversible addition fragmentation chain transfer agents 显示文摘 | MAYADUNNE RAT RIZZARDO E | 2000 | Macromolecules2000，33，： | 1 |
| 16 | Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shea,' resistant T cell arrest, po- larization, and directed crawling on blood-brain barrier endothelium 显示文摘 | Steiner O Coisne C Cecehelli Rat al | 2010 | J lmmunol2010，185，8： | 1 |
| 17 | India’s Commitment to Peaceful Coexistenceand the Settlement of the Indochina War 显示文摘 | Gilles Boque′rat | 2005 | Cold War History2005，5，2： | 1 |
| 18 | Tumorigenic line by human polymorphonuclear leukocytes activated by lipopolysaccharide 显示文摘 | Tamatani T Turk P Weitzman S Oyasu R conversion of a rat urothelial cell | 1999 | Jpn J CancerRes1999，90，8： | 1 |
| 19 | Role of geranylgeranylation and Rho proteins显示文摘 | Essig M Nguyen G Prie D et aL 3-Hydroxy-3-methyl glutaryl coenzyme A reductase inhibittors increase fibrinolytic activity in rat aorticendothelial cell s | 1998 | Circ Res1998，83，7： | 1 |
| 20 | Measurement of matrilin-3 levels in human serum and synovial fluid using a competitive enzyme-linked immunosorbent assay显示文摘 | Vincourt JB Gillet P Rat AC | 2012 | Osteoarthritis & Cartilage2012，20，： | 1 |
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