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| 1 | Characterization of focal liver lesions with SonoVue~-enhanced sonography: International multicenter-study in comparison to CT and MRI显示文摘AIM: To evaluate in a multicenter study whether the sonographic characterization of focal liver lesions can be improved using SonoVueüà-enhancement; and to compare this method with computed tomography (CT) and magnetic resonance imaging (MRI). METHODS: One hundred and thirty four patients with one focal liver lesion detected in baseline ultrasound (US) were examined with conventional US, contrastenhanced US (n = 134), contrast-enhanced CT (n = 115) and/or dynamic contrast-enhanced MRI (n = 70). The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined. The f inal diagnosis based on the combined information of all imaging examinations, clinical information and histology (n = 32) was used. Comparisons were made to see whether the addition of contrast-enhanced US led to the improvement of the characterization of doubtful focal liver lesions. RESULTS: In comparison with unenhanced US, SonoVue markedly improves sensitivity and specificity for the characterization (malignant/benign) of focal liver lesions. In comparison with CT and/or dynamic MRI, SonoVueüà -enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate. In the subgroup with confirmative histology available (n = 30), sensitivity was 95.5% (CEUS), 72.2% (CT) and 81.8% (MRI), and specif icity was 75.0% (CEUS), 37.5% (CT) and 42.9% (MRI). The sensitivity and specif icity of CEUS for the identif ication of focal nodular hyperplasia (FNH) and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%. CONCLUSION: SonoVueüà-enhanced sonography emerges as the most sensitive, most specif ic and thus most accurate imaging modality for the characterization of focal liver lesions. | Hervé Trillaud Jean-Michel Bruel Pierre-Jean Valette Valérie Vilgrain Gérard Schmutz Raymond Oyen Wieslaw Jakubowski Jan Danes Vlastimil Valek Christian Greis | 2009 | World Journal of Gastroenterology2009，15，30： | 34 |
| 2 | 甘草中光甘草定的提取和抗氧化活性研究显示文摘从光果甘草(Glycyrrhiza glabra L.)丙酮提取物中分离得到黄酮类单体成分-光甘草定(Glabridin),并对其抗氧化生物活性进行观察研究。以肝脏微粒体中的细胞色素P450/NADPH氧化系统作为体外抗氧化实验模型。微粒体中自由基诱发程度由探针物DCFH-DA的氧化产物DCF的浓度进行检测。以银杏叶提取物EGB761用作阳性对照物。结果显示,光甘草定以0.10,0.25和0.5 mg/mL浓度,分别抑制自由基浓度67%、73%和83%。在较低浓度时,其抗氧化活性强度与EGB761类似。以上结果说明,光甘草定在细胞色素P450/NADPH氧化系统中具有强抗自由基氧化作用。 | 木合布力.阿布力孜 热娜.卡斯木 马淑燕 Vincent loppinet Gérard siest | 2007 | 天然产物研究与开发2007，19，4： | 27 |
| 3 | 肉苁蓉总苷在HL-60细胞中的抗氧化活性研究显示文摘目的观察肉苁蓉总苷(general cistanosides,GCs)在HL-60细胞中的抗氧化生物活性。方法GCs从新疆盐生肉苁蓉中提取得到;利用HL-60细胞中的氧化系统,对GCs的抗氧化活性进行测定研究。HL-60细胞中自由基诱发程度由探针物DCFH-DA的氧化产物DCF的浓度来检测。银杏叶提取物EGB761用作阳性对照物。结果GCs以0·25、0·50g·L-1和0·75g·L-1浓度,对自由基的抑制率分别为56%、62%和67%。其抗氧化活性与EGB761类似。结论GCs在HL-60细胞氧化系统中具有很强的抗自由基氧化活性。 | 木合布力·阿布力孜 毛新民 热娜·卡斯木 马淑燕 Leininger-Muller B Gérard SIEST | 2008 | 中国药理学通报2008，24，3： | 19 |
| 4 | 菜豆重金属胁迫响应基因:cDNA克隆及其表达分析显示文摘通过差别筛选HgCl2胁迫下的菜豆叶片cDNA库,分离出7组不同的cDNA克隆(Phaseolusvulgarisstress-relatedprotein,PvSR1~7)。cDNA序列和同源性分析结果表明:PvSR1编码富含脯氨酸细胞壁蛋白(PRP),PvSR2和PvSR7编码新的HgCl2胁迫相关蛋白,PvSR3编码脱水蛋白(dehydrin),PvSR4编码病原相关(PR)蛋白,PvSB5编码polyubiqui-tin,PvSR6编码DuaJ-like蛋白。HgCl2胁迫可强烈地请导PvSR2和PR蛋白基因的表达,并能提高PRP,、dehydrinlike和polyubiq-uitin基因的转录水平。这些蛋白质共同作用可能对维持细胞的正常代谢和抵抗重金属胁迫方面有重要作用。 | 柴团耀 张玉秀 G■rard Burkard | 1998 | 植物生理学报(0257-4829)1998，24，4： | 16 |
| 5 | 人肿瘤细胞核苷酸切除修复蛋白表达与抗癌药耐药的相关性(英文)显示文摘背景与目的:核苷酸切除修复(Nucleotideexcisionrepair,NER)是真核细胞中的DNA修复多酶系统,它可能与人肿瘤细胞对抗癌药的耐药有关。本实验将探讨NER蛋白(XPA,XPB,XPD和ERCC1)的表达与人肿瘤细胞耐药的关系。方法:采用westernblot检测美国国家癌症研究所(NationalCancerInstitute,NCI)用于抗癌药筛选的60株人肿瘤细胞的ERCC1,XPA,XPBXPD表达,并与170种抗癌药物的细胞毒试验结果进行相关性分析。结果:ERCC1,XPB和XPD的蛋白表达与抗癌药物敏感性呈负相关,在170种抗癌药物中分别有13,17和32种的耐药性与上述蛋白水平相关性显著或非常显著(P<0.05)。而XPA的表达与药物敏感性无明显正/负相关。根据已确定的6种药物作用机理分析,肿瘤细胞XPD表达与其对烷化剂类抗癌药耐药相关性显著。结论:本实验结果肿瘤细胞的XPD蛋白表达与烷化剂类抗癌药的耐药相关,提示XPD在肿瘤细胞耐药过程中起重要作用。 | 陈忠平 Areti MALAPETSA Anne MONKS Timothy G. MYERS Gérard MOHR Eaward A. SAUSVILLE Dominic A. SCUDIERO Lawrence C. PANASCI | 2002 | 癌症2002，21，3： | 12 |
| 6 | Supply Chain Coordination with Contracts显示文摘 | Gérard P. Cachon | 2003 | Handbooks in Operations Research and Management Science2003，，： | 9 |
| 7 | 全场彩虹技术测量喷雾浓度及粒径分布显示文摘喷雾颗粒的浓度、粒径等多参数的同时测量是研究喷雾的关键.对应用全场彩虹技术测量双组分液滴的浓度及粒径分布进行了研究.基于改进的Nussenzweig理论,对液滴折射率和粒径分布采用无分布函数算法进行最优化求解,然后通过折射率与浓度的关系反推液滴浓度.用模拟全场彩虹信号对该算法进行了验证,该算法可准确反演具有单峰分布、双峰分布粒径特征的液滴群的折射率与粒径分布.并对体积分数从0%到100%的乙醇溶液喷雾进行了实验测量,结果表明,所测得折射率与理论值符合,粒径分布稳定.该技术在喷雾浓度测量方面具有广阔的应用前景. | 吴迎春 吴学成 Sawitree Saengkaew 姜淏予 洪巧巧 Gérard Gréhan 岑可法 | 2013 | 物理学报2013，62，9： | 9 |
| 8 | Ultrasound-assistant preparation of Cu-SAPO-34 nanocatalyst for selective catalytic reduction of NO by NH_3显示文摘The influence of the various preparation methods of Cu-SAPO-34 nanocatalysts on the selective catalytic reduction of NO with NH3 under excess oxygen was studied. Cu-SAPO-34 nanocatalysts were prepared by using four techniques: conventional impregnation(IM),ultrasound-enhanced impregnation(UIM), conventional deposition precipitation(DP) using Na OH and homogeneous deposition precipitation(HDP) using urea. These catalysts were characterized in detail by various techniques such as N2-sorption, XRD, TEM, H2-TPR,NH3-TPD and XPS to understand the catalyst structure, the nature and the dispersed state of the copper species, and the acid sites for NH3 adsorption. All of the nanocatalysts showed high activities for NO removal. However, the activities were different and followed the sequence of Cu-SAPO-34(UIM) > Cu-SAPO-34(HDP) > Cu-SAPO-34(IM) > Cu-SAPO-34(DP).Based on the obtained results, it was concluded that the NO conversion on Cu-SAPO-34 nanocatalysts was mainly related to the high reducibility of the isolated Cu2+ions and Cu O species, the number of the acid sites and the dispersion of Cu O species on SAPO-34. | Parvaneh Nakhostin Panahi Ali Niaei Darush Salari Seyed Mahdi Mousavi Gérard Delahay | 2015 | Journal of Environmental Sciences2015，27，9： | 7 |
| 9 | 3D palaeogeographic reconstructions of the Phanerozoic versus sea-level and Sr-ratio variations显示文摘A full global geodynamical model over 600 million years(Ma) has been developed at the University of Lausanne during the past 20 years. We show herein how the 2D maps were converted into 3D(i.e., full hypsometry and bathymetry), using a heuristic-based approach. Although the synthetic topography may be viewed as relatively crude, it has the advantage of being applicable anywhere on the globe and at any geological time. The model allows estimating the sea-level changes throughout the Phanerozoic, with the possibility, for the first time, to flood accordingly continental areas. One of the most striking results is the good correlation with 'measured' sea-level changes, implying that long-term variations are predominantly tectonically-driven. Volumes of mountain relief are also estimated through time and compared with strontium isotopic ratio(Sr-ratio), commonly thought to reflect mountain belt erosion. The tectonic impact upon the general Sr-ratio trend is shown herein for the first time, although such influence was long been inferred. | Christian Vérard Cyril Hochard Peter O.Baumgartner Gérard M.Stampfli | 2015 | Journal of Palaeogeography2015，4，1： | 7 |
| 10 | Comparisons between numerical calculations and measurements in vaned diffuser of SHF impeller显示文摘The paper presents analysis of the performance and the internal flow behaviour in the vaned diffuser of a radial flow pump using PIV(particle image velocimetry)and pressure probe traverses.PIV measurements have already been performed at middle height inside one diffuser channel passage for a given speed of rotation and various mass flow rates.These results have been already presented in several previous communications.New experiments have been performed using a three-hole pressure probe traverses from hub to shroud diffuser width at different radial locations between the two diffuser geometrical throats.Numerical simulations are also realized with the commercial codes Star CCM+7.02.011 and CFX.Frozen rotor and fully unsteady calculations of the whole pump have been performed.Comparisons between numerical results,previous experimental PIV results and new probe traverses one's are presented and discussed for one mass flow rate.In this respect,a first attempt to take into account fluid leakages between the rotating and fixed part of the pump has been checked since it may affects the real flow structure inside the diffuser. | Annie-Claude Bayeul-Lainé Patrick Dupont Giovanna Cavazzini Patrick Cherdieu Antoine Dazin Gérard Bois Olivier Roussette | 2013 | 排灌机械工程学报2013，31，12： | 6 |
| 11 | Geodynamic evolution of the Earth over the Phanerozoic:Plate tectonic activity and palaeoclimatic indicators显示文摘During the last decades, numerous local reconstructions based on field geology were developed at the University of Lausanne(UNIL). Team members of the UNIL participated in the elaboration of a 600 Ma to present global plate tectonic model deeply rooted in geological data, controlled by geometric and kinematic constraints and coherent with forces acting at plate boundaries.In this paper, we compare values derived from the tectonic model(ages of oceanic floor, production and subduction rates, tectonic activity) with a combination of chemical proxies(namely CO2, 87Sr/86 Sr, glaciation evidence, and sea-level variations) known to be strongly influenced by tectonics. One of the outstanding results is the observation of an overall decreasing trend in the evolution of the global tectonic activity, mean oceanic ages and plate velocities over the whole Phanerozoic. We speculate that the decreasing trend reflects the global cooling of the Earth system. Additionally, the parallel between the tectonic activity and CO2 together with the extension of glaciations confirms the generally accepted idea of a primary control of CO2 on climate and highlights the link between plate tectonics and CO2 in a time scale greater than 107 yr. Last, the wide variations observed in the reconstructed sea-floor production rates are in contradiction with the steady-state model hypothesized by some. | Christian Vérard Cyril Hochard Peter O.Baumgartner Gérard M.Stampfli | 2015 | Journal of Palaeogeography2015，4，2： | 6 |
| 12 | Prediction of genetic value for sweet cherry fruit maturity among environments using a 6K SNP array显示文摘The timing of fruit maturity is an important trait in sweet cherry production and breeding.Phenotypic variation for phenology of fruit maturity in sweet cherry appears to be under strong genetic control,but that control might be complicated by phenotypic instability across environments.Although such genotype-by-environment interaction(G×E)is a common phenomenon in crop plants,knowledge about it is lacking for fruit maturity timing and other sweet cherry traits.In this study,1673 genome-wide SNP markers were used to estimate genomic relationships among 597 weakly pedigree-connected individuals evaluated over two seasons at three locations in Europe and one location in the USA,thus sampling eight‘environments’.The combined dataset enabled a single meta-analysis to investigate the environmental stability of genomic predictions.Linkage disequilibrium among marker loci declined rapidly with physical distance,and ordination of the relationship matrix suggested no strong structure among germplasm.The most parsimonious G×E model allowed heterogeneous genetic variance and pairwise covariances among environments.Narrow-sense genomic heritability was very high(0.60–0.83),as was accuracy of predicted breeding values(>0.62).Average correlation of additive effects among environments was high(0.96)and breeding values were highly correlated across locations.Results indicated that genomic models can be used in cherry to accurately predict date of fruit maturity for untested individuals in new environments.Limited G×E for this trait indicated that phenotypes of individuals will be stable across similar environments.Equivalent analyses for other sweet cherry traits,for which multiple years of data are commonly available among breeders and cultivar testers,would be informative for predicting performance of elite selections and cultivars in new environments. | Craig M.Hardner Ben J.Hayes Satish Kumar Stijn Vanderzande Lichun Cai Julia Piaskowski JoséQuero-Garcia JoséAntonio Campoy Teresa Barreneche Daniela Giovannini Alessandro Liverani Gérard Charlot Miguel Villamil-Castro Nnadozie Oraguzie Cameron P.Peace | 2019 | Horticulture Research2019，6，1： | 5 |
| 13 | ERCC2诱导表达在人脑胶质瘤细胞对BCNU耐药中的作用显示文摘目的 探讨BCNU诱导ERCC2表达在胶质瘤细胞耐药中的作用。方法 选用ERCC2基础表达在蛋白水平相同 ,而mRNA水平不同的 2株人脑胶质瘤细胞T98 G和SK MG 4(在mRNA水平 ,T98 G比SK MG 4高 2 5倍 ) ,在体外培养时用BCNU处理 ,随后采用WesternBlot测定肿瘤细胞的ERCC2蛋白水平变化。结果 对BCNU耐药的T98 G在BCNU处理后 6h ,ERCC2蛋白水平上升 6倍 ,随后逐渐下降 ,48h回复到基础水平。而对BCNU敏感的SK MG 4,BCNU处理后ERCC2蛋白水平没有增加。结论 本研究提示 ,mRNA基础水平与胶质瘤耐药密切相关 ,在mRNA基础水平较高的肿瘤细胞 ,BCNU能诱导ERCC2蛋白表达 ,并直接与肿瘤耐药相关。 | 陈忠平 Grard Mohr Lawrence C Panasci | 2003 | 中华神经外科杂志2003，19，1： | 5 |
| 14 | 喷锌涂层对球墨铸铁管的防腐蚀保护效应显示文摘采用电化学'二电极'方法,定期测定了沥青和喷锌(130 g/m2)球墨铸铁管在5 g/LNaCl溶液中电位的变化规律,并观察记录试样损伤处首次出现红锈的时间及形貌演变。结果表明:铁的保护电位为-0.780 V,试样电位高于-0.780 V即有红锈出现;相对于沥青涂层,喷锌层对铸铁管防腐蚀提供了有效的阴极保护及自愈合保护,能使首次红锈出现的时间显著延迟。 | 焦俊 陈锋 陈名佶 Gérard NOUAIL 孙恕 | 2007 | 机械工程材料2007，31，11： | 5 |
| 15 | 不可溶性固态内核霾滴的散射及吸收特性分析显示文摘为研究大气环境不可溶性固态内核霾滴的光学性质,以纤维素、石英、聚苯乙烯、赤铁矿及碳黑5种典型凝结核为例,采用核-壳模型计算含不同种类内核霾滴的散射、吸收、消光等效率因子,重点讨论非吸收性内核、弱吸收性内核、强吸收性内核以及霾滴尺度等参数变化对霾滴光学特性的影响。研究结果表明,与吸收性内核霾滴相比,非吸收性内核霾滴的散射较强,PM2.5霾滴的散射与霾滴尺度参数y、内核尺度参数x以及内核复折射率m1等非线性相关;霾滴的吸收效率因子主要取决于内核相对尺度β与内核复折射率。研究结果有助于进一步开展大气雾霾能见度精确评估以及高湿环境多相流复杂介质的激光测量等研究。 | 陈玲红 蒋一奇 孙洋洋 Gérard Grehan 高翔 岑可法 | 2015 | 中国激光2015，42，3： | 4 |
| 16 | 中国传统价值观对于消费行为影响研究——以上海手机市场为例(英文)显示文摘This study investigates how traditional Chinese values influence Chinese consumer behavior directly and indirectly through the impact on people's lifestyles and perceived values.The empirical research is conducted in the context of the mobile phone market in Shanghai.The study establishes measurement scales of Confucian value,lifestyle,and customer perceived value for Chinese market.Relationships of multiple factors are tested in the structural equation model and their impacts on consumer behavior are elaborated.Findings indicate that Confucian values not only have a direct impact on Chinese consumer behavior but also indirectly influence this behavior through impacting people's lifestyles and perceived values. | 潘煜 高丽 陈小燕 Gérard Cliquet | 2011 | China Communications2011，8，3： | 4 |
| 17 | 微尺度碳粒的激光诱导辐射非傅里叶现象分析显示文摘采用热松弛时间表征微纳米含碳粒子受热瞬间热扰动和热响应存在的时间迟滞,同时结合Kn数判断受热粒子所处的流动区域修正空气导热系数,建立亚微米碳粒的单相延迟双曲型瞬态激光诱导辐射传热传质模型,分析碳粒子经高能脉冲激光照射前后其温度与激光诱导辐射光谱强度的时域变化特征。重点讨论了热松弛时间与激光能量等参数对不同粒径尺度的碳粒激光诱导辐射光谱信号的影响。结果表明,热松弛时间值越大,入射激光能量越高,粒径越小,受热颗粒的激光诱导辐射光谱信号振荡幅度越强,非傅里叶效应越显著,这为采用激光诱导辐射技术进行高温环境亚微米量级含碳微粒的定量测量研究提供理论依据。 | 陈玲红 左磊 吴建 Gérard Grehan 岑可法 | 2014 | 中国激光2014，41，4： | 4 |
| 18 | 数字显微全息中记录参数对颗粒测量影响的数值模拟显示文摘数字显微全息技术由于具有三维、非接触和实时测量微小空间内流场的能力,已引起了国内外学者的广泛关注.利用数字显微全息方法测量微通道流场时,记录距离、颗粒尺寸、颗粒浓度、入射光波长、CCD分辨率等参数会对颗粒重建结果产生重要影响.为了评估颗粒浓度和样本空间深度对重建结果的影响,本文开展了数值模拟研究.采用基于洛伦兹-米散射理论的程序产生不同浓度的颗粒全息图,用小波变换重建算法对其进行重建.结果表明:在样本空间深度为24μm时,颗粒浓度ns在3.44×105mm 3—13.77×105mm 3范围内时,颗粒重建率Ep随着颗粒浓度ns的增大而迅速减小,在13.77×105mm 3—55.08×105mm 3范围内时,颗粒重建率Ep随颗粒浓度ns增大而缓慢减少.在颗粒浓度ns(13.77×105mm 3)保持不变时,颗粒重建率Ep与样本空间深度满足单调递减的线性关系.当阴影密度不变时,重建率的变化呈现一定的规律性:当深度L较小时,样本空间深度对颗粒重建的影响要比颗粒浓度的影响大;当深度L较大时,颗粒浓度对颗粒重建的影响较大. | 周斌武 吴学成 吴迎春 阳静 Gérard Gréhan 岑可法 | 2013 | 物理学报2013，62，20： | 3 |
| 19 | Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice显示文摘 | Tiphaine Le Roy Marta Llopis Patricia Lepage Aurélia Bruneau Sylvie Rabot Claudia Bevilacqua Patrice Martin Catherine Philippe Francine Walker André Bado Gabriel Perlemuter Anne-Marie Cassard-Doulcier Philippe Gérard | 2013 | Gut2013，，12： | 3 |
| 20 | Supply Chain Coordination with Revenue-Sharing Contracts: Strengths and Limitations显示文摘 | Gérard P. Cachon Martin A. Lariviere | 2005 | Management Science2005，，： | 3 |
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