|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Omega-3fatty acid supplementation appears to attenuate particulate air pollution-induced cardiac effects and lipid changes in healthy middle-aged adults显示文摘 | TONG H RAPPOLD A G DIAZ-SANCHEZ D | 2012 | Environ Health Perspect2012，120，7： | 1 |
| 3 | Molecu- lar identification of the corticosterone-sensitive extraneuronal catecholamine transporter 显示文摘 | Grundemann D Schechinger B Rappold G A | 1998 | Nat Neurosci1998，1，5： | 1 |
| 4 | Designing multi-echelon serv- ice parts networks with finite repair capacity 显示文摘 | RAPPOLD J A VAN R B D | 2009 | European Jouranl of Operational Research2009，199，3： | 1 |
| 5 | Precipitation analysis and agricultural water availabil- ity in the Southern Highlands of Yemen显示文摘 | Rappold G D | 2005 | Hydrological Process2005，19，2： | 1 |
| 6 | Designing multi-echelon service parts networks with finite repair capacity显示文摘 | Rappold J A Van Roo B D | 2009 | Euro- pean Journal of Operational Research2009，199，3： | 1 |
| 7 | Omega-3 fatty acid supplementation appears to attenuate particulate air pollution–induced cardiac effects and lipid changes in healthy middle-aged adults显示文摘 | TONG H RAPPOLD A G DIAZ-SANCHEZ D | 2012 | Environ Health Perspect2012，120，7： | 1 |
| 8 | Concentrated ambient ultrafine particleexposure induces cardiac changes in young healthy volun-teers显示文摘 | Samet JM Rappold A Graff D Cascio WE Berntsen JH Huang YC | 2009 | Am J Respir Crit Care Med2009，179，11： | 1 |
| 9 | Designing multi-echelon service parts networks with finite repair capacity显示文摘 | Rappold J A Van Roo B D | 2009 | European Journal of Operational Research2009，199，3： | 1 |
| 10 | Guidelines for collaborative supply chain system design and operation 显示文摘 | Muckstadt J A Murray D H Rappold J A | 2001 | Information Systems Frontiers2001，，4： | 1 |
| 11 | Omega-3 fatty acid supplementation appears to attenuate particulate air pollution-induced cardiac effects and lipid changes in healthy middle-aged adults 显示文摘 | Tong H Rappold A G Diaz-Sanchez D | 2012 | Environ Health Perspect2012，120，7： | 1 |
| 12 | Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in healthy young adults显示文摘 | Graft D W Cascio W E Rappold A | 2009 | Environmental Health Perspectives2009，117，7： | 1 |
| 13 | Guidelines for collaborative supply chain system design and operation显示文摘 | Muckstadt J A Murray D H Rappold J A | 2001 | Information Systems Frontiers2001，3，4： | 1 |
| 14 | Exposure to concen- trated coarse air pollution particles causes mild cardiopulmonary effects in healthy young adults显示文摘 | Graft D W Caseio W E Rappold A | 2009 | Environmental Health Per- spectives2009，117，7： | 1 |
| 15 | Designing multi-echelon service parts networks with finite repair capacity 显示文摘 | Rappold J A Van Roo B D | 2009 | European Journal of Operational Research2009，199，3： | 1 |
| 16 | Concentrated ambient ul- trafine particle exposure induces cardiac changes in young healthy volunteers显示文摘 | Samet JM Rappold A Graft D | 2009 | Am J Respir Crit Care Ned2009，179，11： | 1 |
| 17 | Designing multi-echelon service parts networks with finite repair capacity显示文摘 | Rappold J A Van Roo B D | 2009 | European Journal of Operational Research2009，199，3： | 1 |
| 18 | Guidelines for collaborative supply chain system design and operation 显示文摘 | Muckstadt J A Murray D H Rappold J A | 2001 | Information Systems Frontiers2001，3，4： | 1 |
| 19 | Constructability study on a German reference IGCC power plant with and without CO2- capture for hard coal and lignite显示文摘 | Grabner M Morstein O V Rappold D | 2010 | Energy Conversion & Manage- ment2010，51，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员