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| 1 | Radiofrequency ablation for treatment of hypersplenism: A feasible therapeutic option显示文摘We present a case of a patient with hypersplenism secondary to portal hypertension due to hepato-splenic schistosomiasis, which was accompanied by severe and refractory thrombocytopenia. We performed spleen ablation and measured the total spleen and ablated volumes with contrast-enhanced computed tomography and volumetry. No major complications occurred, thrombocytopenia was resolved, and platelet levels remained stable, which allowed for early treatment of the patient's underlying disease. Previous work has shown that splenic radiofrequency ablation is an attractive alternative treatment for hypersplenism induced by liver cirrhosis. We aimed to contribute to the currently sparse literature evaluating the role of radiofrequency ablation(RFA) in the management of hypersplenism. We conclude that splenic RFA appears to be a viable and promising option for the treatment of hypersplenism. | Guilherme Lopes P Martins Joao Paulo G Bernardes Marcello S Rovella Raphael G Andrade Publio Cesar C Viana Paulo Herman Giovanni Guido Cerri Marcos Roberto Menezes | 2015 | World Journal of Gastroenterology2015，21，20： | 17 |
| 2 | Stem cell treatment and cerebral palsy: Systemic review and meta-analysis显示文摘BACKGROUND Perinatal complications may result in life-long morbidities,among which cerebral palsy(CP)is the most severe motor disability.Once developed,CP is a nonprogressive disease with a prevalence of 1-2 per 1000 live births in developed countries.It demands an extensive and multidisciplinary care.Therefore,it is a challenge for our health system and a burden for patients and their families.Recently,stem cell therapy emerged as a promising treatment option and raised hope in patients and their families.AIM The aim is to evaluate the efficacy and safety of stem cell treatment in children with CP using a systematic review and meta-analysis METHODS We performed a systematic literature search on PubMed and EMBASE to find randomized controlled clinical trials(RCT)investigating the effect of stem cell transplantation in children with CP.After the review,we performed a randomeffects meta-analysis focusing on the change in gross motor function,which was quantified using the gross motor function measure.We calculated the pooled standardized mean differences of the 6-and/or 12-mo-outcome by the method of Cohen.We quantified the heterogeneity using the I-squared measure.RESULTS We identified a total of 8 RCT for a qualitative review.From the initially selected trials,5 met the criteria and were included in the meta-analysis.Patients’population ranged from 0.5 up to 35 years(n=282).We detected a significant improvement in the gross motor function with a pooled standard mean difference of 0.95(95%confidence interval:0.13-1.76)favoring the stem cell group and a high heterogeneity(I2=90.1%).Serious adverse events were rare and equally distributed among both intervention and control groups.CONCLUSION Stem cell therapy for CP compared with symptomatic standard care only,shows a significant positive effect on the gross motor function,although the magnitude of the improvement is limited.Short-term safety is present and further highquality RCTs are needed. | Simone Eggenberger Céline Boucard Andreina Schoeberlein Raphael Guzman Andreas Limacher Daniel Surbek Martin Mueller | 2019 | World Journal of Stem Cells2019，11，10： | 8 |
| 3 | GISAID’s Role in Pandemic Response显示文摘GISAID is a global data science initiative and the primary source of genomic and associated metadata of all influenza viruses,Respiratory Syncytial Virus(RSV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the pandemic coronavirus causing coronavirus disease 2019(COVID-19).GISAID’s publicly accessible data sharing platform enables collaboration of over 42,000 participating researchers from 198 nations and data generators from over 3,500 institutions across the globe.Since the first wholegenome sequences were made available by China CDC through GISAID on January 10. | Shruti Khare Céline Gurry Lucas Freitas Mark B Schultz Gunter Bach Amadou Diallo Nancy Akite Joses Ho Raphael TC Lee Winston Yeo GISAID Core Curation Team Sebastian Maurer-Stroh | 2021 | China CDC weekly2021，3，49： | 3 |
| 4 | Enhanced healing of cat corneal endothelial wounds by epidermal growth factor显示文摘 | Raphael B Kerr N C Shimizu R W | 1993 | In- vest Ophthalmol Vis Sci1993，34，7： | 1 |
| 5 | Exome sequencing identifies a DNAJB6 mutation in a family with dominantly- inherited limb-girdle muscular dystrophy显示文摘 | Couthouis J Raphael AR Siskind C | 2014 | Neuromuscul Disord2014，24，： | 1 |
| 6 | Pasture legume species differ in their capacity to acidify soil显示文摘 | Tang C Barton L Raphael C | 1998 | Australian Journal of Agricultural Research1998，49，： | 1 |
| 7 | Limitations of the New York Heart Association functional classification system and self-reported walking distances in chronic heart failure 显示文摘 | Raphael C Briscoe C Davies J | 2007 | Heart2007，93，4： | 1 |
| 8 | Effects that bovine sperm cryopreservation using two different extenders has on sperm membranes and chromatin显示文摘 | Celeghini E C de Arruda R P de Andrade A F Nascimento J Raphael C F Rodrigues P H | | 0，，： | 1 |
| 9 | Data mining techniques for improving the reliability of system identification 显示文摘 | SAiTTA S RAPHAEL B SMITH F C | 2005 | Advanced Engineering Informatics2005，19，4： | 1 |
| 10 | China-Australia training on psychosocial crisis intervention: response to the earthquake disaster in Sichuan显示文摘 | Ng C Ma H Raphael B | 2009 | Australas Psychiatry2009，17，1： | 1 |
| 11 | Predation potential and biology of Protogamasellopsis posnaniensis Wisniewski & Hirschmann (Acari:Rhodacaridae)显示文摘 | Raphael C Castilho Moraes Gilberto J de Silva Edmilson S | 2009 | Biological Control2009，48，： | 1 |
| 12 | The response of burn scars to intralesionsal verapamil 显示文摘 | Raphael C L Howard D Aileen F | 1994 | Arch Surg1994，129，： | 1 |
| 13 | Cryptanalysis of a new ultra-lightweight RFID authentication protocol-SASI显示文摘 | RAPHAEL C W | 2009 | IEEE Transactions on Dependable and Secure Computing2009，6，4： | 1 |
| 14 | Adenoviral-mediated gene transfer into guinea pig cochlear cells in vivo显示文摘 | RAPHAEL Y FRISANCHO J C ROESSLER B J | 1996 | Neurosci Lett1996，207，2： | 1 |
| 15 | Data Mining Techniques for Improving the Reliability of System Identification 显示文摘 | SAITTA S RAPHAEL B SMITH F C | 2005 | Advanced Engineering Informatics Computing in Civil Engineering2005，19，4： | 1 |
| 16 | Nitrogen and carbon uptake kinetics and the influence of irradiance for a red tide bloom off southern California显示文摘 | Raphael M K William P C | 2000 | Aquatic Microbial Ecology2000，21，1： | 1 |
| 17 | Notch signaling and hes labeling in the normal and drug-damaged organ of corti显示文摘 | BATTS S A SHOEMAKER C R RAPHAEL Y | 2009 | Hear Res2009，249，： | 1 |
| 18 | The response of burn sears to intralesional verapamil 显示文摘 | Raphael C Lee MD Howard Doong MS | 1994 | Arch Surg1994，129，1： | 1 |
| 19 | Limitations of the New York Heart Association functional classification system and self-reported waliking distances in chronic heart failure显示文摘 | Raphael C Briscoe C Davies J | | 0，，04： | 1 |
| 20 | Nonlinear optics in fiber grating显示文摘 | Sterke C M Raphael Broderick N G Eggleton B J | 1996 | Optical Fiber Technology1996，，2： | 1 |
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