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| 1 | Clinical Benefit of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors Plus Radiotherapy for Epidermal Growth Factor Receptor-Mutated Metastatic Non-Small Cell Lung Cancer: A Retrospective Analysis on Real World Data显示文摘Objective: To investigate the benefit of epidermal growth factor receptor( EGFR) tyrosine kinase inhibitors( TKIs)with radiotherapy in patients with EGFR mutation-positive metastatic non-small cell lung cancer( NSCLC),compared with TKIs alone.Methods: A total of 103 patients with stage Ⅳ EGFR-mutated NSCLC treated from February 2015 to May 2017 at Sichuan Cancer Hospital were analyzed retrospectively. Fifty patients were treated with EGFR-TKIs( gefitinib or erlotinib) plus radiotherapy( the TKI +RT group) and 53 patients received EGFR-TKIs alone( the TKI group). Tumor response,survival and toxicities were compared between the two groups. Results: Median follow-up time was 11. 7 months( 2. 8-36. 3 months). The overall response rate( ORR) and disease control rate( DCR) in the TKI + RT group vs the TKI group were 62% vs 37. 7%( P = 0. 014) and 88% vs 75. 5%( P =0. 101),respectively. The median progression-free survival( PFS) and median overall survival( OS) in the TKI + RT group were superior to those of the TKI group( 18. 87 months vs 12. 80 months,P = 0. 035 and 23. 10 months vs 18. 30 months,P = 0. 011). OS rates in the TKI + RT group and the TKI group were 56. 0% vs 35. 8% at year 1( P = 0. 04) and 16. 0% vs 3. 8% at year 2( P =0. 036). Multivariate Cox model found that TKI + RT related to significantly better OS( hazard ratio = 0. 209;95% CI,0. 066 to0. 661;P = 0. 008) than TKI alone. Adverse events did not differ significantly between the two groups( P > 0. 050). Conclusion:Compared with EGFR-TKIs alone,EGFR-TKIs combined with radiotherapy was well tolerated and showed benefit in tumor response and survival for EGFR mutation-positive metastatic NSCLC patients. | Wang Ranlin Li Tao Lv Jiahua Sun Chang Shi Qiuling | 2019 | 肿瘤预防与治疗2019，32，5： | 2 |
| 2 | Nucleophilic Aromatic Addition Reactions of the Metallabenzenes and Metallapyridinium: Attacking Aromatic Metallacycles with Bis(diphenylphosphino)methane to Form Metallacyclohexadienes and Cyclic η2‐Allene‐Coordinated Complexes显示文摘 | HongZhang RanLin GuangningHong TongdaoWang Ting BinWen HaipingXia | 2010 | Chemistry – A European Journal2010，，23： | 2 |
| 3 | Tuberculosis of thyroid gland显示文摘 | Ranlin FW | 1932 | Ann Sury1932，96，1： | 1 |
| 4 | Vibration of L-shaped plates under a deterministic force or moment excita- tion: a case of statistical energy analysis application显示文摘 | Tian Ranlin Andy CC Tan ChengYan | 2011 | Journal of Sound and Vibration2011，330，20： | 1 |
| 5 | A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids显示文摘Objective:Organoids are a powerful tool with broad application prospects in biomedicine.Notably,they provide alternatives to animal models for testing potential drugs before clinical trials.However,the number of passages for which organoids maintain cellular vitality ex vivo remains unclear.Methods:Herein,we constructed 55 gastric organoids from 35 individuals,serially passaged the organoids,and captured microscopic images for phenotypic evaluation.Senescence-associatedβ-galactosidase(SA-β-Gal),cell diameter in suspension,and gene expression reflecting cell cycle regulation were examined.The YOLOv3 object detection algorithm integrated with a convolutional block attention module(CBAM)was used to evaluate organoid vitality.Results:SA-β-Gal staining intensity;single-cell diameter;and expression of p15,p16,p21,CCNA2,CCNE2,and LMNB1 reflected the progression of aging in organoids during passaging.The CBAM-YOLOv3 algorithm precisely evaluated aging organoids on the basis of organoid average diameter,organoid number,and number×diameter,and the findings positively correlated with SA-β-Gal staining and single-cell diameter.Organoids derived from normal gastric mucosa had limited passaging ability(passages 1–5),before aging,whereas tumor organoids showed unlimited passaging potential for more than 45 passages(511 days)without showing clear senescence.Conclusions:Given the lack of indicators for evaluating organoid growth status,we established a reliable approach for integrated analysis of phenotypic parameters that uses an artificial intelligence algorithm to indicate organoid vitality.This method enables precise evaluation of organoid status in biomedical studies and monitoring of living biobanks. | Ruixin Yang Yutong Du Wingyan Kwan Ranlin Yan Qimeng Shi Lu Zang Zhenggang Zhu Jianming Zhang Chen Li Yingyan Yu | 2023 | Cancer Biology & Medicine2023，20，7： | 1 |
| 6 | Q2 Switched Ruby laser treatment of tattoos and benign pigmented skin lesions: acritical review显示文摘 | Ranlin C Schonermark MP Greve B | 1998 | Am last Surg1998，41，： | 1 |
| 7 | Effects of tennessee medicaid managed care on obstetrical care and birth outcomes显示文摘 | Conover CJ Ranlin PJ Sloan FA | | 0，，06： | 1 |
| 8 | Tuberculosis of thyroid gland显示文摘 | Ranlin FW | 1932 | Ann Surg1932，96，1： | 1 |
| 9 | Tuberculosis of thyroid gland 显示文摘 | Ranlin FW | 1932 | Ann Sury1932，96，1： | 1 |
| 10 | Bone marrow‐derived cells contribute to cerulein‐induced pancreatic fibrosis in the mouse显示文摘 | Wey‐RanLin OsamuInatomi Chung Y.Lee Yiannis N.Kallis William R.Otto RosemaryJeffery RichardPoulsom Malcolm R.Alison | 2012 | International Journal of Experimental Pathology2012，，2： | 1 |
| 11 | Benchmark for establishment of organoids from gastrointestinal epithelium and cancer based on available consumables and reagents显示文摘Gastrointestinal cancers are a public health problem that threatens the lives of human being. A good experimental model is a powerful tool to promote the uncovering pathogenesis and establish novel treatment methods. High-quality biomedical research requires experimental models to recapitulate the physiological and pathological states of their parental tissues as much as possible. Organoids are such experimental models. Organoids refer to small organlike cellular clusters formed by the expansion and passaging of living tissues in 3D culture medium in vitro.Organoids are highly similar to the original tissues in terms of cellular composition, cell functions, and genomic profiling. Organoids have many advantages, such as short preparation cycles, long-term storage based on cryopreservation, and reusability. In recent years, researchers carried out the establishment of organoids from gastrointestinal mucosa and cancer tissues, and accumulated valuable experiences. In order to promote effective usage and further development of organoid-related technologies in the research of gastrointestinal diseases, this study proposes a benchmark based on utilization of available experimental consumables and reagents, which are involved in the key steps such as collection and pretreatment of biospecimen, organoid construction, organoid cryopreservation and recovery, growth status evaluation, and organoid quality control. We believe that the standard for the construction and preservation of organoids derived from human gastrointestinal epithelium and cancer tissues can provide an important reference for the majority of scientific researchers. | Ruixin Yang Zhen Xiang Ranlin Yan Wingyan Kwan Lu Zang Zhenggang Zhu Yao Qi Yanping Xu Xiaoyan Zhang Hengjun Gao Yingyan Yu | 2023 | Chinese Journal of Cancer Research2023，35，6： | 0 |
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