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| 1 | Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma显示文摘AIM:To investigate the relationship between loss of heterozygosity (LOH) for mannose 6-phosphate/insulin- like growth factor 2 receptor (M6P/IGF2R) and the outcomes for primary HCC patients treated with partial hepatectomy. METHODS: The LOH for M6P/IGF2R in primary HCC patients was assessed using six different gene-specific nucleotide polymorphisms. The patients studied were enrolled to undergo partial hepatectomy. RESULTS: M6P/IGF2R was found to be polymorphic in 73.3% (22/30) of the patients, and of these patients, 50.0% (11/22) had tumors showing LOH in M6P/IGF2R. Loss of heterozygosity in M6P/IGF2R was associated with significant reductions in the two year overall survival rate (24.9% vs 65.5%; P = 0.04) and the disease-free survival rate (17.8% vs 59.3%; P = 0.03). CONCLUSION: These results show M6P/IGF2R LOH predicts poor clinical outcomes in surgically resected primary HCC patients. | Hong Seok Jang Ki Mun Kang Byung Ock Choi Gyu Young Chai Soon Chan Hong Woo Song Ha Randy L Jirtle | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 2 | Elevated blood pressure: Our family's fault?The genetics of essential hypertension显示文摘AIM: To provide an updated review on current genetic aspects possibly affecting essential hypertension(EH), and to further elucidate their role in EH. METHODS: We searched for genetic and epigenetic factors in major studies associated with EH between Jan 2008-Oct 2013 using PubMed. We limited our search to reviews that discussed mostly human studies, and were accessible through the university online re-source. We found 11 genome wide association studies(GWAS), as well as five methylation and three miRNA studies that fit our search criteria. A distinction was not made between genes with protective effects or nega-tive effects, as this article is only meant to be a sum-mary of genes associated with any aspect of EH.RESULTS: We found 130 genes from the studies that met our inclusion/exclusion criteria. Of note, genes withmultiple study references include: STK39, CYP17A1, MTHFR-NPPA, MTHFR-NPPB, ATP2B1, CSK, ZNF652, UMOD, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, CSK-ULK3, CYP1A2, NT5C2, CYP171A, PLCD3, SH2B3, ATXN2, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, and HFE. The following genes overlapped between the genetic studies and epigenetic studies: WNK4 and BDKRB2. Several of the identified genes were found to have functions associated with EH. Many epigenetic factors were also correlated with EH. Of the epigenetic factors, there were no articles discussing siRNA and its effects on EH that met the search criteria, thus the topic was not included in this review. Among the miRNA tar-gets found to be associated with EH, many of the genes involved were also identified in the GWAS studies.CONCLUSION: Genetic hypertension risk algorithms could be developed in the future but may be of limited benefit due to the multi-factorial nature of EH. With emerging technologies, like next-generation sequenc-ing, more direct causal relationships between genetic and epigenetic factors affecting EH will likely be discov-ered creating a tremendous potential for personalized medicine using pharmacogenomics. | Aniket Natekar Randi L Olds Meghann W Lau Kathleen Min Karra Imoto Thomas P Slavin | 2014 | World Journal of Cardiology2014，6，5： | 7 |
| 3 | Thinned arrays using genetic algorithm显示文摘 | Randy L Haupt | 1994 | IEEE Transactions on Antenna and Propagation1994，42，7： | 2 |
| 4 | Phase-only adaptive nulling with a genetic algorithm显示文摘 | Randy L Haupt | 1997 | IEEE Transactions on Antenna and Propagation1997，45，6： | 2 |
| 5 | Effects of Cardiac Resynchronization on Disease Progression in Patients With Left Ventricular Systolic Dysfunction, an Indication for an Implantable Cardioverter-Defibrillator, and Mildly Symptomatic Chronic Heart Failure显示文摘 | William T. Abraham James B. Young Angel R. León Stuart Adler Alan J. Bank Shelley A. Hall Randy Lieberman L Bing Liem John B. O’Connell John S. Schroeder Kevin R. Wheelan | 2004 | Circulation2004，，18： | 1 |
| 6 | Fractal antenna engineering the theory and design of fraetal antennaarrays 显示文摘 | DOUGLAS H W RANDY L H PINGJUAN L W | 1999 | IEEE Antennas And l'ropagtation Magazine1999，，5： | 1 |
| 7 | Crown profile models based on branch attributes in coastal Douglas-fir显示文摘 | RANDY L R DOUGLAS A M | 1997 | For Ecol and Manage1997，96，： | 1 |
| 8 | Bioaccumu- lation of chlorinated pesticides and PCBs in the tropi- cal freshwater ftsb Hoplias malabaricus: Histopathologi- cal, physiological, and immunological findings 显示文摘 | Miranda A L Roche H Randi M A F | 2008 | En- vironment International2008，34，7： | 1 |
| 9 | Aspirin in pregnant pa- tients with essential thrombocythemia: a retrospective analysis of 129 pregnancies显示文摘 | Passamonti F Rumi E Randi M L | 2010 | J Thromb Haemost2010，8，2： | 1 |
| 10 | Extraversion, Neuroticism, and sus- ceptibility to positive and negative affect : a test of two theo- retical models 显示文摘 | Cheryl L R Randy J L | 1997 | Personality and Individual Differences1997，22，5： | 1 |
| 11 | N-acyl-L-homoserine lactones: a class of bacterial quorum-sensing signals alter post-embryonic root de- velopment in Arabidopsis thaliana 显示文摘 | Randy O C Mignel M T Jose L B | 2008 | Plant Cell Environ2008，31，： | 1 |
| 12 | Measurement and analysis of evaporation from an inactive qutdoor swimming pool显示文摘 | Charles C Smith George L f Randy Jones | 1994 | Solar Energy1994，53，1： | 1 |
| 13 | Null synthesis with phase and amplitude controls at the subarray outputs显示文摘 | Haupt Randy L | 1985 | IEEE Transactions on Antenna and Propagation1985，33，5： | 1 |
| 14 | Method for determining frying oil degradation by near-infrared spectroscopy显示文摘 | Choo Lum Ng Randy L Wehling Susan L Cuppet | 2007 | Journal of Agricultural and Food Chemistry2007，，55： | 1 |
| 15 | Soot oxidation: dependence upon initial nanostructure显示文摘 | Randy L Vander Wal Aaron I Tomasek | 2003 | Combustion and Flame2003，134，1： | 1 |
| 16 | Reducing grating lobes due to sub-array amplitude tapering显示文摘 | Haupt Randy L | 1985 | IEEE Transactions on Antennas and Propagations1985，33，8： | 1 |
| 17 | Soot nanostructure: dependence upon synthesis conditions显示文摘 | Randy L Vander Wal Aaron J Tomasek | 2003 | Combustion and Flame2003，，1： | 1 |
| 18 | Views of Nature ofScience questionnaire:Toward Valid and Meaningful Assessmentof learners'Conceptions of Nature of Science显示文摘 | Norm G L Found A Randy L B | 2002 | Journal of Re-search in Science Teaching2002，39，6： | 1 |
| 19 | Initial investigation of effects of fuel oxygenation on nanostructure of soot from a direct - injection diesel engin 显示文摘 | Randy L Vander Wal | 2006 | Energy Fuel2006，20，： | 1 |
| 20 | Biomass to ethanol: A holistic approach using gasification-fermenta- tion显示文摘 | Lewis R S Randy S H Raymond L | 2004 | Abstracts of Papers American Chemical Society2004，227，1： | 1 |
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