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| 1 | DNA methylation-based subclassification of psoriasis in the Chinese Han population显示文摘Psoriasis (Ps)is an inflammatory skin disease caused by genetic and environmental factors.Previous studies on DNA methylation (DNAm)found genetic markers that are closely associated with Ps,and evidence has shown that DNAm mediates genetic risk in Ps.In this study,Consensus Clustering was used to analyze DNAm data,and 114Ps patients were divided into three subclassifications.Investigation of the clinical characteristics and copy number variations (CNVs)of DEFB4,IL22,and LCE3C in the three subclassifications revealed no significant differences in gender ratio and in Ps area and severity index (PASI)score.The proportion of late-onset (≥40 years)Ps patients was significantly higher in type I than in types H and III (P =0.035).Type III contained the smallest proportion of smokers and the largest proportion of non-smoking Ps patients (P =0.086).The CNVs of DEFB4and LCE3C showed no significant differences but the CNV oflL22significantly differed among the three subelassifications (P =0.044).This study is the first to profile Ps subclassifications based on DNAm data in the Chinese Han population.These results are useful in the treatment and management of Ps from the molecular and genetic perspectives. | Fusheng Zhou Changbing Shen Yi-Hsiang Hsu Jing Gao Jinfa Dou Randy KO Xiaodong Zheng Liangdan Sun Yong Cui Xuejun Zhang | 2018 | Frontiers of Medicine2018，12，6： | 3 |
| 2 | Skin diseases in the Da Qing Diabetes Study:a cross-sectional study显示文摘Background:The prevalence of skin diseases and diabetes mellitus(DM)are prominent around the world.The current scope of knowledge regarding the prevalence of skin diseases and comorbidities with type 2 DM(T2DM)is limited,leading to limited recognition of the correlations between skin diseases and T2DM.Methods:We collected 383 subjects from the Da Qing Diabetes Study during the period from July 9th to September 1st,2016.The subjects were categorized into three groups:Normal glucose tolerance(NGT),impaired glucose tolerance(IGT),and T2DM.The prevalence and clinical characteristics of skin diseases were recorded and investigated.Results:In this cross-sectional study,383 individuals with ages ranging from 53 to 89-year-old were recruited.The overall prevalence of skin diseases was 93.5%,and 75.7%of individuals had two or more kinds of skin diseases.Additionally,there were 47 kinds of comorbid skin diseases in patients with T2DM,of which eight kinds of skin diseases had a prevalence>10%.The prevalence of skin diseases in NGT,IGT,and T2DM groups were 93.3%,91.5%,and 96.6%,respectively;stratified analysis by categories showed a statistically significant difference in'disturbances of pigmentation'and'neurological and psychogenic dermatoses'.The duration of T2DM also significantly associated with the prevalence of'disturbances of pigmentation'and'neurological and psychogenic dermatoses'.Subsequently,the prevalence of'disturbances of pigmentation'was higher in males than females in NGT(P<0.01)and T2DM(P<0.01)groups.In addition,the difference in the prevalence of'disturbances of pigmentation'was also significant in NGT and T2DM groups(P<0.01).Conclusions:There was a high prevalence of skin diseases in the Da Qing Diabetes Study.To address the skin diseases in the Da Qing Diabetes Study,increased awareness and intervention measures should be implemented. | Chang-Bing Shen Xin Qian Rui-Xing Yu Xue-Lei Ji Yin-Juan Shi Jing Gao Cheng-Xu Li Ke-Ke Li Wen-Min Fei Xue Shen Zi-Yi Wang Yang Han Xiao-Li Ning Randy Ko Yi-Hsiang Hsu Xian-Yong Yin Guang-Wei Li Yong Cui | 2021 | Chinese Medical Journal2021，，10： | 2 |
| 3 | A rare variant in COL11A1 is strongly associated with adult height in Chinese Han population显示文摘Human height is a highly heritable trait in which multiple genes are involved. Recent genome-wide association studies(GWASs) have identified that COL11A1 is an important susceptibility gene for human height. To determine whether the variants of COL11A1 are associated with adult and children height,we analyzed splicing and coding single-nucleotide variants across COL11A1 through exome-targeted sequencing and two validation stages with a total 20,426 Chinese Han samples. A total of 105 variants were identified by exome-targeted sequencing, of which 30 SNPs were located in coding region. The strongest association signal was chr1_103380393 with P value of 4.8 * 10^(-7). Chr1_103380393 also showed nominal significance in the validation stage(P = 1.21 * 10^(-6)). Combined analysis of 16,738 samples strengthened the original association of chr1_103380393 with adult height(P_(combined)= 3.1 * 10^(-8)), with an increased height of 0.292sd(standard deviation) per G allele(95% CI:0.19-0.40). There was no evidence(P = 0.843) showing that chr1_103380393 altered child height in 3688 child samples. Only the group of 12-15 years showed slight significance with P value of 0.0258.This study firstly shows that genetic variants of COL11A1 contribute to adult height in Chinese Han population but not to children height, which expand our knowledge of the genetic factors underlying height variation and the biological regulation of human height. | Changbing Shen Xiaodong Zheng Jing Gao Caihong Zhu Randy Ko Xianfa Tang Chao Yang Jinfa Dou Yan Lin Yuyan Cheng Lu Liu Shuangjun Xu Gang Chen Xianbo Zuo Xianyong Yin Liangdan Sun Yong Cui Sen Yang Xuejun Zhang Fusheng Zhou | 2016 | Journal of Genetics and Genomics2016，43，9： | 1 |
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