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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Space science applications of cryogenic detectors显示文摘 | Rando N Lumb D Bavdaz M | 2004 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and As- sociated Equipment2004，522，12： | 1 |
| 3 | Cryogenics in space: a review of the missions and of the technologies 显示文摘 | Collaudin B Rando N | 2000 | Cryogenies2000，40，12： | 1 |
| 4 | Space science applications of cryogenic detectors 显示文摘 | RANDO N LUMB D BAVDAZ M | 2004 | Nuclear Instruments & Methods in Physics Research A2004，522，： | 1 |
| 5 | A review on large deploy able structures for astrophysics missions显示文摘 | Puig L Barton A Rando N | 2010 | Acta Astro- nautica2010，67，12： | 1 |
| 6 | Cryogenics in space: a review of the missions and the technologies 显示文摘 | COLLAUDIN B RANDO N | 2000 | Cryogenics2000，40，： | 1 |
| 7 | A review on large deployablestructures for astrophysics missions 显示文摘 | Puig L Barton A Rando N | 2010 | Acta Astronautica2010，67，： | 1 |
| 8 | A review on large deployable structurefor astrophysics missions显示文摘 | Puig L Barton A Rando N | 2010 | Acta Astronautica2010，67，12： | 1 |
| 9 | Cryogenics in space:a review of the missions and of the technologies显示文摘 | Collaudin B Rando N | 2000 | Cryogenics2000，40，： | 1 |
| 10 | A review on large deployable structures for astrophysics missions 显示文摘 | Puig L Barton A Rando N | 2010 | Acta Astronautica2010，67，1： | 1 |
| 11 | A new experimental method for the measurement of the interfacial tension between immiscible fluids at zero bond number显示文摘 | PASSERONE A LIGG1ERI L RANDO N | 1991 | J Colloid Interface Sci1991，146，： | 1 |
| 12 | A review on large deployable structure for astrophysics missions显示文摘 | PUIG L BARTON A RANDO N | 2010 | Acta Astronautica2010，67，12： | 1 |
| 13 | A review on large deployable structures for astrophysics missions 显示文摘 | PUIG L BARTON A RANDO N | 2010 | Acta Astronautica2010，67，1： | 1 |
| 14 | Assessment study of the SPICA telescope assembly 显示文摘 | RANDO N BRUNNER O DOYLE D | 2009 | SPIE2009，7436，74： | 1 |
| 15 | A review on large deployable structures for astrophysics missions 显示文摘 | PUIG L BARTON A RANDO N | 2010 | Acta Astronautica2010，67，1： | 1 |
| 16 | Stability-activity relationship of a family of G-tetrad forming oligonucleotides as potent HIV inhibitors显示文摘 | Jing N Clercq E D RANDO R F | 2000 | J Biol Chem2000，275，5： | 1 |
| 17 | A review on large deployable structures for astrophysics missions显示文摘 | Puig L Barton A Rando N | 2010 | Acta Astronautica2010，67，12： | 1 |
| 18 | Cryogenics in space : a reviews of the missions and of the technologies显示文摘 | Collaudin B Rando N | 2000 | Cryogenics2000，40，12： | 1 |
| 19 | Selection and characterization of human immunodeficiency virus type 1 variants resistant to the (+) and (-) enantiomers of 2'-deoxy-3'-oxa-4'-thio-5-fluorocytidine显示文摘 | Richard N Salomon H Rando R | 2000 | Antimicrob Agents Chemother2000，44，5： | 1 |
| 20 | A retrospeetive analysis of early and late outcome of biodegradable stent placement in the management of refractory anastomotic colorectal strictures 显示文摘 | Repici A Paganu N Rando G e! al | 2013 | Surg Endosc2013，27，7： | 1 |
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