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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | NFkappaB and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells显示文摘 | ZHOU L Z H JOHNSON A P RANDO T A | 2001 | Free Radical Biology and Medicine2001，31，11： | 1 |
| 3 | An allele associated with a non detectable amount of αs2-casein in goat milk 显示文摘 | Ramunno L Pappalardo M Rando A | 2001 | Anim Genet2001，32，： | 1 |
| 4 | Potential acuity meter results in cataract patients显示文摘 | Devereux CJ Rando A Wagstaff CM | 2000 | Clin Experiment Ophthalmol2000，28，6： | 1 |
| 5 | Malignant retroperitoneal paraganglioma:case report and review of the literature显示文摘 | Buonuomo V Ruggiero A Rando G | 2004 | Pediatr Hematol Oncol2004，21，8： | 1 |
| 6 | Primary mouse myoblast purification,characterization,and transplantation for cell-mediated gene therapy显示文摘 | RANDO T A BLAU H M | | 0，，06： | 1 |
| 7 | Molecular characterization of goat CASN1S1 01 allele显示文摘 | Cosenza G Illario R Rando A | 2003 | J Dairy Res2003，70，： | 1 |
| 8 | Primary mouse myoblast purification, characterization, and transplanta- tion for cell-mediated gene therapy 显示文摘 | Rando T A Blau H M | 1994 | J Cell Biol1994，125，6： | 1 |
| 9 | Technology insight:therapy for Duehenne muscular dystrophy-an opportunity for personalized medicine?显示文摘 | LIM L E RANDO T A | 2008 | Nat Clin Pract Neuml2008，4，3： | 1 |
| 10 | Emerging models and paradigms for stem cell ageing显示文摘 | Jones D L Rando T A | 2011 | Nat Cell Biol2011，13，5： | 1 |
| 11 | A review on large deploy able structures for astrophysics missions显示文摘 | Puig L Barton A Rando N | 2010 | Acta Astro- nautica2010，67，12： | 1 |
| 12 | Altered caveolin-3 ex- pression disrupts PI(3)kinase signaling leading to death of cultured muscle cells显示文摘 | Smythe G M Rando T A | 2006 | Experimental Cell Research2006，312，15： | 1 |
| 13 | The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis 显示文摘 | Conboy I M Rando T A | 2002 | Dev Cell2002，3，3： | 1 |
| 14 | Regulation of antioxidant enzyme gene expression in response to oxidative stress and during differentiation of mouse skeletal muscle 显示文摘 | Franco A A Odom R S Rando T A | 1999 | Free Radic Biol Med1999，27，910： | 1 |
| 15 | The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis 显示文摘 | Luo D Renault V M Rando T A | 2005 | Semin Cell Dev Biol2005，16，4： | 1 |
| 16 | Molecular regulation of stem cell quiescence显示文摘 | Cheung T H Rando T A | 2013 | Nat Rev Mol Cell Biol2013，14，6： | 1 |
| 17 | A review on large deployablestructures for astrophysics missions 显示文摘 | Puig L Barton A Rando N | 2010 | Acta Astronautica2010，67，： | 1 |
| 18 | Flexible uretemrenoscopy(URS) : technique and results显示文摘 | Cansino Alcaide JR Reinoso Elbers J Lopez Sanchez D Perez Gonzalez S Rodriguez Aguilera Bazan A Rando Tous A Hidalgo Togores L De La Pena Barthel J | 2010 | Arch Esp Urol2010，63，10： | 1 |
| 19 | Overexpression of Deltex2 inhibits mouse muscle cell differentiation显示文摘 | Luo D Rando T A | 2004 | Mol Biol Cell2004，15，： | 1 |
| 20 | Quality standards in liver surgery: influence of multidisciplinary team work and patient centralization显示文摘 | Rando K Harguindeguy M Leites A | 2010 | Acta Gastroenterol Latinoam2010，40，1： | 1 |
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