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| 1 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 2 | Impaction grafting in the femur in cementless modular revisiontotalhip arthroplasty: a descriptive outcome analysis of 243 cases with the MRP- TITAN revision implant显示文摘 | Wimmer MD Randau TM Deml MC | 2013 | BMC Musculoskelet Disord2013，14，： | 1 |
| 3 | Genetic diversity of Leishmania major strains isolated from different clinical forms of cutaneous leishmaniasis in southern Iran based on minicircle kDNA显示文摘 | Ahmad Oryan Sadegh Shirian Mohammad-Reza Tabandeh Gholam-Reza Hatam Gerrit Randau Yahya Daneshbod | 2013 | Infection, Genetics and Evolution2013，，： | 1 |
| 4 | History of the 2 ~C climate target 显示文摘 | RandaUs S | 2010 | Wiley Intcrdisciplinary Reviews: Climate Change2010，1，4： | 1 |
| 5 | Interleukin-6 in serum and in synovial fluid enhances the differentiation between periprosthetic joint infection and aseptic loosening 显示文摘 | Randau TM Friedrich M J Wimmer MD | 2014 | PLoS One2014，9，89： | 1 |
| 6 | The effect of dexamethasone and triiodothyronine on terminal differentiation of primary bovine chondrocytes and chondrogenically differentiated mesenchymal stem cells显示文摘 | Randau TM Schildberg FA Alini M | 2013 | PLoS One2013，8，72： | 1 |
| 7 | Detection of mutations in Salmonella enterica gyrA, gyrB, parC and pare genes by denaturing high performance liquid chromatography (DH- PLC) using standard HPLC instrumentation显示文摘 | RandaU L P Coldham N G Woodward M J | 2005 | J Antimicrob Chemother2005，56，4： | 1 |
| 8 | Phase formation and reaction in the Bi2O3-ZnO-Nb2O5-Ag pyrochloresystem显示文摘 | NNOJ LANAGAN M T RANDAU C A | 2001 | J Mater Res2001，16，5： | 1 |
| 9 | Tex- ture analysis at neutron diffractometer STRESS-SPEC 显示文摘 | BROKMEIER H G GAN W M RANDAU C | 2011 | Nuclear Instruments and Methods in Physics Re- search A2011，642，： | 1 |
| 10 | Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-depen- dent interferon induction显示文摘 | Childs K RandaU R Goodboum S | 2012 | J Virol2012，86，： | 1 |
| 11 | Is Surgical Education Associated with Additional Costs? A Controlled Economic Study on the German DRG System for Primary TKA显示文摘 | G/Sbel P Piesche K Randau T | 2013 | Z Orthop Unfall2013，151，2： | 1 |
| 12 | An extended X-ray abadsorption fine structure spectroscopy investigation of cadmium adsorption on cryptomelane (KMn8O16显示文摘 | RandaU S R Sherman D M Ragnarsdottir K V | 1998 | Chemical Geology1998，151，： | 1 |
| 13 | Interleukin-6 in serum and in synovial fluid enhances the differentiation between periprosthetic joint infection and aseptic loosening显示文摘 | Randau TM Friedrich MJ Wimmer MD | 2014 | PLoS One2014，9，89： | 1 |
| 14 | Exploiting CRISPR/Cas: interference mechanisms and applications 显示文摘 | Richter H Randau L Plagens A | 2013 | Int J Mol Sci2013，14，14： | 1 |
| 15 | Interleukin-6 in serum and in synovial fluid enhances the differentiation between periprosthetic joint infection and aseptic loosening显示文摘 | Randau TM Friedrich MJ Wimmer MD | 2014 | Plos One2014，9，89： | 1 |
| 16 | Exploiting CRISPR/Cas: Interference mechanisms and applications 显示文摘 | Richter H Randau L Plagens A | 2013 | International journal of molecular sciences2013，14，14： | 1 |
| 17 | Phase formation and reaction in the Bi2O3-ZnO-Nb2O5-Ag pyrochlore system 显示文摘 | Nnoj Lanagan M T Randau C A | 2001 | J Mater Res2001，16，5： | 1 |
| 18 | Exploiting CRISPR/Cas: interference mechanisms and applications 显示文摘 | Richter H Randau L Plagens A | 2013 | Int J Mol Sci2013，14，14： | 1 |
| 19 | Prospective randomized trial of docetaxel versus best supportive care in patients with non- small-cell lung cancer preriously treated wilh platinum-based chemotherapy显示文摘 | Shepherd FA Dancey J Randau | 2000 | J Clin Oncol2000，18，10： | 1 |
| 20 | The rocks and shallows of deep RNA sequencing: Examples in the Vibrio cholerae RNome显示文摘 | Raabe CA Hoe CH Randau G | 2011 | RNA2011，17，7： | 1 |
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