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| 1 | Qualitative Analysis of Xinyue Capsules(心悦胶囊)by High-Performance Liquid Chromatography:Preliminary Evaluation of Drug Quality in A Sino-Austrian Joint Study显示文摘Objective:To develop a reliable method to assess the stability of Xinyue Capsules(心悦胶囊) containing Panax quinquefofius saponins according to European quality standards.Methods:An efficient high-performance liquid chromatography ultraviolet(HPLC-UV) method was established to analyse six main ginsenosides(Rb1,Rb2,Rc,Rd,Re and Rg1) in six different batches(120 capsules/batch) from the same lot of Xinyue Capsules and in one batch measured six times within one day.The six ginsenosides were separated on a Hypersil BDS-C_(18) column(3 μm,100 mm×3 mm) at a flow rate of 0.5 mL/min.Gradient elution was performed using a mobile phase gradient of acetonitrile-water modified with 0.01%formic acid.The HPLC chromatograms were analyzed with TC data comparison' using Lab Solutions software.Results:The HPLC peaks were identified by comparing their retention times(Rg1:23.44 min,Re:23.77 min,Rb1:35.24 min,Rc:36.18 min,Rb2:38.55 min and Rd:40.88 min) with those of the standards under the same chromatographic conditions,which showed similar results among the samples of six different batches and among the samples from one batch detected six times within one day.Conclusions:Xinyue Capsules have good drug intra-day consistency at room temperature and exhibit a consistent quality between different batches.This study established a reliable method to assess the stability of Xinyue Capsules,which is suitable for further qualitative analysis and may assist in promoting the safe and effective use of Chinese herbal medicine. | 薛梅 杨琳 史大卓 Christian Radauer Heimo Breiteneder 马燕 | 2015 | Chinese Journal of Integrative Medicine2015，21，10： | 2 |
| 2 | Allergens are distributed into few protein families and possess a restricted number of biochemical functions 显示文摘 | Radauer C Bublin M Wagner S | 2008 | 3 Allergy Clin Immunol2008，121，： | 1 |
| 3 | Hey 138,the Hevea brasiliensis latex profilin, is a cross-reactive allergen of latex, plant foods and pollen 显示文摘 | Ganglberger E Radauer C Wagner S | 2001 | Int Arch Allergy Immunol2001，125，2： | 1 |
| 4 | The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydruphobic lig- ands 显示文摘 | Radauer C Lackner P Breiteneder H | 2008 | BMC Evolutionary Biology2008，8，1： | 1 |
| 5 | Genomic characterization of members of the Bet v 1 family:genes coding for allergens and pathogenesis-related proteins share intron positions显示文摘 | Hoffmann-Sommergruber K VanekKrebitz M Radauer C | 1997 | Gene1997，197，： | 1 |
| 6 | A classification of plant food allergens显示文摘 | Breiteneder H Radauer C | 2004 | J Allergy Clin hnmunol2004，113，5： | 1 |
| 7 | Cross-reactive and species-specific immunoglobulin E epitopes of plant profilirs:an experimental and structure-based analysis显示文摘 | Radauer C Willerroiderw M Fuchs H | 2006 | Clin Exp Allergy2006，36，7： | 1 |
| 8 | IgE cross-reactivity between the major peanut allergen Ara h 2 and the nonhomologous allergens Ara h 1 and Ara h 3显示文摘 | Merima Bublin Maria Kostadinova Christian Radauer Christine Hafner Zsolt Szépfalusi Eva-Maria Varga Soheila J. Maleki Karin Hoffmann-Sommergruber Heimo Breiteneder | 2013 | The Journal of Allergy and Clinical Immunology2013，，1： | 1 |
| 9 | A classification of plant food allergens显示文摘 | Breiteneder H Radauer C | 2004 | Journal of Allergy and Clinical Immunology2004，113，05： | 1 |
| 10 | Low-Tech,innovation and state aid:the Austrian case 显示文摘 | Alfred Radauer Jlirgen Streicher | 2007 | International Entrepreneurship and Management Journal2007，，3： | 1 |
| 11 | A classification of plant food allergens显示文摘 | Breiteneder H Radauer C | 2004 | J Allergy Clin lmmunol2004，113，83： | 1 |
| 12 | Hev b 8,the Hevea brasiliensis latex profilin,is a cross reactive allergen of latex,plant foods and pollen显示文摘 | Ganglberger E Radauer C Wagner S | 2001 | Int Arch Allergy Immunol2001，125，3： | 1 |
| 13 | A mimotope defined by phage display inhibits IgE binding to the plant panallergen profiling显示文摘 | Leitner A Vogel M Radauer C | 1998 | Eur J Immunol1998，28，： | 1 |
| 14 | A classification of plant food allergens显示文摘 | Breiteneder H Radauer C | 2004 | J Allergy Clin Immunol2004，113，： | 1 |
| 15 | Cloning and molecular characterization of the Hevea brasiliensis allergen Hev b 11,a class Ⅰ chitinase显示文摘 | O'Riordain G Radauer C Hoffmann SK | 2002 | Clin Exp Allergy2002，32，3： | 1 |
| 16 | The Bet v 1 fold: an ancient,versatile scaffold for binding of large,hydrophobic ligands显示文摘 | Radauer C Lackner P Breiteneder H | 2008 | BMC Evol Biol2008，8，1： | 1 |
| 17 | Cloning and molecular characterization of the Hevea brasiliensis allergen Hey b 11, a class Ⅰ chitinase 显示文摘 | O' Riordain G Radauer C Hoffmann-Sommergruber K | 2002 | Clin Exp Allergy2002，32，： | 1 |
| 18 | Characterization of crossreactive bell pepper allergens involved in the latex-fruit syndrome显示文摘 | Wagner S Radauer C Hafner C | 2004 | Clin Exp Allergy2004，34，11： | 1 |
| 19 | Low-tech,innovation and state aid:the Austrian case显示文摘 | RADAUER A STREICHER J | 2007 | International Entrepreneurship and Management Journal2007，3，3： | 1 |
| 20 | Genomic characterization of members of the Bet vl family: Genes coding for allergens and pathogene- sis-related proteins share intron positions显示文摘 | HOFFMANN -SOMMERGRUBER K VANEK-KREBITZ M RADAUER C | 1997 | Gene1997，197，12： | 1 |
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