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| 1 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 2 | Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis显示文摘AIM To understand the influence of chronic kidney disease(CKD) on mortality, need for transfusion and rebleeding in gastrointestinal(GI) bleeding patients.METHODS A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or endstage renal disease(ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization(LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and I2 statistics. Mean difference(MD) and OR(odds ratio) were calculated.RESULTS1063 articles(EMBASE: 589; PubM ed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group(OR = 1.786, 95%CI: 1.689-1.888, P < 0.001) and the ESRD group(OR = 2.530, 95%CI: 1.386-4.616, P = 0.002), and a rebleeding rate(OR = 2.510, 95%CI: 1.521-4.144, P < 0.001) in patients with impaired renal function. CKD patients required more unit red blood cell transfusion(MD = 1.863, 95%CI: 0.812-2.915, P < 0.001) and spent more time in hospital(MD = 13.245, 95%CI: 6.886-19.623, P < 0.001) than the controls.CONCLUSION ESRD increases mortality, need for transfusion, rebleeding rate and LOH among GI bleeding patients. Prospective patient registries and observational clinical trials are crucially needed. | Roland Hágendorn Nelli Farkas Aron Vincze Zoltán Gyongyi Dezso Csupor Judit Bajor Bálint Eross Péter Csécsei Andrea Vasas Zsolt Szakács László Szapáry Péter Hegyi Alexandra Mikó | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 3 | Association between high-sensitivity cardiac troponin T and N-terminal pro-brain natriuretic peptide in a community based population显示文摘 | Xu RY Ye P Luo LM Sheng L Wu HM Xiao WK Zheng J Wang F Xiao TH | 2014 | Chinese Medical Journal2014，，4： | 2 |
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| 6 | An enhanced volumetric CT study 显示文摘 | Carlier RY Safa DM Parva P Ankylosing neurogenic myositis ossificans of the hip | 2005 | J Bone Joint Surg Br2005，87，3： | 1 |
| 7 | Mechanically induced osteogenic differentiation--the role of RhoA,ROCKII and cytoskeletal dynamics显示文摘 | Arnsdorf EJ Tummala P Kwon RY Jacobs CR | | 0，，： | 1 |
| 8 | Radiography-based treatment planning compared with computed tomography(CT)-based treatment planning for intracavitary brachytherapy in cancer of the cervix:analysis of close-volume histograms显示文摘 | Kim RY Pareek P | 2003 | Brachytherapy2003，2，： | 1 |
| 9 | Genotype and allele frequency of the 27-bp tandem repeat polymorphism in the endothelial nitric oxide synthase gene in Chinese population显示文摘 | Lu P Lu X Xing RY | 2001 | Yi Chuan Xue Bao2001，28，12： | 1 |
| 10 | Development of a simple,noninvasive,clinically relevant model of pressure ulcers in the mouse显示文摘 | Tadler I Zhang RY Oskoui P | 2004 | J Invest Surg2004，17，4： | 1 |
| 11 | Management of splenic artery aneurysms:the significance of portal and essential hypertension显示文摘 | LEE P C RHEE RY GORDON RY | | 0，，05： | 1 |
| 12 | Proteomic analysis of dendritic cell-derived exosomes:a secreted subcellular compartment distinct from apoptotic vesicles显示文摘 | Théry C Boussac M Véron P | 2001 | J Immunol2001，166，12： | 1 |
| 13 | Changes in globus palli-dus with (pre) term kernicterus 显示文摘 | Govaert P Lequin M Swarte RY | 2003 | Pediatrics2003，112，6： | 1 |
| 14 | Mesenteric venous thrombosis: still a lethal disease in the 1990s显示文摘 | Rhee RY Gloviczki P Mendonca CT | 1994 | J Vasc Surg1994，20，5： | 1 |
| 15 | The plica syndrome,a syndrome of controversy显示文摘 | Kinnard P Levesque RY | 1984 | Clin Orthop1984，，183： | 1 |
| 16 | Analysis of plasma proteome from cases of the different traditional Chinese medicine syndromes in patients with chronic hepatitis B显示文摘 | Liu YP Liu P Dai RY | 2012 | J Pharm Biomed Anal2012，59，1： | 1 |
| 17 | Guidelines for the early management of adults with ischemic stroke显示文摘 | Harold P Adams J Grego ry DZ | 2007 | Stroke2007，38，6： | 1 |
| 18 | Gene expression profiling reveals that peripheral nerve regeneration is a consequence of both novel injury-dependent and reactivated developmental processes显示文摘 | Bosse F Hasenpusch-Theil K Küry P | | 0，，： | 1 |
| 19 | Mesenteric venous thrombosis:stiLL a LethaL disease in the 1990s显示文摘 | Rhee RY Gloviczki P Mendonca CT | 1994 | J Vasc Surg1994，20，5： | 1 |
| 20 | Mesenteric enous thrombosis:still a lethal disease in the 1990s显示文摘 | Rhee RY Gloiczki P Mendonca CT | 1994 | J asc Surg1994，20，5： | 1 |
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