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| 1 | Epidemiology of inflammatory bowel disease in South America: A systematic review显示文摘BACKGROUND The worldwide epidemiology of inflammatory bowel disease(IBD)is rapidly changing.Increasing Crohn’s disease(CD)and ulcerative colitis(UC)incidence and prevalence have been recorded in developing regions such as Asia,Africa and Eastern Europe where it was previously thought to be uncommon.Whether this is also the case in South America is not well known.Demonstration that developing regions worldwide have increasing IBD incidence would indicate that environmental change plays a significant role in the development of IBD.AIM To report the incidence,prevalence and disease characteristics of CD and UC within the South American continent.METHODS A systematic review was conducted by searching published studies in major international and regional databases(MEDLINE,EMBASE and Scopus)between January 1990 and December 2018.Outcomes considered were incidence,prevalence,phenotype,environmental and genetic factors,ethnicity and gender.A pair of independent reviewers screened and reviewed all identified articles.RESULTS One hundred and sixty two citations were initially retrieved with 18 studies included in this systematic review.The majority of included studies were from Brazil(n=13,72%).The incidence of UC ranged from 4.3-5.3/100000 personyears whilst the incidence of CD ranged from 0.74-3.5/100000 person-years.Prevalence ranged from 15.0-24.1/100000 inhabitants for UC and from 2.4-14.1/100000 inhabitants for CD.The incidence and prevalence of both UC and CD has increased significantly in Brazil over the past 21 years.Pancolitis was the most common disease distribution in patients with UC whilst colonic involvement was the most common distribution in CD.People residing in urban areas were at higher risk of developing both CD and UC.CONCLUSION The IBD burden in South America is increasing at a rate possibly even greater than other developing regions around the world.There is a paucity of highquality epidemiological studies and further robust and representative data are required to further explore modifiable risk factors and disease phenotypes. | Sriharan Selvaratnam Santiago Gullino Lisa Shim Eric Lee Alice Lee Sudarshan Paramsothy Rupert W Leong | 2019 | World Journal of Gastroenterology2019，25，47： | 5 |
| 2 | Epidemiological studies of migration and environmental risk factors in the inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBD)are idiopathic chronic diseases of the gastrointestinal tract well known to be associated with both genetic and environmental risk factors.Permissive genotypes may manifest into clinical phenotypes under certain environmental influences and these may be best studied from migratory studies.Exploring differences between first and second generation migrants may further highlight the contribution of environmental factors towards the development of IBD.There are few opportunities that have been offered so far.We aim to review the available migration studies on IBD,evaluate the known environmental factors associated with IBD,and explore modern migration patterns to identify new opportunities and candidate migrant groups in IBD migration research. | Yanna Ko Rhys Butcher Rupert W Leong | 2014 | World Journal of Gastroenterology2014，20，5： | 5 |
| 3 | Current application of proteomics in biomarker discoveryfor inflammatory bowel disease显示文摘Recently, the field of proteomics has rapidly expanded in its application towards clinical research with objectives ranging from elucidating disease pathogenesis to discovering clinical biomarkers. As proteins govern and/or reflect underlying cellular processes, the study of proteomics provides an attractive avenue for research as it allows for the rapid identification of protein profiles in a biological sample. Inflammatory bowel disease(IBD) encompasses several heterogeneous and chronic conditions of the gastrointestinal tract. Proteomic technology provides a powerful means of addressing major challenges in IBD today, especially for identifying biomarkers to improve its diagnosis and management. This review will examine the current state of IBD proteomics research and its use in biomarker research. Furthermore, we also discuss the challenges of translating proteomic research into clinically relevant tools. The potential application of this growing field is enormous and is likely to provide significant insights towards improving our future understanding and management of IBD. | Patrick PY Chan Valerie C Wasinger Rupert W Leong | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 5 |
| 4 | Preparation of Rapeseed Oil Ester of Lower Aliphatic Alcohols显示文摘 | Dragan N Rupert P Manfred W | 2000 | JAOCS2000，77，3： | 1 |
| 5 | 查看详情显示文摘 | Matthews D L Campbell E M Ceglio N M Hermes G Kauffman R Koppel L Lee R Manes K Rupert V Slivinsky W Turner R Ze F | | 0，，： | 1 |
| 6 | Evaluation of a Series of Bieyelic CXCR2 Antagonists 显示文摘 | lain W Caroline A Rupert A | 2008 | Bioorg Med Chem Lett2008，18，： | 1 |
| 7 | Coupled B-snake grids and constrained thin-plate splines for analysis of 2-D tissue deformations from tagged MRI显示文摘 | Amini Amir A Chen Yasheng Curwen Rupert W | 1998 | IEEE Transactions on Medical Imaging1998，17，3： | 1 |
| 8 | Confocal laser endomicroscopy in the diagnosis of celiac disease显示文摘 | RUPERT W ANDRE K BERNARD W | 2006 | Gastrointest Endosc2006，63，5： | 1 |
| 9 | Evaluationof a Series of Bicyclic CXCR2 Antagonists显示文摘 | IAIN W CAROLINE A RUPERT A | 2008 | BioQrgMed Chem Lett2008，18，2： | 1 |
| 10 | Energy partitioning and microstructural observations related to perforation of tita nium and steel targets 显示文摘 | Rupert N L Grace F I Haung W | 1997 | International Journal of Impact Engineering1997，20，： | 1 |
| 11 | Adapta- tion and conservation of physiological systems in the evo- lution of human hypoxia tolerance 显示文摘 | HOCHACHKA P W RUPERT J I MONGE C | 1999 | Comparative Bio- chemistl7 and Physiology Part A : Molecular & Integrative Physiology1999，124，1： | 1 |
| 12 | Adaptation and conserveation of physiologyical systems in the evolution of human hypoxia tolerance显示文摘 | Hochachka P W Rupert J L Monge C | 1999 | Comp Biochem Physiol Part A1999，124，： | 1 |
| 13 | Application of a drill resistance technique for density profile measurement in wood composite panels显示文摘 | PAUL M W WEI W RUPERT W | 1995 | Composites & Manufactured Products1995，45，6： | 1 |
| 14 | Evaluation of a series of bicyclie CXCR2 antagonists显示文摘 | Iain W Caroline A Rupert A | 2008 | Bioorg Med Chem Lett2008，18，： | 1 |
| 15 | Proteomics and metabolomics in inflammatory bowel disease显示文摘 | Yunki Yau Rupert W Leong Ming Zeng Valerie C Wasinger | 2013 | J Gastroenterol Hepatol2013，，7： | 1 |
| 16 | Going malig- nant: the hypoxia-cancer connection in the prostate显示文摘 | Hochachka P W Rupert J L Goldenberg L | 2002 | Bioes says2002，24，8： | 1 |
| 17 | Measuring safety and efficiency in the operating room:development and validation of a metric for evaluating task execution in the operating room显示文摘 | STEPHANIE R SONAL A RUPERT W | 2013 | J Am Coll Surg2013，216，3： | 1 |
| 18 | Preparation of rapeseed oil ester of lower aliphatic alcohols显示文摘 | Dragan N Rupert P Manfred W Richard G | 2000 | JAOCS2000，77，3： | 1 |
| 19 | 显示文摘 | Dragan N Rupert P Manfred W | 2000 | JAOCS2000，77，3： | 1 |
| 20 | Structure and mechanism of anthocyanidin synthase from Arabidopsis thali- ana 显示文摘 | Rupert C W Jonathan J T Richard W D | 2002 | Structure2002，10，： | 1 |
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