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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Rhenium behavior in molybdenite in hypogene and near surface environments : Implications for Re-Os geochronometry 显示文摘 | McCandless T E Ruiz J Campbell A R | 1993 | Geochimica et Cosmochimica Acta1993，57，： | 1 |
| 3 | An evolutionary multiobjective framework for structural damage localization and quantification显示文摘 | Perera R Ruiz A Manzano C | | 0，，10： | 1 |
| 4 | Countercurrent supercritical fluid extraction and fractionation of alcoholic heverages显示文摘 | Senorans F J Ruiz R A Ihanez E | 2001 | J Agric Food Chem2001，49，4： | 1 |
| 5 | A computer model for teaching the dynamic behavior of AC contac- tors显示文摘 | RUIZ J R ESPINOSA A G ROMERAL L | 2010 | IEEE Transactions on Education2010，53，2： | 1 |
| 6 | Uncertainty management in the uint commitment problem显示文摘 | Ruiz P A Philbrick C R Zak E | 2009 | IEEE Transactions on Power Systems2009，24，2： | 1 |
| 7 | Performance evaluation of existing approaches for hybrid ad hoc networks across mobility models显示文摘 | FRANCISCO R J RUIZ P M GOMEZ S A | 2006 | Journal of Net Works2006，1，2： | 1 |
| 8 | Online assessment and control of transient oscillations damping显示文摘 | Ruiz V D Messina A R Pabella M | 2004 | IEEE Transactions on Power Systems2004，19，2： | 1 |
| 9 | A multistage FE updating procedure for damage identification in large-seale structures based on multi-objective evolutionary optimization 显示文摘 | PERERA R RUIZ A | 2008 | Mechanical Systems and Signal Processing2008，22，4： | 1 |
| 10 | Sauna-induced Rapid Weight Loss Decreases Explosive Power in Women butnot in Men显示文摘 | GUTIERREZ A MESA J L RUIZ J R | 2003 | Int J Sports Med2003，24，7： | 1 |
| 11 | Cellular localization and changes in expression of prolactin receptor isoforms in sheep ovary throughout the estrous cycle显示文摘 | Picazo R A Garcia Ruiz J P Santiago Moreno J | 2004 | Reproduction2004，128，5： | 1 |
| 12 | Effect of the welding profile generated by the modified indirect electric arc technique on the fatigue behavior of 6061-T6 aluminum alloy显示文摘 | AMBRIZ R R MESMACQUE C~ RUIZ A AMROUCHE A LOPEZ V H | 2010 | Materials Science and Engineering A2010，527，78： | 1 |
| 13 | Lower plasma NAMPT/visfatin levels are associated with impaired hepatic mitochon-drial function in non-diabetic obese women:a potential linkbetween obesity and non-alcoholic fatty liver disease显示文摘 | RUIZ J R LASA A SIMON E | 2012 | Nutrition Metabolism and Cardiovascular Diseases2012，22，2： | 1 |
| 14 | Kinetics of stibnite (Sb2S3) oxidation at roasting temperaturas显示文摘 | PADILLA R ARACENA A RUIZ MARiA C | 2014 | Journal of Mining and Metallurgy2014，50，： | 1 |
| 15 | The effect of pon- deral index at birth on the relationships between common LEP and LEPR polymorphisms and adiposity in adoles- cents 显示文摘 | Idoia L R Ruiz L A Moreno F B | 2011 | Obesity2011，19，10： | 1 |
| 16 | Sternoclavicular brucellosis 显示文摘 | Ibafiez R Ruiz P Garcia-Chill6n A | 1987 | J Rheumatol1987，14，1： | 1 |
| 17 | Purification and N- terminal Amino Acid Sequence of Enterocin CRL 35, a ' Pediocin -like' Bacteriocin Produced by Enterococcus faecium CRL35显示文摘 | Farias M E Farias R N de Ruiz H A | 1996 | Lett Appl Microbiol1996，22，6： | 1 |
| 18 | Melatonin improves glucose ho- meostasis in young Zucker diabetic fatty rats 显示文摘 | Agil A Rosado I Ruiz R | 2012 | J Pineal Res2012，52，2： | 1 |
| 19 | The-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagu- lated patients 显示文摘 | MONTES R RUIZ DE GAONA E MARTINEZ-GONZALEZ M A | 2006 | Br J Haematol2006，133，2： | 1 |
| 20 | Discharge of Nutrients from Shrimp Farming to Coastal Waters of the Gulf of California显示文摘 | Paez-osuna F Guerrro S R Ruiz A C | 1999 | Marine Pollution Bulletin1999，38，7： | 1 |
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