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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Separation of liquid-liquid dispersions in a deep-layer gravity settler: Part I Experimental study of the separation process 显示文摘 | Padilla R Ruiz M C Trujillo W | 1996 | Hydrometallurgy1996，42，2： | 1 |
| 3 | Acute respiratory distress syndrome in trauma patients : ICU mortality and prediction factors 显示文摘 | Navarrete - Navarro P Ruiz -Bailen M Rinera Fernandez R | 2000 | Intensive Care Med2000，26，： | 1 |
| 4 | Lead isotope compositions of Late Cretaceous and early Tertiary igneous rocks and sulfide minerals in Arizona; implications for the sources of plutons and metals in porphyry copper deposits 显示文摘 | Bouse R M Ruiz J Titley S R | 1999 | Economic Geology1999，94，2： | 1 |
| 5 | Performance evaluation of existing approaches for hybrid ad hoc networks across mobility models显示文摘 | FRANCISCO R J RUIZ P M GOMEZ S A | 2006 | Journal of Net Works2006，1，2： | 1 |
| 6 | Online assessment and control of transient oscillations damping显示文摘 | Ruiz V D Messina A R Pabella M | 2004 | IEEE Transactions on Power Systems2004，19，2： | 1 |
| 7 | Unbalanced collagenases/TIMP-1 expression and epithelial apoptosis in experimental lung fibrosis显示文摘 | RUIZ V ORDONE R M BERUMEN J | 2003 | Am J Physiol Lung Cell Mol Physiol2003，285，5： | 1 |
| 8 | Activator protein 2alpha inhibits tumorigenicity and represses vascular endothelial growth factor transcription in prostate cancer cells 显示文摘 | RUIZ M PETTAWAY C SONG R | 2004 | Cancer Res2004，64，2： | 1 |
| 9 | Purification and N- terminal Amino Acid Sequence of Enterocin CRL 35, a ' Pediocin -like' Bacteriocin Produced by Enterococcus faecium CRL35显示文摘 | Farias M E Farias R N de Ruiz H A | 1996 | Lett Appl Microbiol1996，22，6： | 1 |
| 10 | Dirofilaria immitis in an African lion(Panthera leo ) 显示文摘 | RUIZ DE YBANEZ M R MARTINEZ-CARRASCO C MAR- TINEZ J J | 2006 | Vet Rec2006，158，7： | 1 |
| 11 | Resistance to cold and heat stress: accumulation of phenolic compounds in tomato and watermel- on plants显示文摘 | Rivem R M Ruiz J M Garcia P C | 2001 | Plant Science2001，160，： | 1 |
| 12 | The-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagu- lated patients 显示文摘 | MONTES R RUIZ DE GAONA E MARTINEZ-GONZALEZ M A | 2006 | Br J Haematol2006，133，2： | 1 |
| 13 | Acetaldehyde metabolism in lactic acid bacteria显示文摘 | Raya R R Manca De Nadra M C Pesee De Ruiz Hoigado A | 1986 | Milchwissenschaft1986，41，： | 1 |
| 14 | Analysis of the field of physical chemistry of urfactants with the unified scienctometric model fit of relational and activity indicators 显示文摘 | BAILON M R JURADO A E RUIZ B R | 2005 | Scientometrics2005，63，2： | 1 |
| 15 | Effect of variables on thequality of hematite precipitated from sulfate solutions 显示文摘 | RUIZ M C ZAPATA J PADILLA R | 2007 | Hydrometallurgy2007，89，2： | 1 |
| 16 | Chemical burns:pathophysiology and treatment显示文摘 | Palao R Monge I Ruiz M | 2010 | Burns2010，36，3： | 1 |
| 17 | Microcellular Foaming of Polymethylmethacrylate in a Bath Supercritical CO2 Process: Effect of Microstructure on Compression Behavior显示文摘 | RUIZ J A R VIOT P DUMON M | 2010 | Journal of Applied Polymer Science2010，118，1： | 1 |
| 18 | Deaths associated with liposuction:case reports and review of the literature显示文摘 | KOHLER L J RUIZ R | 2002 | J Forensic Sci2002，47，1： | 1 |
| 19 | Study of the enantiomeric composition of chiral constituents in edible oils by simultaneous distillation-extraction, detection of adulterated olive oils 显示文摘 | CAJA M M RUIZ del CASTILLO M L R HERRAIZ M | 1999 | Journal of the American Oil Chemists'' Society1999，76，9： | 1 |
| 20 | Analytical speciation as a tool to assess arsenic behaviour in soils polluted by mining显示文摘 | RUIZ C M J LOPEZ S J F RUBIO R | 2007 | Analytical and Bioanalytical Chemistry2007，387，： | 1 |
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