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| 1 | Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding显示文摘AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received carvedilol.METHODS Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic response.RESULTS Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with carvedilol.CONCLUSION Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects for reducing portal pressure. | José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Characteristics of the heterotrophic population in hypersaline environments of different salt concentration显示文摘 | RODRIGUEZ V F RUIZ B F RAMOS C A | 1981 | Microbiol Ecol1981，7，： | 1 |
| 4 | Effect of dryi/lg medium on residual moisture content and viability of freeze - dried Lactic acid bacteria显示文摘 | De Valdez G F De Giori G S De Ruiz Holgado A P | | 0，，02： | 1 |
| 5 | Comparative study of the efficiency of some additives in protecting lactic acid bacteria against freeze-drying 显示文摘 | De Valdez G F de Giori G S de Ruiz Holgado A P | 1983 | Cryobiology1983，20，： | 1 |
| 6 | Countercurrent supercritical fluid extraction and fractionation of alcoholic heverages显示文摘 | Senorans F J Ruiz R A Ihanez E | 2001 | J Agric Food Chem2001，49，4： | 1 |
| 7 | Bile salts hydrolase plays a key role on cho- lesterol removal by Lactobacillus reuteri显示文摘 | TARANTO M P SESMA F DE RUIZ HOLGADO A P | 1997 | Biotech- nology Letters1997，19，9： | 1 |
| 8 | Fast and selective determination of triterpenic compounds in olive leaves by liquid chromatography tandem mass spectrometry with multiple reaction monitoring after microwave-assisted extraction显示文摘 | SANCHEZ A N PRIEGO C F RUIZ J J | 2009 | Talanta2009，78，1： | 1 |
| 9 | Context-dependent signal integration by the GLI code:The oncogenic load,pathways,modifiers and implications for cancer therapy显示文摘 | Aberger F Ruiz I Altaba A | 2014 | Semin Cell Dev Biol2014，，： | 1 |
| 10 | Design and validation of a rehabilitation robotic exoskeleton for tremor assessment and suppression显示文摘 | ROCON E BELDA-LOIS J M RUIZ A F | | 0，，03： | 1 |
| 11 | Modelling Austenite Flow Curves in Low Alloy and Microalloyed Steels显示文摘 | Hernandez C A Medina S F Ruiz J | 1996 | Acta Materialia1996，44，1： | 1 |
| 12 | The effect of pon- deral index at birth on the relationships between common LEP and LEPR polymorphisms and adiposity in adoles- cents 显示文摘 | Idoia L R Ruiz L A Moreno F B | 2011 | Obesity2011，19，10： | 1 |
| 13 | Modeling austenite flow curve in low alloy and microalloyed steel显示文摘 | HERNADEZ C A MEDINA S F RUIZ J | 1996 | Acta Mater1996，44，1： | 1 |
| 14 | Non-axis-symmetrical punching shear around internal columns of RC slabs without transverse reinforcement 显示文摘 | SAGASETA J MOTTONI A RUIZ M F | 2011 | Mag Concrete Res2011，63，6： | 1 |
| 15 | Manna:a management architecture for wireless sensor networks显示文摘 | NOGUEIRA J M LOUREIRO A F | 2003 | IEEE Communication Magazine2003，41，： | 1 |
| 16 | Discharge of Nutrients from Shrimp Farming to Coastal Waters of the Gulf of California显示文摘 | Paez-osuna F Guerrro S R Ruiz A C | 1999 | Marine Pollution Bulletin1999，38，7： | 1 |
| 17 | calcifying fibrous pseudotumor : clinicopathologic study of 15 cases and analysis of its relationship to inflammatory myofibroblastic tumor 显示文摘 | ALESSANDR A F NASCIMENTO A F RUIZ R | 2002 | Int J Surg Pathol2002，10，3： | 1 |
| 18 | Cycle scheduling with oral contraceptive pills in the GnRH antagonist protocol vs the long protocol: a randomized, controlled trial 显示文摘 | Garcia Velasco JA Bermejo A Ruiz F | 2011 | Fertil Stcril2011，96，： | 1 |
| 19 | Coal mine methane:a review of capture and utilization practices with benefits to mining safety and to greenhouse gas reduction显示文摘 | Karacan C (O) Ruiz F A Cotè M | | 0，，： | 1 |
| 20 | Genetic variability related to serum uric acid concentration and risk of Parkinson’s disease显示文摘 | Isabel González‐Aramburu Pascual Sánchez‐Juan Silvia Jesús Ana Gorostidi Eduardo Fernández‐Juan Fátima Carrillo María Sierra Pilar Gómez‐Garre María T. Cáceres‐Redondo José Berciano Javier Ruiz‐Martínez Onofre Combarros Pablo Mir Jon Infante | 2013 | Mov Disord2013，，： | 1 |
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