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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Sequential (step-by-step) detection, identification and quantitation of extra virgin olive oil adulterationby chemometric treatment of chromatographic profiles 显示文摘 | F Priego Capot J Ruiz Jira6nez M D Luque de Castro | 2007 | Anal Bioanal Chem2007，388，： | 1 |
| 3 | Dispersive orderings and characterizations of aging classes显示文摘 | BELZUNCE F CANDEL J RUIZ J M | 1996 | Statistics and Probability Letters1996，28，4： | 1 |
| 4 | A structural damage detection indicator based on principal component analysis and statistical hypothesis testing 显示文摘 | Mujica L E Ruiz M Pozo F | 2014 | Smart Materials and Structures2014，23，2： | 1 |
| 5 | Experimental study of mismatch and shading effects in the I-V characteristic of a photovoltaic module 显示文摘 | ALONSO-GARCIA M C RUIZ J M CHENLO F | 2006 | Solar Energy Materials & Solar Cells2006，90，3： | 1 |
| 6 | The dilation order,the dispersion order,and orderings of residual lives显示文摘 | BELZUNCE F PELLEREY F RUIZ J M | 1997 | Statistics and Probability Letters1997，33，3： | 1 |
| 7 | Bile salts hydrolase plays a key role on cho- lesterol removal by Lactobacillus reuteri显示文摘 | TARANTO M P SESMA F DE RUIZ HOLGADO A P | 1997 | Biotech- nology Letters1997，19，9： | 1 |
| 8 | Punching of flat slabs supported on rectangular columns 显示文摘 | Sagaseta J Tassinari L Ruiz M F | 2014 | Engineering Structures2014，77，： | 1 |
| 9 | Available options in the management of non-typhi Salmonella 显示文摘 | Ruiz M Rodr f guez JC Escribano I | 2004 | Expert Opin Pharmacother2004，5，8： | 1 |
| 10 | Experimental study of mismatch and shading effects in the I-V characteristic of a photovoltaic module 显示文摘 | ALONSO-GARC1A M C RUIZ J M CHENLO F | 2006 | Solar Energy Materials and Solar Cells2006，90，3： | 1 |
| 11 | Design and validation of a rehabilitation robotic exoskeleton for tremor assessment and suppression显示文摘 | ROCON E BELDA-LOIS J M RUIZ A F | | 0，，03： | 1 |
| 12 | Global spread of microorganisms by ships显示文摘 | Ruiz G M Rawlings T K Dobbs F C | 2000 | Nature2000，408，6808： | 1 |
| 13 | Experimental study of mismatch and shading effects in the I-V characteristic of a photovoltaic module 显示文摘 | ALONSOGARCIA M C RUIZ J M CHENLO F | 2006 | Solar Energy Materials & Solar Cells2006，，90： | 1 |
| 14 | Recycling of an electric arc furnace flue dust to obtain high grade ZnO显示文摘 | RUIZ 0 CLEMENTE C ALONSO M ALGUACIL F J | 2007 | Journal of Hazardous Materials2007，141，1： | 1 |
| 15 | Non-axis-symmetrical punching shear around internal columns of RC slabs without transverse reinforcement 显示文摘 | SAGASETA J MOTTONI A RUIZ M F | 2011 | Mag Concrete Res2011，63，6： | 1 |
| 16 | Manna:a management architecture for wireless sensor networks显示文摘 | NOGUEIRA J M LOUREIRO A F | 2003 | IEEE Communication Magazine2003，41，： | 1 |
| 17 | Analytical speciation as a tool to assess arsenic behaviour in soils polluted by mining显示文摘 | RUIZ C M J LOPEZ S J F RUBIO R | 2007 | Analytical and Bioanalytical Chemistry2007，387，： | 1 |
| 18 | Coal mine methane:a review of capture and utilization practices with benefits to mining safety and to greenhouse gas reduction显示文摘 | Karacan C (O) Ruiz F A Cotè M | | 0，，： | 1 |
| 19 | New approaches to the extraction of arsenic species from soils显示文摘 | RUIZ C M J SABE R LOPEZ S J F | 2005 | Microchimica Acta2005，151，： | 1 |
| 20 | Solution-based synthesis route to(Bi1-xPbx)2Sr2Ca2Cu3O10+δ显示文摘 | Ruiz M T Fuente G F Badía A | 1993 | J Mater Res1993，8，6： | 1 |
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