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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Sequential (step-by-step) detection, identification and quantitation of extra virgin olive oil adulterationby chemometric treatment of chromatographic profiles 显示文摘 | F Priego Capot J Ruiz Jira6nez M D Luque de Castro | 2007 | Anal Bioanal Chem2007，388，： | 1 |
| 3 | Nutrient losses by runoff and sediment from the taluses of orchard terraces显示文摘 | Zuazo V H D Raya A M Ruiz J A | 2004 | Water Air &Soil Pollution2004，153，： | 1 |
| 4 | The influence of market heterogeneity on the relationship between a destination's image and tourists' future behaviour显示文摘 | Castro C B Armario E M Ruiz D M | 2007 | Tourism Management2007，28，1： | 1 |
| 5 | A solvent-free synthesis of coumarins using a Wells-Dawson heteropolyacid as catalyst显示文摘 | Romanelli G P Bennardi D Ruiz D M | 2004 | Tetrahedron Letters2004，45，48： | 1 |
| 6 | Modulation of renal disease in MRL/Ipr mice by suberoylanilide hydroxamic acid 显示文摘 | Reilly C M Mishra N Miller J M Joshi D Ruiz P Riehon V M | 2004 | J ImmunoI2004，173，： | 1 |
| 7 | Online assessment and control of transient oscillations damping显示文摘 | Ruiz V D Messina A R Pabella M | 2004 | IEEE Transactions on Power Systems2004，19，2： | 1 |
| 8 | Psoriatic arthritis: a clinical entity distinct from psoriasis? 显示文摘 | Ruiz D G Azevedo M N Santos O L | 2012 | Rev Bras Reumatol2012，52，4： | 1 |
| 9 | Factors contributing to the uncertainty in circumaural earphone calibration for audiometric test 显示文摘 | RUIZ M FEUEREISEN B MACHON D RECUERO M | 2005 | Applied Acoustics2005，66，9： | 1 |
| 10 | Role and therapeu-tic potential of VEGF in the nervous system显示文摘 | Ruiz de AC Lambrechts D Mazzone M | 2009 | Physiol Rev2009，89，： | 1 |
| 11 | The influence of market het- erogeneity on the relationship between a destinations image and tourists' future behavior显示文摘 | Castro C B Armario E M Ruiz D M | 2007 | Tourism Management2007，28，1： | 1 |
| 12 | The intuence of market heterogeneity on the relationship between a destina- tion's image and tourists' future behaviour 显示文摘 | CASTROR C B ARMARIO E M RUIZ D M | 2007 | Tourism Management2007，28，： | 1 |
| 13 | Role and therapeutic potential of VEGF in the nervous system显示文摘 | Ruiz de Almodovar C Lambrechts D Mazzone M | 2009 | Physiol Rev2009，89，2： | 1 |
| 14 | Tissue micro array analysis of ganglioside N-glycolyl GM3 expression and signal transducer and activator of transcription(STAT)-3 activation in relation to dendritic cell infiltration and microvessel density in non-small cell lung cancer显示文摘 | VAN C H RUIZ M G VAN D V P | 2009 | BMC Cancer2009，9，： | 1 |
| 15 | Changes in muscle collagen content during post mortem storage of farmed sea bream (Sparus aurata) : influence on textural properties 显示文摘 | SUAREZ M D ABAD M RUIZ C T | 2005 | Aquaculture international2005，13，4： | 1 |
| 16 | Free spermidine and spermine content in Lotus glaber under long-term salt stress显示文摘 | SANCHEZ D H CUEVAS J C CHIESA M A RUIZ O A | 2005 | Plant Science2005，168，： | 1 |
| 17 | Molecular characterization and evaluation of mycorrhizal capacity of SuiUus isolates from central spain for the selection of fungal inoculants 显示文摘 | Ruiz D B Rinc6n A M Felipe M R | 2006 | Mycorrhiza2006，16，7： | 1 |
| 18 | Effect of Inhibition of Na +/Ca2 + Exchanger at the Time of Myocardial Reperfusion on Hypercontracture and Cell Death显示文摘 | Inserte J Garvia D D Ruiz M M | 2002 | Cardiovasc Res2002，54，4： | 1 |
| 19 | Measurement of aortic valve annulus using different cardiac imaging techniques in transcatheter aortic valve implantation: agreement with finally implanted prosthesis size显示文摘 | Mesa Rubio D Suarez de Lezo Cruz Conde J Alvarez-Osorio M P Ruiz Ortiz M Delgado Ortega M Leon del Pino Mdel C | 2011 | Echocardiography2011，28，： | 1 |
| 20 | Initiation and Maintenance of Vires-Induced Gene Silencing显示文摘 | Ruiz M T Voinnet O Baulcombe D C | 1998 | The Plant Cell1998，10，： | 1 |
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