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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Using the polymerase chain reaction coupled with denaturing gradient gel electrophoresis to investigate the association between bacterial translocation and systemic inflammatory response syndrome in predicted acute severe pancreatitis显示文摘AIM: To investigate the use of PCR and DGGE to investigate the association between bacterial translocation and systemic inflammatory response syndrome in predicted severe AP.METHODS: Patients with biochemical and clinical evidence of acute pancreatitis and an APACHE Ⅱ score ≥8 were enrolled. PCR and DGGE were employed to detect bacterial translocation in blood samples collected on d1,3, and 8 after the admission. Standard microbial blood cultures were taken when there was clinical evidence of sepsis or when felt to be clinically indicated by the supervising team.RESULTS: Six patients were included. Of all the patients investigated, only one developed septic complications;the others had uneventful illness. Bacteria were detected using PCR in 4 of the 17 collected blood samples. The patient with sepsis was PCR-positive in two samples (taken on d 1 and 3), despite three negative blood cultures. Using DGGE and specific primers, the bacteria in all blood specimens which tested positive for the presence of bacterial DNA were identified as E coli.CONCLUSION: Our study confirmed thatunlike traditional microbiological techniques, PCR can detect the presence of bacteria in the blood of patients with severe AP. Therefore, this latter method in conjunction with DGGE is potentially an extremely useful tool in predicting septic morbidity and evaluating patients with the disease. Further research using increased numbers of patients, in particular those patients with necrosis and sepsis, is required to assess the reliability of PCR and DGGE in the rapid diagnosis of infection in AP. | Callum B Pearce Vitaly Zinkevich Iwona Beech Viera Funjika Ana Garcia Ruiz Afraa Aladawi Hamish D Duncan | 2005 | World Journal of Gastroenterology2005，11，45： | 11 |
| 3 | Stem cell therapy in the management of shoulder rotator cuff disorders显示文摘Rotator cuff tears are frequent shoulder problems that are usually dealt with surgical repair. Despite improved surgical techniques, the tendon-to-bone healing rate is unsatisfactory due to difficulties in restoring the delicate transitional tissue between bone and tendon. It is essential to understand the molecular mechanisms that determine this failure. The study of the molecular environment during embryogenesis and during normal healing after injury is key in devising strategies to get a successful repair. Mesenchymal stem cells(MSC) can differentiate into different mesodermal tissues and have a strong paracrine, anti-inflammatory, immunoregulatory and angiogenic potential. Stem cell therapy is thus a potentially effective therapy to enhance rotator cuff healing. Promising results have been reported with the use of autologous MSC of different origins in animal studies: they have shown to have better healing properties, increasing the amount of fibrocartilage formation and improving the orientation of fibrocartilage fibers with less immunologic response and reduced lymphocyte infiltration. All these changes lead to an increase in biomechanical strength. However, animal research is still inconclusive and more experimental studies are needed before human application. Future directions include expanded stem cell therapy in combination with growth factors or different scaffolds as well as new stem cell types and gene therapy. | Maria Valencia Mora Miguel A Ruiz Ibán Jorge Díaz Heredia Raul Barco Laakso Ricardo Cuéllar Mariano García Arranz | 2015 | World Journal of Stem Cells2015，7，4： | 6 |
| 4 | 2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia显示文摘 | Dinesh Khanna John D. Fitzgerald Puja P. Khanna Sangmee Bae Manjit K. Singh Tuhina Neogi Michael H. Pillinger Joan Merill Susan Lee Shraddha Prakash Marian Kaldas Maneesh Gogia Fernando Perez‐Ruiz Will Taylor Frédéric Lioté Hyon Choi Jasvinder A. Singh Ni | 2012 | Arthritis Care Res2012，，10： | 4 |
| 5 | Nitrification with high nitrite accumulation for the treatment of wastewater with high ammonia concentration显示文摘 | G Ruiz D Jeison R Chamy | 2002 | Water Research2002，，6： | 2 |
| 6 | 2012 American College of Rheumatology guidelines for management of gout. Part 2: Therapy and antiinflammatory prophylaxis of acute gouty arthritis显示文摘 | Dinesh Khanna Puja P. Khanna John D. Fitzgerald Manjit K. Singh Sangmee Bae Tuhina Neogi Michael H. Pillinger Joan Merill Susan Lee Shraddha Prakash Marian Kaldas Maneesh Gogia Fernando Perez‐Ruiz Will Taylor Frédéric Lioté Hyon Choi Jasvinder A. Singh Ni | 2012 | Arthritis Care Res2012，，10： | 2 |
| 7 | Measuring and modelling the soil shrinkage characteristic curve显示文摘 | W.M. Cornelis J. Corluy H. Medina J. Díaz R. Hartmann M. Van Meirvenne M.E. Ruiz | 2006 | Geoderma2006，，1： | 2 |
| 8 | Clinical characteristics and type of antithrombotic treatment in a Spanish cohort of elderly patients with atrial fibrillation according to dependency, frailty and cognitive impairment显示文摘根据相关性,脆弱和认知缺陷与 atrial 纤维性颤动(AF ) 考虑老病人的临床的侧面和管理的 BackgroundAvailable 数据是少见的。学习的目的是根据相关性分析 biodemographic 数据,临床的侧面和 antithrombotic 治疗,吗在patients.MethodsCross部分的老 AF 和学习在 75 年与 3 个月在 Spain.ResultsA 在内部药部门出席了的口头的抗凝剂对待的连续 AF 病人执行了的多中心的脆弱和认知缺陷 837 总计病人( 83.0 ???????????????????吗???????????????????￡?? | Jose Maria Mostaza Manuel Jesús Romero Jiménez Fernando José Ruiz Laiglesia José Antonio Díaz Peromingo Manuel Beltrán Robles Ernesto Guevara Sierra Ana Santander Bilbao Carmen Suárez | 2018 | Journal of Geriatric Cardiology2018，15，4： | 2 |
| 9 | Sequential (step-by-step) detection, identification and quantitation of extra virgin olive oil adulterationby chemometric treatment of chromatographic profiles 显示文摘 | F Priego Capot J Ruiz Jira6nez M D Luque de Castro | 2007 | Anal Bioanal Chem2007，388，： | 1 |
| 10 | Nutrient losses by runoff and sediment from the taluses of orchard terraces显示文摘 | Zuazo V H D Raya A M Ruiz J A | 2004 | Water Air &Soil Pollution2004，153，： | 1 |
| 11 | Surface Chemical Reactivity in Selected Zero-Valent Iiron Samples Used in Groundwater Remediation显示文摘 | Ruiz N Seal S Reinhart D | 2000 | Journal of Hazardous Materials2000，80，13： | 1 |
| 12 | Nitrification with high nitrite accumulation for the treatment of wastewater with high ammonia concentration显示文摘 | RUIZ G JEISON D CHAMY R | 2003 | Water Research2003，37，6： | 1 |
| 13 | Nitrification with high nitrite accumulation for the treatment of wastewater with high ammonia concentration显示文摘 | Ruiz G Jeison D Chamy R | 2003 | Wat Res2003，37，6： | 1 |
| 14 | The influence of market heterogeneity on the relationship between a destination's image and tourists' future behaviour显示文摘 | Castro C B Armario E M Ruiz D M | 2007 | Tourism Management2007，28，1： | 1 |
| 15 | Improved outcome in high-grade aneurysmal subarachnoid hemorrhage by enhancement of endogenous clearance of cisternal blood clots:a prospective study that demonstrates the roles of lamina terminalis fenestration combined with modern microsurgical cisternal blood evacuation显示文摘 | Mura J Rojas-Zalazar D Ruiz A | 2007 | Minim Invasive Neurosurg2007，50，6： | 1 |
| 16 | A solvent-free synthesis of coumarins using a Wells-Dawson heteropolyacid as catalyst显示文摘 | Romanelli G P Bennardi D Ruiz D M | 2004 | Tetrahedron Letters2004，45，48： | 1 |
| 17 | Influence of hydrogen on the magnetic: properties of terfenol-D显示文摘 | Ruiz D Angulo L Abell J S | 1994 | J Appl Phys1994，76，： | 1 |
| 18 | Dormancy in temperate fruit trees in a global warming context:A review显示文摘 | Campoy J A Ruiz D Egea J | | 0，，02： | 1 |
| 19 | Modulation of renal disease in MRL/Ipr mice by suberoylanilide hydroxamic acid 显示文摘 | Reilly C M Mishra N Miller J M Joshi D Ruiz P Riehon V M | 2004 | J ImmunoI2004，173，： | 1 |
| 20 | Online assessment and control of transient oscillations damping显示文摘 | Ruiz V D Messina A R Pabella M | 2004 | IEEE Transactions on Power Systems2004，19，2： | 1 |
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