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| 1 | Evaluation of the effect of geometrical parameters on stope probability of failure in the open stoping method using numerical modeling显示文摘Stress-induced failure is among the most common causes of instability in Canadian deep underground mines.Open stoping is the most widely practiced underground excavation method in these mines,and creates large stopes which are subjected to stress-induced failure.The probability of failure(POF)depends on many factors,of which the geometry of an open stope is especially important.In this study,a methodology is proposed to assess the effect of stope geometrical parameters on the POF,using numerical modelling.Different ranges for each input parameter are defined according to previous surveys on open stope geometry in a number of Canadian underground mines.A Monte-Carlo simulation technique is combined with the finite difference code FLAC3D,to generate model realizations containing stopes with different geometrical features.The probability of failure(POF)for different categories of stope geometry,is calculated by considering two modes of failure;relaxation-related gravity driven(tensile)failure and rock mass brittle failure.The individual and interactive effects of stope geometrical parameters on the POF,are analyzed using a general multi-level factorial design.Finally,mathematical optimization techniques are employed to estimate the most stable stope conditions,by determining the optimal ranges for each stope’s geometrical parameter. | Shahriyar Heidarzadeh Ali Saeidi Alain Rouleau | 2019 | International Journal of Mining Science and Technology2019，29，3： | 9 |
| 2 | Influence of cardiac nerve status on cardiovascular regulation and cardioprotection显示文摘Neural elements of the intrinsic cardiac nervous system transduce sensory inputs from the heart, blood vessels and other organs to ensure adequate cardiac function on a beat-to-beat basis. This inter-organ crosstalk is critical for normal function of the heart and other organs; derangements within the nervous system hierarchy contribute to pathogenesis of organ dysfunction. The role of intact cardiac nerves in development of, as well as protection against, ischemic injury is of current interest since it may involve recruitment of intrinsic cardiac ganglia. For instance, ischemic conditioning, a novel protection strategy against organ injury, and in particular remote conditioning, is likely mediated by activation of neural pathways or by endogenous cytoprotective bloodborne substances that stimulate different signalling pathways. This discovery reinforces the concept that inter-organ communication, and maintenance thereof, is key. As such, greater understanding of mechanisms and elucidation of treatment strategies is imperative to improve clinical outcomes particularly in patients with comorbidities. For instance, autonomic imbalance between sympathetic and parasympathetic nervous system regulation can initiate cardiovascular autonomic neuropathy that compromises cardiac stability and function. Neuromodulation therapies that directly target the intrinsic cardiac nervous system or other elements of the nervous system hierarchy are currently being investigated for treatment of different maladies in animal and human studies. | John G Kingma Denys Simard Jacques R Rouleau | 2017 | World Journal of Cardiology2017，9，6： | 6 |
| 3 | Rockburst in underground excavations:A review of mechanism,classification,and prediction methods显示文摘Technical challenges have always been part of underground mining activities,however,some of these challenges grow in complexity as mining occurs in deeper and deeper settings.One such challenge is rock mass stability and the risk of rockburst events.To overcome these challenges,and to limit the risks and impacts of events such as rockbursts,advanced solutions must be developed and best practices implemented.Rockbursts are common in underground mines and substantially threaten the safety of personnel and equipment,and can cause major disruptions in mine development and operations.Rockbursts consist of violent wall rock failures associated with high energy rock projections in response to the instantaneous stress release in rock mass under high strain conditions.Therefore,it is necessary to develop a good understanding of the conditions and mechanisms leading to a rockburst,and to improve risk assessment methods.The capacity to properly estimate the risks of rockburst occurrence is essential in underground operations.However,a limited number of studies have examined and compared yet different empirical methods of rockburst.The current understanding of this important hazard in the mining industry is summarized in this paper to provide the necessary perspective or tools to best assess the risks of rockburst occurrence in deep mines.The various classifications of rockbursts and their mechanisms are discussed.The paper also reviews the current empirical methods of rockburst prediction,which are mostly dependent on geomechanical parameters of the rock such as uniaxial compressive strength of the rock,as well as its tensile strength and elasticity modulus.At the end of this paper,some current achievements and limitations of empirical methods are discussed. | Mahdi Askaripour Ali Saeidi Alain Rouleau Patrick Mercier-Langevin | 2022 | Underground Space2022，7，4： | 3 |
| 4 | Echocardiographic assessment of the interventricalar delay of activation and correlation to the QRS width in dilated cardiomyopathy显示文摘 | Rouleau F Merheb M Geffroy S | 2001 | Pacing Clinical Elec trophysiology2001，24，： | 1 |
| 5 | Kinematic analysis of the cervical spine following implantation of an artificial cervical disc显示文摘 | Pickett GE Rouleau JP Duggal N | | 0，，： | 1 |
| 6 | Internal fixation of osteopenic acetabular fractures involving the quadrilateral plate 显示文摘 | LAFLAMME G Y HEBEKT-DAVIES J ROULEAU D | 2011 | Injury2011，42，10： | 1 |
| 7 | PARP inhibitionPARP1 and beyond显示文摘 | Rouleau M Patel A Hendzel M J | 2010 | Nat Rev Cancer2010，10，4： | 1 |
| 8 | Targeting poly (ADPribosyl) ation: a promising approach in cancer therapy 显示文摘 | Hainee JF Rouleau M Hendzel M J | 2005 | Trends Mol Med2005，11，10： | 1 |
| 9 | Cognitive deficits associated with sleep apnea syndrome: a proposed neuropsychological test battery显示文摘 | Dcary A Rouleau I Montplaisir J | 2000 | Sleep2000，23，： | 1 |
| 10 | Neuro-ophthalmic sarcoidosis:the University of Iowa experience显示文摘 | Koczman JJ Rouleau J Gaunt M | 2008 | Semin Ophthalmol2008，23，3： | 1 |
| 11 | Performance of a Microwave Sensor for the Precise Measurement of Water Vapor in Gases 显示文摘 | Rouleau J F Goyette J Boses T K | 2000 | IEEE Transactions on Dielectrics and Electrical Insulation2000，7，6： | 1 |
| 12 | Accumulation of waterbome mercury(Ⅱ) in specific areas of fish brain显示文摘 | Rouleau C Borg Neczak K Gottofrey J | 1999 | ES & T1999，333，： | 1 |
| 13 | Internal fixation of osteopenie acetabular fractures involving the quadrilateral plate 显示文摘 | Laflamme G'Y Hebert-Davies J Rouleau D | 2011 | Injury2011，42，10： | 1 |
| 14 | Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers显示文摘 | Bagley RG Weber W Rouleau C | 2009 | Int J Oncol2009，34，3： | 1 |
| 15 | Improved outcome after acute coronary syndromes with an intensive versus standard lipid-lowering regimen:results from the pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22 (PROVE IT-TIMI 22) trial显示文摘 | ROULEAU J | 2005 | Am J Med2005，118，12： | 1 |
| 16 | Prognostic value of neurohumoral activation in patients with an acute myocardial infarction:effect of captopril显示文摘 | Rouleau JL Packer M Moye L | 1994 | Am Coll Cardiol1994，24，11： | 1 |
| 17 | Laparoscopy - asssisted aortobifemoral bypass 显示文摘 | Dion YM Katkhouda N Rouleau C | 1993 | Surg Laparosc Endosc1993，3，： | 1 |
| 18 | Internal fixation of osteopenic ace- tabular fractures involving the quadrilateral plate 显示文摘 | Laflamme GY Hebert - Davies J Rouleau D | 2011 | Injury2011，42，10： | 1 |
| 19 | Effect of simvastatin on Kruppel-like factor2,endothelial nitric oxide aynthase and thrombomodulin expression in endotheli al cells under shear stress显示文摘 | Rossi J Rouleau L Tardif JC | | 0，，： | 1 |
| 20 | Accurate measurement of greater tuberosity displacement without computed tomography:valida- tion of a method on plain radiography to guide surgical treatment显示文摘 | Mutch J Rouleau DM Laflamme GY | 2013 | Orthop Trauma2013，1，： | 1 |
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