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| 1 | Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial显示文摘 | JY Douillard D Cunningham AD Roth M Navarro RD James P Karasek P Jandik T Iveson J Carmichael M Alakl G Gruia L Awad P Rougier | 2000 | The Lancet2000，，9209： | 4 |
| 2 | G蛋白信号转导调节因子5的缺失激活脑卒中时的神经血管保护显示文摘在缺血性脑卒中发生时,血脑屏障的破坏加重了脑损伤。周细胞脱离导致血脑屏障破坏和神经血管功能障碍,但对其在脑卒中中的调节知之甚少。在该研究中,研究者研究了周细胞中G蛋白信号转导调节因子5(Gprotein signaling5,RGS5)的缺失如何影响脑卒中时血脑屏障的破坏及其后果。 | zen I Roth M Barbariga M Gaceb A Deierborg T Genové G Paul G 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 2 |
| 3 | Hepatocellular carcinoma after Iocoregional therapy:Magnetic resonance imaging findings in falsely negative exams显示文摘AIM:To elucidate causes for false negative magnetic resonance imaging(MRI)exams by identifying imaging characteristics that predict viable hepatocellular carcinoma(HCC)in lesions previously treated with locoregional therapy when obvious findings of recurrence are absent.METHODS:This retrospective institutional review board-approved and Health Insurance Portability and Accountability Act-compliant study included patients who underwent liver transplantation at our center between 1/1/2000 and 12/31/2012 after being treated for HCC with locoregional therapy.All selected patients had a contrast-enhanced MRI after locoregional therapy within 90 d of transplant that was prospectively interpreted as without evidence of residual or recurrenttumor.Retrospectively,2 radiologists,blinded to clinica and pathological data,independently reviewed the pre transplant MRIs for 7 imaging features.Liver explan histopathology provided the reference standard,with clinically significant tumor defined as viable tumor≥1.0cm in maximum dimension.Fisher’s exact test was firs performed to identify significant imaging features.RESULTS:Inclusion criteria selected for 42 patients with 65 treated lesions.Fourteen of 42 patients(33%and 16 of 65 treated lesions(25%)had clinically significant viable tumor on explant histology.None o the 7 imaging findings examined could reliably and reproducibly determine which treated lesion had viable tumor when the exam had been prospectively read as without evidence of viable HCC.CONCLUSION:After locoregional therapy some treated lesions that do not demonstrate any MRI evidence o HCC will contain viable tumor.As such even patients with a negative MRI following treatment should receive regular short-term imaging surveillance because some have occult viable tumor.The possibility of occult tumo should be a consideration when contemplating any action which might delay liver transplant. | David Becker-Weidman Jesse M Civan Sandeep P Deshmukh Christopher G Roth Steven K Herrine Laurence Parker Donald G Mitchell | 2016 | World Journal of Hepatology2016，8，16： | 2 |
| 4 | Feasibility and efficacy of routine PCR screening of blood donations for hepatitis virus and HIV-1 in a blood bank setting 显示文摘 | Roth WK Weber M Seifried E | 1999 | Lancet1999，353，9150： | 2 |
| 5 | Numerical calculation of the reflection,absorption,and transmission of microwaves by a nonuniform plasma slab 显示文摘 | Laroussi M Roth J R | 1993 | IEEE Trans Plasma Sci1993，21，4： | 2 |
| 6 | Geometric primitive extraction using a genetic algorithm显示文摘 | Roth G Levin M D | 1994 | IEEE Trans on PAMI1994，16，9： | 2 |
| 7 | The cost of hospitalization in Crohn’s disease显示文摘 | Russell D Cohen Leanne R Larson Joel M Roth Russell V Becker Lisa L Mummert | 2000 | The American Journal of Gastroenterology2000，，2： | 2 |
| 8 | Satellite derived urban heat islands from three coastal cities and the utilization of such data in urban climatology 显示文摘 | Roth M Oke T R and Emery W J | 1989 | International Journal of Remote Sensing1989，10，11： | 2 |
| 9 | 'Thiocyanate gold':small (2~3 nm) colloidal gold for affinity labeling in electron microscopy显示文摘 | Bashong W Lucocq J M Roth J | 1985 | Histochemistry1985，83，： | 1 |
| 10 | Ordered mesoporous molecular sieves synthesized by a liquid crystal templates mechanism显示文摘 | Kresge C T Leonowicz M E Roth W J | 1992 | Nature1992，359，6397： | 1 |
| 11 | Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism显示文摘 | Kressge C T Leonowicz M E Roth W J | 1992 | Nature1992，359，： | 1 |
| 12 | The shuttle radar topography mission-a new class of digital elevation models acquired by spaceborne radar 显示文摘 | Rabus B Eineder M Roth A | 2003 | ISPRS Journal of Photograrnmetry and Remote Sending2003，57，4： | 1 |
| 13 | Increased matrix metalloproteinase activation in esophageal squamous cell carcinoma显示文摘 | Mukherjee S Roth M J Dawsey SM et ai | | J Transl Med0，，1： | 1 |
| 14 | Slope stability analysis by strength reduction显示文摘 | DAWSON E M ROTH W H DRESCHER A | 1999 | Geotechnique1999，49，6： | 1 |
| 15 | 显示文摘 | Roth S Stoca M Degmova J | 2006 | J Magn Magn Mater2006，304，2： | 1 |
| 16 | Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism 显示文摘 | Kresge C T Leonowicz M E Roth W J | 1992 | Nature1992，359，： | 1 |
| 17 | Mechanistic model of retention in protein ion-exchange chromatography显示文摘 | ROTH C M UNGER K K LENHOFF A M | 1996 | J Chromatogr A1996，726，： | 1 |
| 18 | Mechanism of polybrominated diphenyl ether uptake into the liver: PBDE congeners are substrates of human hepatic OATP transporters 显示文摘 | Pacyniak E Roth M Hagenbuch B | 2010 | Toxicol Sci2010，115，2： | 1 |
| 19 | Ordered mesoporous molecular sieves syntherized by a liquid-crystal template mechanism显示文摘 | KRESGE C T LEONOWlCZ M E ROTH W J | 1992 | Nature1992，359，6397： | 1 |
| 20 | Incidence of extensor pollicis longus tendon rupture after nondisplaced distal radius fractures 显示文摘 | ROTH K M BLAZAR P E EARP B E | 2012 | The Journal of Hand Surgery2012，37，5： | 1 |
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