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| 1 | 麻疹的分子流行病学与监测显示文摘 | Paul Rota 许文波 | 2002 | 中国计划免疫2002，8，3： | 9 |
| 2 | Characterization of a novel coronavirus associated with severe acute respiratory syndrome显示文摘 | Rota PA Oberste MS Monroe SS | | 0，，： | 6 |
| 3 | Risk factors for resistance to ceftriaxone and its impact on mortality in community, healthcare and nosocomial spontaneous bacterial peritonitis显示文摘 | Xavier Ariza José Castellote Jaime Lora-Tamayo Anna Girbau Sílvia Salord Rosa Rota Javier Ariza Xavier Xiol | 2011 | Journal of Hepatology2011，，4： | 5 |
| 4 | Constipation,deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alphasynucleinopathy显示文摘Background:Gastrointestinal dysfunction can affect Parkinson’s disease(PD)patients long before the onset of motor symptoms.However,little is known about the relationship between gastrointestinal abnormalities and the development of PD.Contrary to other animal models,the human A53T alpha-synuclein(αS)transgenic mice,Line G2–3,developsαS-driven neurological and motor impairments after 9 months of age,displaying a long presymptomatic phase free of central nervous system(CNS)dysfunction.Methods:To determine whether this line can be suitable to study constipation as it occurs in prodromal PD,gastrointestinal functionality was assessed in young mice through a multidisciplinary approach,based on behavioral and biochemical analysis combined with electrophysiological recordings of mouse intestinal preparations.Results:We found that the A53TαS mice display remarkable signs of gastrointestinal dysfunction that precede motor abnormalities andαS pathology in the CNS by at least 6 months.YoungαS mice show a drastic delay in food transit along the gastrointestinal tract,of almost 2 h in 3 months old mice that increased to more than 3 h at 6 months.Such impairment was associated with abnormal formation of stools that resulted in less abundant but longer pellets excreted,suggesting a deficit in the intestinal peristalsis.In agreement with this,electrically evoked contractions of the colon,but not of the ileum,showed a reduced motor response in both longitudinal and circular muscle layers inαS mice already at 3 months of age,that was mainly due to an impaired cholinergic transmission of the underlying enteric nervous system.Interestingly,the presence of insoluble and aggregatedαS was found in enteric neurons in both myenteric and submucosal plexi only in the colon of 3 months oldαS mice,but not in the small intestine,and exacerbated with age,mimicking the increase in transit delay and the contraction deficit showed by behavioral and electrical recordings data.Conclusions:Gastrointestinal dysfunction in A53TαS mice represents an early sign ofαS-driven pathology without concomitant CNS involvement.We believe that this model can be very useful to study disease-modifying strategies that could extend the prodromal phase of PD and haltαS pathology from reaching the brain. | Lucia Rota Carolina Pellegrini Laura Benvenuti Luca Antonioli Matteo Fornai Corrado Blandizzi Antonino Cattaneo Emanuela Colla | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 5 | Thyroid carcinoma showing thymus-like differentiation: Case presentation of a young man显示文摘Ectopic thymic tissue can be present in the thyroid gland and a carcinoma showing thymus-like differentiation(CASTLE) may arise from such tissue. We are reported the case of a 26-year-old man with CASTLE, with cervical subcutaneous nodules relapse, who showed a good response to treatment with surgery, chemotherapy and radiotherapy. The problematic aspect of this case was the diagnosis; only on review were we able to make a final diagnosis. CASTLE is a very rare neoplasm. It is important to differentiate this cancer from others tumors such as primary or metastatic squamous cell carcinoma of the head and neck or squamous cell thyroid carcinoma, because the therapy and prognosis are different.Diagnosis is complicated and requires careful histological analysis(CD5- and P63-positive with presence of Hassall's corpuscles); unfortunately there is no gold standard treatment so, in this case, we administered a sandwich of chemotherapy and radiotherapy. | Chiara Abeni Chiara Ogliosi Luigina Rota Paola Bertocchi Alessandra Huscher Giordano Savelli Mariano Lombardi Alberto Zaniboni | 2014 | World Journal of Clinical Oncology2014，5，5： | 5 |
| 6 | Subcellular localization of alpha-synuclein aggregates and their interaction with membranes显示文摘For more than a decade numerous evidence has been reported on the mechanisms of toxicity of α-synuclein(αS) oligomers and aggregates in α-synucleinopathies.These species were thought to form freely in the cytoplasm but recent reports of αS multimer conformations when bound to synaptic vesicles in physiological conditions,have raised the question about where αS aggregation initiates.In this review we focus on recent literature regarding the impact on membrane binding and subcellular localization of αS toxic species to understand how regular cellular function of αS contributes to pathology.Notably αS has been reported to mainly associate with specific membranes in neurons such as those of synaptic vesicles,ER/Golgi and the mitochondria,while toxic species of αS have been shown to inhibit,among others,neurotransmission,protein trafficking and mitochondrial function.Strategies interfering with αS membrane binding have shown to improve αS-driven toxicity in worms and in mice.Thus,a selective membrane binding that would result in a specific subcellular localization could be the key to understand how aggregation and pathology evolves,pointing out to αS functions that are primarily affected before onset of irreversible damage. | Fabiana Miraglia Alessio Ricci Lucia Rota Emanuela Colla | 2018 | Neural Regeneration Research2018，13，7： | 4 |
| 7 | Entrapment neuropathies in diabetes mellitus显示文摘Neuropathy is a common complication of diabetes mellitus(DM) with a wide clinical spectrum that encompasses generalized to focal and multifocal forms. Entrapment neuropathies(EN), which are focal forms, are so frequent at any stage of the diabetic disease, that they may be considered a neurophysiological hallmarkof peripheral nerve involvement in DM. Indeed, EN may be the earliest neurophysiological abnormalities in DM,particularly in the upper limbs, even in the absence of a generalized polyneuropathy, or it may be superimposed on a generalized diabetic neuropathy. This remarkable frequency of EN in diabetes is underlain by a peculiar pathophysiological background. Due to the metabolic alterations consequent to abnormal glucose metabolism,the peripheral nerves show both functional impairment and structural changes, even in the preclinical stage,making them more prone to entrapment in anatomically constrained channels. This review discusses the most common and relevant EN encountered in diabetic patient in their epidemiological, pathophysiological and diagnostic features. | Eugenia Rota Nicola Morelli | 2016 | World Journal of Diabetes2016，7，17： | 3 |
| 8 | Hepatitis B-related events in autologous hematopoietic stem cell transplantation recipients显示文摘AIM: To investigate the frequency of occult hepatitis B, the clinical course of hepatitis B virus (HBV) reactivation and reverse seroconversion and associated risk factors in autologous hematopoietic stem cell transplantation (HSCT) recipients. METHODS: This study was conducted in 90 patients undergoing autologous HSCT. Occult HBV infection was investigated by HBV-DNA analysis prior to transplantation, while HBV serology and liver function tests were screened prior to and serially after transplantation. HBV-related events including reverse seroconversion and reactivation were recorded in all patients. RESULTS: None of the patients had occult HBV prior to transplantation. Six (6.7%) patients were positivefor HBV surface antigen (HBsAg) prior to transplantation and received lamivudine prophylaxis; they did not develop HBV reactivation after transplantation. Clinical HBV infection emerged in three patients after transplantation who had negative HBV-DNA prior to HSCT. Two of these three patients had HBV reactivation while one patient developed acute hepatitis B. Three patients had anti-HBc as the sole hepatitis B-related antibody prior to transplantation, two of whom developed hepatitis B reactivation while none of the patients with antibody to HBV surface antigen (anti-HBs) did so. The 14 anti-HBs-and/or anti-HBc-positive patients among the 90 HSCT recipients experienced either persistent (8 patients) or transient (6 patients) disappearance of anti-HBs and/or anti-HBc. HBsAg seroconversion and clinical hepatitis did not develop in these patients. Female gender and multiple myeloma emerged as risk factors for loss of antibody in regression analysis (P < 0.05). CONCLUSION: Anti-HBc as the sole HBV marker seems to be a risk factor for reactivation after autologous HSCT. Lamivudine prophylaxis in HbsAg-positive patients continues to be effective. | zcan eneli Zübeyde Nur zkurt Kadir Acar Seyyal Rota Sahika Zeynep Aki Zeynep Arzu Yegin Münci Yagci Seren zenirler Gülsan Türkz Sucak | 2010 | World Journal of Gastroenterology2010，16，14： | 3 |
| 9 | Serious drug-induced liver disease secondary to ezetimibe显示文摘Ezetimibe is the f irst member of a new family of lipid- lowering drugs that inhibits uptake of dietary and bili- ary cholesterol. It was approved by the FDA in 2002 for hypercholesterolemia alone or in combination with statins. Its use has been spreading over the last years. Ezetimibe was considered a safe drug. We report a case of a woman who developed a serious hepatocellular drug-induced liver disease after 4 mo therapy with 10 mg daily of ezetimibe. After withdrawal of the drug, the patient recovered slowly. Ezetimibe may produce seri- ous toxic hepatitis and prompt withdrawal is mandatory in case of a signif icant abnormality in liver testing after beginning or during treatment with ezetimibe. | José Castellote Javier Ariza Rosa Rota Anna Girbau Xavier Xiol | 2008 | World Journal of Gastroenterology2008，14，32： | 3 |
| 10 | DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate显示文摘 | Mary Premenko-Lanier Paul A Rota Gary Rhodes David Verhoeven Dan H Barouch Nicholas W Lerche Norman L Letvin William J Bellini Michael B McChesney | 2003 | Virology2003，，1： | 2 |
| 11 | Data mining for simple sequence repeats in expressed sequence tags from barley, maize, rice, sorghum and wheat显示文摘 | Ramesh V. Kantety Mauricio La Rota David E. Matthews Mark E. Sorrells | 2002 | Plant Molecular Biology2002，，5： | 2 |
| 12 | Antimicrobial activity and chemical composition of Thymus vulgaris , Thymus zygis and Thymus hyemalis essential oils显示文摘 | María C. Rota Antonio Herrera Rosa M. Martínez Jose A. Sotomayor María J. Jordán | 2007 | Food Control2007，，7： | 2 |
| 13 | Cesarean Scar Ectopic Pregnancies: Etiology, Diagnosis, and Management 显示文摘 | Rotas M A Haberman S Levgur M | 2006 | Obstet Gynecol2006，107，6： | 1 |
| 14 | Comparative DNA sequence analysis of wheat and rice genomes显示文摘 | La Rota M Bermudez-Kandianis C E Greene R A Kantety R | 2003 | Genome Res2003，13，： | 1 |
| 15 | Nonrandom distribution and frequencies of genomie and EST - derived mierosatellite markers in flee, wheat, and barley 显示文摘 | ROTA L M KANTETY R V YU J K | 2005 | BMC Genomics2005，6，： | 1 |
| 16 | Cesarean scar ectopicpregnancies:etiology,diagnosis,and management显示文摘 | Rotas MA Haberman S Levgur M | 2006 | Ob-stet Gynecol2006，107，6： | 1 |
| 17 | Characterization of a novel coronavirus associated with severe acute respiratory syndrome 显示文摘 | Rota PA Oberste MS Monroe SS | 2003 | Science2003，300，5624： | 1 |
| 18 | Genetic diversity of wild-type measles viruses: Implications for global measles elimination programs显示文摘 | Bellini W J Rota P A | 1998 | Emerg Infect Dis1998，4，： | 1 |
| 19 | New genetic group of measles virus isolated in the People's Republic of China显示文摘 | Wen-B X Jennifer A T Rota T | 1998 | Virus Rese1998，54，： | 1 |
| 20 | Tobacco smoke in the development and therapy of periodondal disease:progress and questions显示文摘 | Rota MT Poggi P Baratta L | 1999 | Bull Group Int Rech Sci Stomatol Odontol1999，41，4： | 1 |
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