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| 1 | Optimal timing and route of nutritional support after esophagectomy: A review of the literature显示文摘Some controversy surrounds the postoperative feeding regimen utilized in patients who undergo esophagectomy.Variation in practices during the perioperative period exists including the type of nutrition started,the delivery route,and its timing.Adequate nutrition is essential for this patient population as these patients often present with weight loss and have altered eating patterns after surgery,which can affect their ability to regain or maintain weight.Methods of feeding after an esophagectomy include total parenteral nutrition,nasoduodenal/nasojejunal tube feeding,jejunostomy tube feeding,and oral feeding.Recent evidence suggests that early oral feeding is associated with shorter LOS,faster return of bowel function,and improved quality of life.Enhanced recovery pathways after surgery pathways after esophagectomy with a component of early oral feeding also seem to be safe,feasible,and cost-effective,albeit with limited data.However,data on anastomotic leaks is mixed,and some studies suggest that the incidence of leaks may be higher with early oral feeding.This risk of anastomotic leak with early feeding may be heavily modulated by surgical approach.No definitive data is currently available to definitively answer this question,and further studies should look at how these early feeding regimens vary by surgical technique.This review aims to discuss the existing literature on the optimal route and timing of feeding after esophagectomy. | Richard Zheng Courtney L Devin Michael J Pucci Adam C Berger Ernest L Rosato Francesco Palazzo | 2019 | World Journal of Gastroenterology2019，25，31： | 11 |
| 2 | Clinical features and natural history of cryptogenic cirrhosis compared to hepatitis C virus-related cirrhosis显示文摘AIM To characterize natural history of cryptogenic cirrhosis(CC) and compare its clinical features and outcomes to those of hepatitis C virus(HCV)-related cirrhosis.METHODS A prospective cohort of 102 consecutive patients at their first diagnosis of CC were enrolled in this study. The clinical data and outcomes were compared to an ageand Child-pugh class-matched cohort of 110 patients with HCV-related cirrhosis. Diagnosis of cirrhosis was based on compatible clinical and laboratory parameters, ultrasound/endoscopic parameters and, whenever possible, on histological grounds and transient elastography. All cases of cirrhosis without a definite etiology were enrolled in the CC group. The parameters assessed were:(1) severity of liver disease at the time of first diagnosis;(2) liver decompensation during follow-up;(3) hepatocellular carcinoma(HCC);(4) orthotopic liver transplantation; and(5) death. The independent associated factors were evaluated by multiple logistic regression analysis, and survival and its determinants by the Kaplan-Meier model, log-rank test and Cox regression.RESULTS At the first observation, median age was 66 and 65 years and male gender was 36% and 58% for CC and HCV cirrhosis, respectively. CC showed Child-pugh class A/B/C of 47%/31%/22%, respectively. Compared to HCV cirrhosis, CC exhibited a significantly higher prevalence of metabolic syndrome(12% vs 54%, respectively), overweight/obesity, high BMI, impaired glucose tolerance, high blood pressure, dyslipidemia, hyperuricemia, cardiovascular diseases, extrahepatic cancer, and gallstones. Over a median period of 42 mo of follow-up, liver decompensation, HCC development and death for CC and HCV-related cirrhosis were 60.8%, and 54.4%, 16.7% and 17.2%, 39.2% and 30%, respectively. The median survival was 60 mo for CC. Independent predictors of death were age and Childpugh class at diagnosis. CC showed an approximately twofold higher incidence of HCC in Child-pugh class A.CONCLUSION Undiagnosed nonalcoholic fatty liver disease has an etiologic role in CC that is associated with a poor prognosis, early HCC development, high risk of cardiovascular disease and extrahepatic cancer. | Luca Rinaldi Fabio Nascimbeni Mauro Giordano Chiara Masetti Barbara Guerrera Annalisa Amelia Maria Chiara Fascione Stefano Ballestri Dante Romagnoli Rosa Zampino Riccardo Nevola Enrica Baldelli Natalina Iuliano Valerio Rosato Amedeo Lonardo Luigi Elio Adinolfi | 2017 | World Journal of Gastroenterology2017，23，8： | 5 |
| 3 | Co-encapsulation of curcumin and doxorubicin in albumin nanoparticles blocks the adaptive treatment tolerance of cancer cells显示文摘The adaptive treatment tolerance (ATT) of cancer cells is the main encumbrance to cancer chemotherapy. A potential solution to this problem is to treat cancer cells with multiple drugs using nanoparticles (NPs). In this study, we tested the co-administration of curcumin (Cur) and doxorubicin (Dox) to MCF-7 resistant breast cancer cells to block the ATTand elicit efficient cell killing. Drugs were co-administered to cells both sequentially and simultaneously. Sequential drug co-administration was carried out by pre-treating the cells with albumin nanoparticles (ANPs) loaded w让h Cur (Cur@ANPs) followed by treatment with Dox-loaded ANPs (Dox@ANPs). Simultaneous drug co-administration was carried out by treating the cells with ANPs loaded with both the drugs (Cur/Dox@ANPs). We found that the simultaneous drug co-administration led to a greater intra-cellular accumulation of Dox and cell killing with respect to the sequential drug co-administration. However;the simultaneous drug co-administration led to a lower intracellular accumulation of Cur with respect to the sequential drug co-administration. We showed that this result was due to the aggregation and entrapment of Cur in the lysosomes as soon as it was released from Cur@ANPs, a phenomenon called lysosomotropism. In contrast, the simultaneous release of Dox and Cur from Cur/Dox@ANPs into the lysosomes led to lysosomal pH elevation, which, in turn, avoided Cur aggregation, led to lysosome swelling and drug release in the cytosol, and finally provoked efficient cell killing. Our study shed the light on the molecular processes driving the therapeutic effects of anti-cancer drugs co-administered to cancer cells in different manners. | Seyed Mohammad Motevalli Ahmed Shaker Eltahan Lu Liu Andrea Magrini Nicola Rosato Weisheng Guo Massimo Bottini Xing-Jie Liang | 2019 | Biophysics Reports2019，5，1： | 3 |
| 4 | Drosophila melanogaster as a model system of aluminum toxicity and aging显示文摘这研究的目的是在模型 organismDrosophila melanogaster 上调查铝(艾尔) 的有毒的效果。学习特别在休息和活动在水果苍蝇的发展,寿命,和生理节奏的节奏担心铝的效果。苍蝇在饲养媒介从 40 ~ 280 mg/kg 在集中暴露于铝或苍蝇在控制媒介上被饲养。而且,昆虫的寿命在媒介暴露了艾尔的 40, 120,或 240 mg/kg 到铝包含仅仅在他们的幼虫的发展期间,在整个生命周期期间并且仅仅在他们的成年人,生活被测试。检查铝和老化原因是否在 D 变化。melanogaster 行为,在不同年龄的苍蝇的运动活动被记录。结果证明那铝在在在高耸的媒介的 160 mg/kg 上面的集中是有毒的。取决于艾尔集中和暴露的时间,苍蝇的寿命被弄短。在中间的集中(120 mg/kg ) ,然而,艾尔在增加他们运动活动的寿命和水平的男性上有刺激效果。在更高的集中,铝暴露增加了或减少 D 的运动活动的水平。取决于苍蝇的年龄的 melanogaster。另外,在在铝上饲养的最旧的昆虫补充了媒介,在在艾尔的最高的集中上饲养的中间的苍蝇,活动的每日的节奏被破坏。 | Ewelina Kijak Ezio Rosato Katarzyna Knapczyk Elzbieta Pyza | 2014 | Insect Science2014，21，2： | 2 |
| 5 | Quantitation of mecA transcription in oxacillin-resistant Staphylococcus aureus clinical isolates显示文摘 | Rosato AE Craig WA Archer GL | 2003 | J Bacteriol2003，185，11： | 1 |
| 6 | Staphylococcus aureus as an infectious agent: overview of biochemistry and molecular genetics of its pathogenicity 显示文摘 | PLATA K ROSATO AE WEGRZYN G | 2009 | Acta Biochim Pol2009，56，： | 1 |
| 7 | Formation of an active elective barrier at Al/semiconductor interface : a novel approach in corrosion prevention 显示文摘 | Jain F C Rosato J J Mani G | 1986 | Corrosion1986，42，： | 1 |
| 8 | Long -term results of combined modality treatment with ^125I inplantation for carcinoma of pancreas显示文摘 | Mobiuddin M Rosato F Darbot D | 1992 | Int J Radiat Oncol Bio phys1992，23，2： | 1 |
| 9 | Latent Class Analysis: A Method for Captu- ring Heterogeneity 显示文摘 | Rosato NS Baer JC | 2012 | Soc Work Res2012，36，1： | 1 |
| 10 | Extensive clinical experi- ence : relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism显示文摘 | Carmina E Rosato F Janni A | 2006 | J Clin Endocrinol Metab2006，91，1： | 1 |
| 11 | Long-term results of combined modality treatment with 1-125 implantation for carcinoma of the pancreas 显示文摘 | MOHIUDDIN M ROSATO F BARBOT D | 1992 | Int J Radiat Oncol Biol Phys1992，23，2： | 1 |
| 12 | Thermodynamical and structural properties of fcc transition metals using a simple tight-binding model显示文摘 | Rosato V Massimo C Legrand B | 1989 | Philos Mag A1989，59，2： | 1 |
| 13 | Survivin in esophageal cancer:An aceulate prognostic marker for squamous cell carcinoma but not adenocarcinoma显示文摘 | Rosato A Pivetta M Parenti A | 2006 | Cancer2006，119，7： | 1 |
| 14 | Thermodynamical and structural properties of fcc transition metals using a simple tight-binding model 显示文摘 | Rosato V Guillope M Legrand B | 1989 | Philosophical Magazine1989，59，： | 1 |
| 15 | Tight-binding potentials for transition metals and alloys显示文摘 | Fabrizio Cleri Vittorio Rosato | 1993 | Physical Review B1993，48，1： | 1 |
| 16 | Cisplatin ototoxicity and otoprotection with sodium salicylate显示文摘 | Hyppolito MA dc Oliveira JA Rosato M | 2006 | Eur Arch Otorhinolarygol2006，263，9： | 1 |
| 17 | Anatomic study of the pelvis in carcinoma of the uterine cervix as mimed to the box technique显示文摘 | Zunino S Rosato O Imeino S | 1999 | Int J Radiat Oneol Biol PhvS1999，44，1： | 1 |
| 18 | Modelling interdependent infrastructures using interacting dynamical models显示文摘 | Rosato V Issacharoff L Tiricco F | 2008 | International Journal of Critical Infrastructures2008，4，12： | 1 |
| 19 | The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 显示文摘 | ROSATO R R ALMENARA J A GRANT S | 2003 | Cancer Res2003，63，13： | 1 |
| 20 | Modelling interdependent infrastructures using interacting dynamical models 显示文摘 | ROSATO V ISSACHAROFF L TIRITICCO F | 2008 | International Journal of Critical Infrastructures2008，4，12： | 1 |
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