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| 1 | 二氢杨梅素对神经退行性果蝇的作用显示文摘目的:研究二氢杨梅素(DMY)对铝离子诱导的神经退行性疾病(ND)果蝇的作用。方法:通过行为学检测喂食不同DMY浓度果蝇的寿命及爬行结果,分析DMY对铝暴果蝇神经退行性变的作用。结果:喂食含有DMY的果蝇寿命与爬行情况和正常对照组及加铝组均有显著差异。寿命实验中正常对照组、ND组、ND+DMY(1 mmol/L)组、ND+DMY(5mmol/L)组、ND+DMY(10mmol/L)组、ND+DMY(15mmol/L)组,平均寿命分别为21.3d、4.2d、7.6d、8.9d、5.4d、3.6d,其中正常对照组与其他各组比较,差异均有统计学意义,ND组与ND+DMY(5mmol/L)加药组比较,差异有统计学意义,爬行实验也同样反映了DMY组与模型组的差异。结论:DMY对铝暴果蝇神经退行性变具有一定的保护作用,提示DMY可能对神经退行性疾病的预防和治疗具有一定的意义。 | 应曜宇 宋远见 胡昕迪 明福 沈玉 王玉兰 | 2018 | 解剖学杂志2018，41，1： | 2 |
| 2 | Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds显示文摘Exposure to some toxic compounds causes structural and behavioral anomalies associated with the neurons in the later stage of life.Those toxic compounds are termed as a neurotoxicant,which can be a physical factor,a toxin,an infection,radiation,or maybe a drug.The incongruities caused due to a neurotoxicant further depend on the toxicity of the compound.More importantly,the neurotoxicity of the compound is associated with the concentration and the time point of exposure.The neurodevelopmental defect appears depending on the toxicity of the compound.A neurodevelopmental defect may be associated with a delay in developmental time,defective growth,structural abnormality of many organs,including sensory organs,behavioral abnormalities,or death in the fetus stage.Numerous model organisms are employed to assess the effect of neurotoxicants.The current review summarizes several methods used to check the effect of neurotoxicant and their effect using the model organism Drosophila melanogaster. | MONALISA MISHRA PUNYATOYA PANDA BEDANTA KUMAR BARIK AMRITA MONDAL MRUTUNJAYA PANDA | 2023 | BIOCELL2023，47，1： | 0 |
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