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| 1 | New perspectives in the treatment of advanced or metastatic gastric cancer显示文摘Metastatic gastric cancer remains an incurable disease,with a relative 5-year survival rate of 7%-27%.Chemotherapy,which improves overall survival(OS) and quality of life,is the main treatment option.Metaanalysis has demonstrated that the best survival results obtained in earlier randomized studies were achieved with three-drug regimens containing a fluoropyrimidine,an anthracycline,and cisplatin(ECF).Although there has been little progress in improving median OS times beyond the 9-mo plateau achievable with the standard regimens,the availability of newer agents has provided some measure of optimism.A number of new combinations incorporating docetaxel,oxaliplatin,capecitabine,and S-1 have been explored in randomized trials.Some combinations,such as epirubicin-oxaliplatin-capecitabine,have been shown to be as effective as(or perhaps more effective than) ECF,and promising early data have been derived for S-1 in combination with cisplatin.One factor that might contribute to extending median OS is the advancement whenever possible to second-line cytotoxic treatments.However,the biggest hope for signif icant survival advances in the near future would be the combination of new targeted biological agents with existing chemotherapy f irst-line regimens. | Gerardo Rosati Domenica Ferrara Luigi Manzione | 2009 | World Journal of Gastroenterology2009，15，22： | 41 |
| 2 | Introducing an enhanced recovery after surgery program in colorectal surgery:A single center experience显示文摘AIM:To study the implementation of an enhanced recovery after surgery(ERAS)program at a large University Hospital from'pilot study'to'standard of care'.METHODS:The study was designed as a prospective single centre cohort study.A prospective evaluation of compliance to a protocol based on full application of all ERAS principles,through the progressive steps of its implementation,was performed.Results achieved in the initial pilot study conducted by a dedicated team(n=47)were compared to those achieved in the shared protocol phase(n=143)three years later.Outcomes were length of postoperative hospital stay,readmission rate,compliance to the protocol and morbidity.Primary endpoint was the description of the results and the identification of critical issues of large scale implementation of an ERAS program in colorectal surgery emerged in the experience of a single center.Secondary endpoint was the identification of interventions that have been proven to be effective for facilitating the transition from traditional care pathways to a multimodal management protocol according to ERAS principles in colorectal surgery at a single center.RESULTS:During the initial pilot study(March 2009 to December 2010;47 patients)conducted by a dedicated multidisciplinary team,compliance to the items of ERAS protocol was 93%,with a median length of hospital stay(LOS)of 3 d.Early anastomotic fistulas were observed in 2 cases(4.2%),which required reoperation(Clavien-Dindo gradeⅢb).None of the patients had been discharged before the onset of the complication,which could therefore receive prompt treatment.There were also four(8.5%)minor complications(ClavienDindo gradeⅡ).Thirty days readmission rate was 4%.Perioperative mortality was nil.After implementation of the protocol throughout the Hospital in unselected patients(May 2012 to December 2012;147 patients)compliance was 74%,with a median LOS of 6 d.Early anastomotic fistulas were observed in 11 cases(7.7%),5(3.5%)of which required reoperation(Clavien-Dindo gradeⅢb).Two early anastomotic fistulas were treated by radiologic/endoscopic manoeuvres and 4 were treated conservatively.There were also 36(25.2%)minor complications,21(14.7%)of which were Clavien-Dindo gradeⅡand 15(10.5%)of which were Clavien-Dindo gradeⅠ.Only two patients whose course was adversely affected by the development of an anastomotic leak had been discharged before the onset of the complication itself,requiring readmission.Readmission rate within 30 d was 4%.Perioperative mortality was 1%.CONCLUSION:Our results confirm that introduction of an ERAS protocol for colorectal surgery allows quickerpostoperative recovery and shortens the length of stay compared to historical series. | Stefano Bona Mattia Molteni Riccardo Rosati Ugo Elmore Pietro Bagnoli Roberta Monzani Monica Caravaca Marco Montorsi | 2014 | World Journal of Gastroenterology2014，20，46： | 30 |
| 3 | Amino acids 89-96 of Salmonella typhimunum Tlagell=n represent the major domain responsible for TLR5-independent adjuvanticity in the humoral immune response显示文摘 | Lei Zhang Zhiming Pan Xilong Kang Yun Yang Heekap Kang Na Zhang James M Rosati Xinan Jiao | 2015 | Cellular & Molecular Immunology2015，12，5： | 6 |
| 4 | 全球国际收支失衡:欧洲的观点显示文摘 | Alan Ahearne Klaus Regling In Jun Kim Dariusz Rosati 施建淮 | 2006 | 国际经济评论2006，，5： | 5 |
| 5 | Role of chemotherapy and novel biological agents in the treatment of elderly patients with colorectal cancer显示文摘Patients older than 65 years are the fastest growing segment of the cancer population. It is estimated that within 20 years over 75% of cases and 85% of deaths from colorectal cancer (CRC) will be in this setting. Concerns about cancer treatment in the elderly relate to comorbidities, which increase proportionally with age, physiological changes associated with aging which may influence drug metabolism and toxicity, and diminishing life expectancy, which particularly impacts decisions surrounding the benefits of adjuvant therapies. Over the last 10 years, significant improvements in the treatment of advanced CRC with combination therapy have been made. The randomized trials which have defined these improvements did not exclude elderly patients. However, the median age of patients in these trials has generally been approximately 60 years. Thus, it appears that some degree of selection is involved with younger and presumably fitter patients being the subjects in most of the pivotal trials. The availability of new molecularly targeted agents and newly improved existing agents has expanded the range of treatment options available. This variety gives greater flexibility in dealing with different subsets of patients, such as the elderly. However, some fit elderly patients seem to tolerate combination therapy reasonably well, while studies on unfit elderly subjects are needed. | Gerardo Rosati Domenico Bilancia | 2008 | World Journal of Gastroenterology2008，14，12： | 4 |
| 6 | Colorectal cancer screening from 45 years of age: Thesis, antithesis and synthesis显示文摘Colorectal cancer incidence and mortality in patients younger than 50 years are increasing, but screening before the age of 50 is not offered in Europe. Advancedstage diagnosis and mortality from colorectal cancer before 50 years of age are increasing. This is not a detection-bias effect;it is a real issue affecting the entire population. Three independent computational models indicate that screening from 45 years of age would yield a better balance of benefits and risks than the current start at 50 years of age. Experimental data support these predictions in a sex- and race-independent manner. Earlier screening is seemingly affordable, with minimal impediments to providing younger adults with colonoscopy. Indeed, the American Cancer Society has already started to recommend screening from 45 years of age in the United States. Implementing early screening is a societal and public health problem. The three independent computational models that suggested earlier screening were criticized for assuming perfect compliance. Guidelines and recommendations should be derived from well-collected and reproducible data, and not from mathematical predictions. In the era of personalized medicine, screening decisions might not be based solely on age, and sophisticated prediction software may better guide screening. Moreover, early screening might divert resources away from older individuals with greater biological risks. Finally, it is still unknown whether early colorectal cancer is part of a continuum of disease or a biologically distinct disease and, as such, it might not benefit from screening at all. The increase in early-onset colorectal cancer incidence and mortality demonstrates an obligation to take actions. Earlier screening would save lives, and starting at the age of 45 years may be a robust screening option. | Alessandro Mannucci Raffaella Alessia Zuppardo Riccardo Rosati Milena Di Leo José Perea Giulia Martina Cavestro | 2019 | World Journal of Gastroenterology2019，25，21： | 2 |
| 7 | The occlusal plane in the facial context:inter-operator repeatability of a new three-dimensional method显示文摘The repeatability of a non-invasive digital protocol proposed to evaluate the three-dimensional(3D) position of the occlusal plane in the face is assessed.Dental virtual models and soft tissue facial morphology of 20 adult subjects were digitally integrated using a 3D stereophotogrammetric imaging system.The digital 3D coordinates of facial and dental landmarks were obtained by two different operators.Camper's(facial) and occlusal(dental) planes were individuated,and their 3D relationships were measured.The repeatability of the protocol was investigated and showed no significant differences in repeated digitizations.The angle between occlusal and Camper's planes was smaller than 26 in the frontal and horizontal projections.In the sagittal projection,the angle was observed to be,on average,4.9 6.The determined occlusal plane pitch,roll and yaw values show good agreement with previously published data obtained by different protocols.The current non-invasive method was repeatable,without inter-operator differences and can facilitate assessment of healthy subjects. | Riccardo Rosati Alberto Rossetti Marcio De Menezes Virgilio F Ferrario Chiarella Sforza | 2012 | International Journal of Oral Science2012，4，1： | 2 |
| 8 | Laparoscopic Rectal Resection for Cancer: Effects of Conversion on Short-Term Outcome and Survival显示文摘 | Matteo Rottoli Stefano Bona Riccardo Rosati Ugo Elmore Paolo P. Bianchi Antonino Spinelli Cristina Bartolucci Marco Montorsi | 2009 | Annals of Surgical Oncology2009，，： | 2 |
| 9 | Prevention of Peritoneal Metastases from Colon Cancer in High-Risk Patients: Preliminary Results of Surgery plus Prophylactic HIPEC显示文摘 | Paolo Sammartino Simone Sibio Daniele Biacchi Maurizio Cardi Fabio Accarpio Pietro Mingazzini Maria Sofia Rosati Tommaso Cornali Angelo Di Giorgio Paul H. Sugarbaker | 2012 | Gastroenterology Research and Practice2012，，： | 2 |
| 10 | Elderly patients with advanced colorectal cancer: which therapy is the safest? 显示文摘 | Rosati G | 2005 | Expert Opin Drug Saf2005，4，： | 1 |
| 11 | Growth,feed conversion,protein utilization,and sensory evaluation of nile tilapia fed diets containing corn gluten meal,full-fat soy,and synthetic amino acids显示文摘 | Wu Y V Rosati R Warner K | 2000 | J Aquat Food Prod Technol2000，9，： | 1 |
| 12 | JNK is constitutively active in mantle cell lymphoma: Cell cycle deregulation and polyploidy by JNK inhibitor SP600125 显示文摘 | Wang M Atayar C Rosati S | 2009 | J Pathol2009，218，1： | 1 |
| 13 | Bond and splitting in bar pull-out: Behavioral laws and concrete-cover role 显示文摘 | Gambarova P G Rosati G P | 1997 | Magazine of Concrete Research1997，49，179： | 1 |
| 14 | Molecular characterization of the anthocyanin synthase gene in Forsythia x int-ermeo:'a reveals organ-specific expression during flower development显示文摘 | Rosati C Cadic A Duron M | 1999 | Plant Science1999，149，： | 1 |
| 15 | Long-term outcome of hyst- eroscopic endometrial ablation without endometrial preparation 显示文摘 | Rosati M Vigone A Capobianco F | 2008 | Eur J Obstet Gynecol Reprod Bio12008，138，2： | 1 |
| 16 | Robotic-assisted rehabilitation of the upper limb after acute stroke显示文摘 | Masiero S Celia A Rosati G | 2007 | Arch Phys Med Rehabil2007，88，2： | 1 |
| 17 | Copyright: Google Books' Library Project is fair use显示文摘 | Eleonora Rosati | 2014 | Journal of Intellectual Property Law & Practice2014，9，2： | 1 |
| 18 | Preliminary investigation of corneal wavefront aberra- tion following femtosecond laser clear corneal incision for cata- ract surgery 显示文摘 | Serrao S Lombardo G Schiano-Lomoriello D Rosati M Lom- bardo M | 2014 | Eur J Ophthalmol2014，24，6： | 1 |
| 19 | Acute traumatic injury of the diaphragm显示文摘 | Rosati C | 2008 | Chest Surg Clin North Am2008，8，2： | 1 |
| 20 | Epilepsy in cerebral glioma:timing of appearance and histological correlations显示文摘 | Rosati A Tomassini A Pollo B | 2009 | J Neurooncol2009，93，3： | 1 |
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