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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Balancing cell adhesion and Wnt signaling,the key role of beta-catenin显示文摘 | Brembeck FH Rosario M Birchmeier W | 2006 | Curr Opin Genet Dev2006，16，1： | 1 |
| 3 | Comparison of nitrogen, phosphorus and potassium utilization efficiency in maize/mung bean intercropping显示文摘 | Chowdhury M K Rosario E L | 1994 | Journal of Agricultural Sciences1994，122，： | 1 |
| 4 | A Bayesian computer vision system for modeling human interactions显示文摘 | Oliver N M Rosario B Pentland A P | 2000 | IEEE Trans PAMI2000，22，8： | 1 |
| 5 | Giardia duodencdis: adhesion-deficient clones have reduced a- bility to establish infection in Mongolian gerbils 显示文摘 | Hemandez-Sanchez J Linan RF Del Rosario Salinas-Tobon M | 2008 | Exp Para- sitol2008，119，3： | 1 |
| 6 | Effect of simultane-ous down-regulation of pectate lyase and endo-(3-l,4-glucanasegenes on strawberry fruit softening显示文摘 | YOUSSEF S M IRAIDA A L^PEZ-ARANDA J M’ RAFAELS VICTORIANO V GIORGIO C ROSARIO B-P FERNAN-DO P-A OUESADA M A MERCADO J A | 2013 | Molecular Breeding2013，31，： | 1 |
| 7 | Muhimodal management of lateral epi- condylatgia in rock climbers:a prospective case series显示文摘 | GONZALEZ-IGLESIAS J CLELAND J A DEL ROSARIO GU- TIERREZ-VEGA M | 2011 | J Manip- ulative Physiol Ther2011，34，9： | 1 |
| 8 | Destruction of the global phase coherence in ultrathin,doubly connected superconducting cylinders显示文摘 | Liu Y Zadorozhny Yu Rosario M M | 2001 | Science2001，294，： | 1 |
| 9 | Enhanced formaldehyde detoxific ation by overexpression of glutathione - dependent formaldehyde dehydmgenase from arabidopsis显示文摘 | Hakima Achkor Maykelis diaz M rosario Fernandez | 2003 | Plant Physiology2003，132，： | 1 |
| 10 | Evaluation of the role of genes encoding for At -pyrroline~5-carboxylate syn- thetase (P5CS) during drought stress in arbuscular mycor- rhizal Glycine max and Lactuca sativa plants 显示文摘 | ROSA P ROSARIO A JUAN M R | 2004 | Physiol Mol Plant P2004，65，4： | 1 |
| 11 | Out-of- pocket medical expenses for inpatient care among bene- ficiaries of the National Health Insurance Program in the Philippines 显示文摘 | Tobe M Stickley A del Rosario RB Jr | 2013 | Health Policy Plan2013，28，5： | 1 |
| 12 | Alcohol and drug use and sexual behaviors placing runaways at risk for HIV infection显示文摘 | Koopman C Rosario M Rotheram - Borus MJ | 1994 | Addict Behav1994，19，： | 1 |
| 13 | Functional Characterization of the Genomic Promoter of Borna Disease Virus (BDV):Implications of 3'-Terminal Sequence Heterogeneity for BDV Persistence显示文摘 | Rosario D Perez M Carlos J | 2005 | J Virol2005，79，10： | 1 |
| 14 | Repletion of the plasma pool of nutrient transport proteins occurs at different rates during the nutritional rehabilitation of severely malnourished children显示文摘 | Morless JF Forrester T Del Rosario M | 1998 | Nutr1998，128，2： | 1 |
| 15 | The changing pattern of mor-tality and morbidity from radical cystectomy显示文摘 | Rosario DJ Becker M Anderson JB | 2000 | BJU Int2000，85，4： | 1 |
| 16 | Multi-Objec- tive Design of Parallel Manipulator Using Global Indices 显示文摘 | LARA-MOLINA F A ROSARIO J M | 2010 | The Open Mechanical Engineering Journal2010，4，： | 1 |
| 17 | Childhood gendernonconformity,bullying victimization,and depressive symptomsacross adolescence and early adulthood:An 11year longitudinal study显示文摘 | ROBERTS AL ROSARIO M SLOPEN N | 2013 | J Am Acad Child Adoles Psychi2013，52，2： | 1 |
| 18 | Prevalence of children with blood pressure measurements exceeding adult cutoffs for optimal blood pres-sure in Germany 显示文摘 | Neuhauser HK Rosario AS Thamm M | 2009 | Eur J Cardiovasc Prey Rehabil2009，16，2： | 1 |
| 19 | Using a Concordancer in Literary Studies显示文摘 | M Rosario C Rodriguez | 1999 | The European English Messenger1999，，： | 1 |
| 20 | Primary and Reversible Pisa Syndrome in Juvenile Normal Pressure Hydrocephalus 显示文摘 | Leon-Sarmiento FE Pradilla G Del Rosario Zambrano M | 2013 | Aeta Neuropsyehiatr2013，25，1： | 1 |
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