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| 1 | Dysregulation of gastric H,K-ATPase by cigarette smoke extract显示文摘AIM:To test whether the expression and activity of H,K-ATPase in parietal cells would be affected by cigarette smoke extract.METHODS: Extracts of cigarette smoke were administered into mice by gastric gavage (5 mg/kg body weight/day) for 3 d or in drinking water for 7 or 14 d. For the latter, each day a mouse consumed 5 mL water containing extracts of two cigarettes, on average. Control littermate mice received only vehicle. To compare the amount of H,K-ATPase in control and smoke-treated mice, the stomach was processed for Western blotting and immunohistochemical analysis using monoclonal antibodies specific for α- or β-subunits of H,K-ATPase. The p-nitrophenylphospatase activity assay was used as a measurement for K-dependent H,K-ATPase activity.RESULTS: Probed transblots showed an increase in the amount of H,K-ATPase in smoke-treated mice which was confirmed by immunohistochemistry and was found to be due to increased amounts of protein per parietal cell rather than an increased parietal cell number. The increase in the amount of H,K-ATPase was associated with an enhancement of its enzymatic activity. K-dependent activity in control and smoke-treated mice was significantly different (respectively, 0.12 μmol/mg vs 0.27 μmol/mg per minute, P<0.05).CONCLUSION: Administration of cigarette smoke extract is associated with an increase in the amount and activity of H,K-ATPase and hence, smokers are susceptible to development of peptic ulcer. | Muna Hammadi Mohamed Adi Rony John Ghalia AK Khoder Sherif M Karam | 2009 | World Journal of Gastroenterology2009，15，32： | 7 |
| 2 | The metabolism of testosterone by the periwinkle ( Littorina littorea ) in vitro and in vivo: Effects of tributyltin显示文摘 | Ronis M J J MasonAZ | 1996 | Mar Environ Res1996，42，： | 1 |
| 3 | Intensive Care Units,Communication between Nurses and Physicians,and Patients' Outcomes显示文摘 | Manojlovich M Antonakos C L Ronis D L | 2009 | Am J Crit Care2009，18，1： | 1 |
| 4 | Identification of multiple rare earth sand associated elements in raw Monazite sands by laser-induced break down spectroscopy 显示文摘 | Abedin K M Haider M Y Rony M A | 2011 | Optics & Laser Technology2011，43，14： | 1 |
| 5 | Lithuanian populations of Phytophthora infestans revealed a high phenotypic diversity显示文摘 | Runno-Paurson E Ronis A Hansen M | 2015 | Journal of Plant Diseases and Protection2015，122，2： | 1 |
| 6 | The Health Consequences of Early Soy Consumption 显示文摘 | Thomas M Badger Martin J J Ronis Reza Hakkak | 2002 | J Nutr2002，132，： | 1 |
| 7 | Induction of cytochrome P4502E1 during chronic ethanol exposure occurs via transcription of the CYP2E1 gene when blood alcohol concentrations are high显示文摘 | BADGER T M HUANG J RONIS M | 1993 | Biochem Biophys Res Commun1993，190，3： | 1 |
| 8 | Potentiation of thioacetamide liver injury in diabetic rat is due to induced CYP2E1显示文摘 | Wang T Shankar K Ronis M | 2000 | J Pharm Exp Ther2000，294，2： | 1 |
| 9 | HPLC- DAD analysis of ketones as their 2,4-dinitrophenylhydrazones in Brazilian sugar-cane spirits and rum显示文摘 | Daniel R Cardoso Sandra M Bettin Roni V Reche et ol | 2003 | Journal of Food Composition and Analysis2003，16，： | 1 |
| 10 | Channel catfish liver monooxygenases:immunological characterization of constitutive cytochromes P450 and the absence of active flavin-containing monooxygenases显示文摘 | Schlenk D Ronis M J J Miranda C L | 1993 | Biochem Pharmacol1993，45，1： | 1 |
| 11 | Effects of 2-methylisoborneol(MIB),and ethanol on the expression and activity of cytochrome P450s from the channel catfish显示文摘 | Schlenk D Ronis M J J Miranda C L | 1995 | J Fish Bio1995，46，2： | 1 |
| 12 | Potentiation of thioacetamide liver injury in diabetic rat is due to induced CYP2E1显示文摘 | Shankar K Ronis M | 2000 | J Pharm Exp Ther2000，294，2： | 1 |
| 13 | Plant regeneration from leaf tissues of four north Dakota genotypes of potato(Solanum Tuberosum L)显示文摘 | Park YD Ronis DH Boe M | 1995 | American potato journal1995，72，6： | 1 |
| 14 | HPLC-DVD analysis of ketoncs as their 2,4-dinitrophenylhydrazones in Brazilian sugar-cane spirits and rum 显示文摘 | DANIEL R CARDOSO SANDRA M BETTIN RONI V RECHE | 2003 | Journal of Food Composition and Analysis2003，16，： | 1 |
| 15 | Expression and distribution of cytochrome P450 enzymes in male rat kidney:effects of ethanol, acetone and dietary conditions 显示文摘 | Ronis M J Huang J Longo V | 1998 | Biochem Pharmacol1998，55，： | 1 |
| 16 | Potentiation of thioacetamide liver injury in diabetic rat is due to induced CYP2E1 显示文摘 | Wang T Shankar K Ronis M | 2000 | J Pharm Exp Ther2000，294，2： | 1 |
| 17 | The metabolism of testosterone by the periwinkel(Littorina littorea)in vitro and in vivo:Effects of tributyltin显示文摘 | Mason A Z | 1996 | Marine Environmental Research1996，42，1： | 1 |
| 18 | Reproductive toxicity and growth effects in rats exposed to lead at different periods during development显示文摘 | Ronis M J Badger T M Shema S J | 1996 | Toxicol appl pharmacol1996，，2： | 1 |
| 19 | The metabolism of testosterone by the periwinkel (Littorina littorea) in vitro and in vivo:Effects of tributyltin显示文摘 | Ronis M J Mason A Z | 1996 | Marine Environmental Research1996，42，1： | 1 |
| 20 | Intensive care units, communication between nurses and physicians and patients' outcomes 显示文摘 | Manojlovich M Antonakos CL Ronis DL | 2009 | Am J Crit Care2009，18，： | 1 |
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