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42篇 您的检索式：作者名="ROMMELAERE J"

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	题名	作者	年代	出处	被引量
1	Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors.	Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler	2008	World Journal of Gastroenterology2008，14，24：	2
2	Terminal regions of the NS-1 protein of the parvovirus minute virus of mice are involved in cytotoxicity and promoter trans inhibition显示文摘	LEGENDRE D ROMMELAERE J	1992	J Virol1992，66，10：	1
3	Modulation of Minute Virus of Mice Cytotoxic Activities through Site-Directed Mutagenesis within the NS Coding Region显示文摘	DAEFFLER L HORLEIN R ROMMELAERE J	2003	J Viral2003，77，12：	1
4	Replicating parvoviruses that target colon cancer cells显示文摘	Malerba M Daeffler L Rommelaere J	2003	J Virol2003，77，：	1
5	Regulation of MVM NS1 by protein kinase C : impact of mutagenesis at consensus phosphorylation sites on replicative functions and cytopathic effects 显示文摘	CORBAU R DUVERGER V ROMMELAERE J	2000	Virology2000，278，：	1
6	Modulation of minute virus of mice cytotoxic activities through site - directed mutagenesis within the NS coding region显示文摘	Daeffler L Horlein R Rommelaere J	2003	J Virol2003，77，12：	1
7	Terminal regions of the NS-1 pro- tein of the parvovirus minute virus of mice are involved in cyto- toxicity and promoter trans inhibition显示文摘	Legendre D Rommelaere J	1992	J Virol1992，66，10：	1
8	NS1 interaction with CKIIα:novel protein complex mediating parvovirus-induced cytotoxicity显示文摘	Nüesch J P Rommelaere J	2006	J Virol2006，80，10：	1
9	Regulation of MVM NS1 by protein kinase C:impact of mutagenesis at consensus phosphorylation sites on replicative functions and cytopathic effects显示文摘	CORBAU R DUVERGER V ROMMELAERE J	2000	Virology2000，278，：	1
10	A viral adaptor protein modulating casein kinase II activity induces cytopathic effects in permissive cells显示文摘	Nuesch J P Rommelaere J	2007	Proc Natl Acad Sci2007，104，12：	1
11	A viral adaptor protein modulating casein kinaseⅡactivity induces cytopathic effects in permissive ceils显示文摘	Naesch J P F Rommelaere J	2007	Proc Natl Acad Sei USA2007，104，12：	1
12	NS1 interaction with CKII alpha: novel protein complex mediating parvovirus-induced cytotoxieity显示文摘	Nuesch J P Rommelaere J	2006	J Virol2006，80，10：	1
13	Modulation of minute virus of mice eytotoxie activities through site-directed mutagenesis within the NS coding region 显示文摘	Daettler L H6rlein R Rommelaere J	2003	J Virol2003，77，12：	1
14	NS1 Interaction with CKIIα:Novel Protein Complex Mediating Parvovirus-Induced Cytotoxicity显示文摘	J(U)RG P F N(U)ESCH J P JEAN ROMMELAERE	2006	J Virol2006，80，：	1
15	Antineoplastic activity of parvoviruses显示文摘	Rommelaere J Cornelis JJ	1991	J Virol Methods1991，33，3：	1
16	Oncolytic potential of rodent parvoviruses for cancer therapy in humans:A brief review显示文摘	Geletneky K Calle MH Rommelaere J	2005	J Vet Med B2005，52，78：	1
17	Terminal regions of the NS-1protein of the parvovirus minute virus of mice are involved in cytotoxicity and promoter trans inhibition显示文摘	LEGENDRE D ROMMELAERE J	1992	J Virol1992，66，10：	1
18	NS1interaction with CKII alpha:novel protein complex mediating parvovirus-induced cytotoxicity显示文摘	Nuesch J P Rommelaere J	2006	J Virol2006，80，10：	1
19	Phosphorylation of the viral nonstructural protein NSlduring MVMp infection of A9 cells显示文摘	Corbau R Salom N Rommelaere J	1999	Virology1999，259，2：	1
20	Unwinding functions of minute virus of mice NS1 protein are modulated specifically by the lambda isoform of protein kinase C显示文摘	Dettwiler S Rommelaere J Nüesch J	1999	J Virol1999，73，9：	1

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